[\/et_pb_text][et_pb_button _builder_version=”3.17.6″ button_text=”Read Alport latest news” button_url=”https:\/\/sites.manchester.ac.uk\/alport-hub\/news-publications-and-blog\/” \/][et_pb_divider _builder_version=”3.17.6″]<\/p>\n
[\/et_pb_divider][et_pb_text admin_label=”Text: Jump links” _builder_version=”3.17.6″]<\/p>\n
On this page:<\/strong><\/p>\n [\/et_pb_text][et_pb_text admin_label=”Spacing only” _builder_version=”3.17.6″]<\/p>\n <\/p>\n [\/et_pb_text][\/et_pb_column][et_pb_column type=”1_5″][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”3.0.48″ background_size=”initial” background_position=”top_left” background_repeat=”repeat”][et_pb_column type=”4_4″][et_pb_image admin_label=”Image: Isolated glomeruli” src=”https:\/\/sites.manchester.ac.uk\/alport-hub\/wp-content\/uploads\/sites\/416\/2023\/03\/Isolated_Gloms.jpg” _builder_version=”3.17.6″]<\/p>\n [\/et_pb_image][\/et_pb_column][\/et_pb_row][et_pb_row custom_padding=”3em||0.5em|” parallax_method_1=”off” _builder_version=”3.0.47″ background_size=”initial” background_position=”top_left” background_repeat=”repeat”][et_pb_column type=”1_5″][\/et_pb_column][et_pb_column type=”3_5″][et_pb_text admin_label=”Spacing only” _builder_version=”3.17.6″]<\/p>\n <\/p>\n [\/et_pb_text][et_pb_text admin_label=”Text: About Alport syndrome” _builder_version=”3.17.6″]<\/p>\n Alport syndrome is a genetic condition affecting the function of the kidneys. It can also cause problems with hearing health and with eyes.<\/p>\n Alport syndrome is caused by variants in the Alport genes, COL4A3, COL4A4 or COL4A5. These variants affect the formation of a type of collagen known as collagen IV-alpha 3,4,5 which is important for the long term function of kidneys, ears and eyes.<\/p>\n [\/et_pb_text][et_pb_button admin_label=”Button: The science behind Alport syndrome” button_url=”\/alport-hub\/about-alport-syndrome\/” button_text=”The science behind Alport syndrome” _builder_version=”3.17.6″]<\/p>\n [\/et_pb_button][et_pb_text admin_label=”Spacing \/ back to top” _builder_version=”3.17.6″]<\/p>\n < Back to top<\/a><\/p>\n <\/p>\n [\/et_pb_text][\/et_pb_column][et_pb_column type=”1_5″][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”3.0.48″ background_size=”initial” background_position=”top_left” background_repeat=”repeat”][et_pb_column type=”4_4″][et_pb_divider _builder_version=”3.17.6″]<\/p>\n [\/et_pb_divider][\/et_pb_column][\/et_pb_row][et_pb_row custom_padding=”3em||0.5em|” parallax_method_1=”off” _builder_version=”3.0.47″ background_size=”initial” background_position=”top_left” background_repeat=”repeat”][et_pb_column type=”1_5″][\/et_pb_column][et_pb_column type=”3_5″][et_pb_text admin_label=”Spacing only” _builder_version=”3.17.6″]<\/p>\n <\/p>\n [\/et_pb_text][et_pb_text admin_label=”Text: Our activities” _builder_version=”3.17.6″]<\/p>\n The Stoneygate and Kidney Research UK Alport Research Hub\u202faims to accelerate the discovery and translation of research findings into improved clinical interventions. The Hub also aims to support and enhance the strong, collaborative Alport network and to raise the profile of Alport research across the world. We want to: <\/span><\/span><\/p>\n Our hub will do this through activities at a physical hub in Manchester, and via a virtual hub focusing on data analysis and sequencing.<\/p>\n [\/et_pb_text][et_pb_text admin_label=”Text: Physical and virtual hubs” _builder_version=”3.17.6″]<\/p>\n The physical Hub is based in the Manchester Cell-Matrix Centre<\/a> at The University of Manchester and is led by Rachel Lennon.\u00a0<\/p>\n It offers:\u00a0<\/p>\n <\/p>\n [\/et_pb_text][et_pb_text admin_label=”Subheading: Systems” _builder_version=”3.17.6″]<\/p>\n [\/et_pb_text][et_pb_text admin_label=”Image: Physical hub” _builder_version=”3.17.6″]<\/p>\n [\/et_pb_text][et_pb_text admin_label=”Text: Systems” _builder_version=”3.17.6″]<\/p>\n These systems allow us to run assays in<\/span> cells and in<\/span> tissues<\/span>, carry out detailed analysis of basement membrane function and test new drugs and gene therapies.<\/span><\/span>\u00a0<\/span><\/p>\n [\/et_pb_text][et_pb_text admin_label=”Text: Virtual hub” _builder_version=”3.17.6″]<\/p>\n The virtual Hub is led by Daniel Gale, Neil Turner and Angela Branson.\u00a0\u00a0<\/p>\n The National Registry of Rare Kidney Disease (RaDaR<\/a>) is an initiative of the UK Kidney Association (UKKA<\/a>). Through the RaDaR database, the Hub is able to analyse clinical and genetic data from individuals with Alport syndrome. One of our Hub priorities is to ensure that the data available in RaDaR for our Alport cohort is as complete and as rich as possible. We are linking in with Hospital sites across the UK to push this agenda for our patients.\u00a0<\/p>\n In association with Genomics England<\/a>, whole genome sequencing will be performed on samples from individuals with Alport syndrome. We will use RaDaR to identify and invite patients and families to participate in this project. Information regarding recruitment events will also be distributed on Alport UK\u2019s social media platforms to ensure that everyone has opportunity to participate in this exciting project.\u00a0<\/p>\n The combined analysis from RaDaR and genomic sequencing will help us to understand how genetic and environmental factors influence Alport syndrome.\u00a0\u00a0<\/p>\n <\/p>\n [\/et_pb_text][et_pb_text admin_label=”Image: Virtual hub” _builder_version=”3.17.6″]<\/p>\n [\/et_pb_text][et_pb_text admin_label=”Text: Virtual hub” _builder_version=”3.17.6″]<\/p>\n Our aim is to help identify those at greatest risk who most need treatment, and to find new targets for treatments that should protect Alport kidneys.<\/p>\n [\/et_pb_text][et_pb_text admin_label=”Spacing \/ back to top” _builder_version=”3.17.6″]<\/p>\n \n< Back to top<\/a><\/p>\n <\/p>\n [\/et_pb_text][\/et_pb_column][et_pb_column type=”1_5″][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”3.0.48″ background_size=”initial” background_position=”top_left” background_repeat=”repeat”][et_pb_column type=”4_4″][et_pb_divider _builder_version=”3.17.6″]<\/p>\n [\/et_pb_divider][\/et_pb_column][\/et_pb_row][et_pb_row custom_padding=”3em||0.5em|” parallax_method_1=”off” _builder_version=”3.0.47″ background_size=”initial” background_position=”top_left” background_repeat=”repeat”][et_pb_column type=”1_5″][\/et_pb_column][et_pb_column type=”3_5″][et_pb_text admin_label=”Spacing only” _builder_version=”3.17.6″]<\/p>\n <\/p>\n [\/et_pb_text][et_pb_text admin_label=”Text:Support our work” _builder_version=”3.17.6″]<\/p>\n If you have an interest in Alport syndrome<\/span> and <\/span>you\u2019re<\/span> a patient, researcher or work in industry<\/span>,<\/span> there are ways you can work with us. <\/span>Find out how<\/span>:<\/span><\/span> <\/span><\/p>\n [\/et_pb_text][et_pb_text admin_label=”Spacing only” _builder_version=”3.17.6″]<\/p>\n <\/p>\n [\/et_pb_text][\/et_pb_column][et_pb_column type=”1_5″][\/et_pb_column][\/et_pb_row][et_pb_row custom_padding=”3em||0.5em|” parallax_method_1=”off” _builder_version=”3.0.47″ background_size=”initial” background_position=”top_left” background_repeat=”repeat”][et_pb_column type=”1_3″][et_pb_cta admin_label=”Content Box Industry” title=”Industry ” button_url=”https:\/\/sites.manchester.ac.uk\/alport-hub\/work-with-us\/industry\/” button_text=”Find out more” module_class=”content_box content_box_dark_bg” _builder_version=”3.17.6″ text_orientation=”left” link_option_url=”https:\/\/sites.manchester.ac.uk\/alport-hub\/work-with-us\/industry\/” use_border_color=”off” border_color=”#ffffff” border_style=”solid” button_letter_spacing_hover=”0″]<\/p>\n Discover industrial collaborations and explore the research hub’s offerings.<\/p>\n [\/et_pb_cta][\/et_pb_column][et_pb_column type=”1_3″][et_pb_cta admin_label=”Content Box Patients” title=”Patients” button_url=”https:\/\/sites.manchester.ac.uk\/alport-hub\/work-with-us\/patients\/” button_text=”Find out more” module_class=”content_box content_box_dark_bg” _builder_version=”3.17.6″ text_orientation=”left” link_option_url=”https:\/\/sites.manchester.ac.uk\/alport-hub\/work-with-us\/patients\/” use_border_color=”off” border_color=”#ffffff” border_style=”solid” button_letter_spacing_hover=”0″]<\/p>\n Learn how to join our research, explore clinical trials, and access support.<\/p>\n [\/et_pb_cta][\/et_pb_column][et_pb_column type=”1_3″][et_pb_cta admin_label=”Content Box Researcher” title=”Researchers” button_url=”https:\/\/sites.manchester.ac.uk\/alport-hub\/work-with-us\/researchers\/” button_text=”Find out more” module_class=”content_box content_box_dark_bg” _builder_version=”3.17.6″ text_orientation=”left” link_option_url=”https:\/\/sites.manchester.ac.uk\/alport-hub\/work-with-us\/researchers\/” use_border_color=”off” border_color=”#ffffff” border_style=”solid” button_letter_spacing_hover=”0″]<\/p>\n Explore hub projects and find out about funding opportunities.<\/p>\n [\/et_pb_cta][\/et_pb_column][\/et_pb_row][et_pb_row custom_padding=”3em||0.5em|” parallax_method_1=”off” _builder_version=”3.0.47″ background_size=”initial” background_position=”top_left” background_repeat=”repeat”][et_pb_column type=”1_5″][\/et_pb_column][et_pb_column type=”3_5″][et_pb_text admin_label=”Spacing only” _builder_version=”3.17.6″]<\/p>\n <\/p>\n [\/et_pb_text][et_pb_text admin_label=”Spacing \/ back to top” _builder_version=”3.17.6″]<\/p>\n < Back to top<\/a><\/p>\n <\/p>\n [\/et_pb_text][\/et_pb_column][et_pb_column type=”1_5″][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”3.0.48″ background_size=”initial” background_position=”top_left” background_repeat=”repeat”][et_pb_column type=”4_4″][et_pb_image admin_label=”Image: Human biopsy” src=”https:\/\/sites.manchester.ac.uk\/alport-hub\/wp-content\/uploads\/sites\/416\/2023\/03\/Human_Biposy_TRPCPdlxn.jpg” _builder_version=”3.17.6″]<\/p>\n [\/et_pb_image][\/et_pb_column][\/et_pb_row][et_pb_row custom_padding=”3em||0.5em|” parallax_method_1=”off” _builder_version=”3.0.47″ background_size=”initial” background_position=”top_left” background_repeat=”repeat”][et_pb_column type=”1_5″][\/et_pb_column][et_pb_column type=”3_5″][et_pb_text admin_label=”Spacing only” _builder_version=”3.17.6″]<\/p>\n <\/p>\n [\/et_pb_text][et_pb_text admin_label=”Text: Our partners” _builder_version=”3.17.6″]<\/p>\n Kidney Research UK is the leading charity in the UK focused on funding research into the prevention, treatment and management of kidney disease. Its vision is the day when everyone lives free from kidney disease. For more than 60 years the research it funds has been making an impact.<\/span>\u00a0<\/span><\/p>\n Kidney Research UK works with clinicians and scientists across the UK. It collaborates with partners across the public, private and third sectors to prevent kidney disease and drive innovation to transform treatments.<\/span>\u00a0<\/span><\/p>\n Over the last ten years the charity has invested more than \u00a358 million into research. It lobbies governments and decision makers to change policy and practice to ensure that more than 7.1 million people living with kidney disease in the UK have access to the most effective care and treatment, and to make kidney disease a priority.<\/span>\u00a0<\/span><\/p>\n Most importantly, the patient voice is at the centre of everything at Kidney Research UK. Patients, carers and families inspire the charity\u2019s mission and push it forward to make a difference and change the future of kidney disease.<\/span>\u00a0<\/span><\/p>\n The Stoneygate Trust funds scientific initiatives across a broad range of medical research fields. The Trust also supports educational initiatives which help bright and enthusiastic students excel.\u00a0<\/span>\u00a0<\/span><\/p>\n Alport UK\u202fis a\u202fpatient-led organisation\u202fdedicated to\u202fempowering individuals and families living with Alport syndrome\u202fto enjoy the best possible quality of life.<\/span>\u00a0<\/span><\/p>\n [\/et_pb_text][et_pb_text admin_label=”Spacing \/ back to top” _builder_version=”3.17.6″]<\/p>\n < Back to top<\/a><\/p>\n <\/p>\n [\/et_pb_text][\/et_pb_column][et_pb_column type=”1_5″][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”3.0.48″ background_size=”initial” background_position=”top_left” background_repeat=”repeat”][et_pb_column type=”4_4″][et_pb_divider _builder_version=”3.17.6″]<\/p>\n [\/et_pb_divider][\/et_pb_column][\/et_pb_row][et_pb_row custom_padding=”3em||0.5em|” parallax_method_1=”off” _builder_version=”3.0.47″ background_size=”initial” background_position=”top_left” background_repeat=”repeat”][et_pb_column type=”1_5″][\/et_pb_column][et_pb_column type=”3_5″][et_pb_text admin_label=”Spacing only” _builder_version=”3.17.6″]<\/p>\n <\/p>\n [\/et_pb_text][et_pb_text admin_label=”Text: Our team” _builder_version=”3.17.6″]<\/p>\n <\/p>\n The Alport Research Hub team comprises colleagues from The University of Manchester, University College London, University of Edinburgh, the University of Nottingham, and the University of Birmingham.<\/p>\n <\/p>\n <\/p>\n <\/p>\n <\/p>\n <\/p>\n <\/p>\n <\/p>\n [\/et_pb_text][et_pb_text admin_label=”Spacing \/ back to top” _builder_version=”3.17.6″]<\/p>\n < Back to top<\/a><\/p>\n <\/p>\n [\/et_pb_text][\/et_pb_column][et_pb_column type=”1_5″][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”3.0.48″ background_size=”initial” background_position=”top_left” background_repeat=”repeat”][et_pb_column type=”4_4″][et_pb_divider _builder_version=”3.17.6″]<\/p>\n [\/et_pb_divider][\/et_pb_column][\/et_pb_row][et_pb_row custom_padding=”3em||0.5em|” parallax_method_1=”off” _builder_version=”3.0.47″ background_size=”initial” background_position=”top_left” background_repeat=”repeat”][et_pb_column type=”1_5″][\/et_pb_column][et_pb_column type=”3_5″][et_pb_text admin_label=”Spacing only” _builder_version=”3.17.6″]<\/p>\n <\/p>\n [\/et_pb_text][et_pb_text admin_label=”Text: News” _builder_version=”3.17.6″]<\/p>\n Read the latest updates on our activities and events on our blog and our original research, reviews and workshop reports.<\/p>\n [\/et_pb_text][et_pb_button button_url=”https:\/\/sites.manchester.ac.uk\/alport-hub\/blog\/” button_text=”Visit the blog” _builder_version=”3.17.6″]<\/p>\n [\/et_pb_button][et_pb_text admin_label=”Backto top” _builder_version=”3.17.6″]<\/p>\n \n< Back to top<\/a><\/p>\n <\/p>\n [\/et_pb_text][\/et_pb_column][et_pb_column type=”1_5″][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”3.0.48″ background_size=”initial” background_position=”top_left” background_repeat=”repeat”][et_pb_column type=”4_4″][et_pb_divider _builder_version=”3.17.6″]<\/p>\n [\/et_pb_divider][\/et_pb_column][\/et_pb_row][et_pb_row custom_padding=”3em||0.5em|” parallax_method_1=”off” _builder_version=”3.0.47″ background_size=”initial” background_position=”top_left” background_repeat=”repeat”][et_pb_column type=”1_5″][\/et_pb_column][et_pb_column type=”3_5″][et_pb_text admin_label=”Spacing only” _builder_version=”3.17.6″]<\/p>\n <\/p>\n [\/et_pb_text][et_pb_text admin_label=”Text: Publications title and intro” _builder_version=”3.17.6″]<\/p>\n Recent top ten publications showcasing key research discoveries and developments.<\/p>\n [\/et_pb_text][et_pb_text admin_label=”Top ten publications” _builder_version=”3.17.6″]<\/p>\n <\/p>\n [\/et_pb_text][et_pb_button _builder_version=”3.17.6″ button_text=”Read more publications” button_url=”https:\/\/sites.manchester.ac.uk\/alport-hub\/publications\/” \/][et_pb_text admin_label=”Backto top” _builder_version=”3.17.6″]<\/p>\n \n< Back to top<\/a><\/p>\n <\/p>\n [\/et_pb_text][\/et_pb_column][et_pb_column type=”1_5″][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”3.0.48″ background_size=”initial” background_position=”top_left” background_repeat=”repeat”][et_pb_column type=”4_4″][et_pb_divider _builder_version=”3.17.6″]<\/p>\n [\/et_pb_divider][\/et_pb_column][\/et_pb_row][et_pb_row custom_padding=”3em||0.5em|” parallax_method_1=”off” _builder_version=”3.0.47″ background_size=”initial” background_position=”top_left” background_repeat=”repeat”][et_pb_column type=”1_5″][\/et_pb_column][et_pb_column type=”3_5″][et_pb_text admin_label=”Spacing only” _builder_version=”3.17.6″]<\/p>\n <\/p>\n [\/et_pb_text][et_pb_text admin_label=”Text: Contact us” _builder_version=”3.17.6″]<\/p>\n If you have any queries about the Alport Research Hub and our activities, please get in touch.<\/p>\n Rachel Lennon<\/span><\/b> (University of Manchester)<\/span>\u00a0 Daniel Gale <\/span><\/b>(University College London)<\/span>\u00a0 Neil Turner<\/span><\/b> (University of Edinburgh)<\/span>\u00a0 [\/et_pb_text][et_pb_text admin_label=”Spacing \/ back to top” _builder_version=”3.17.6″]<\/p>\n\n
About Alport syndrome<\/h2>\n
What is the Stoneygate and Kidney Research UK Alport Research Hub?<\/span><\/span><\/h2>\n
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Physical hub<\/h3>\n
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Systems used to investigate Alport syndrome<\/h4>\n
![\"This](\"https:\/\/sites.manchester.ac.uk\/alport-hub\/wp-content\/uploads\/sites\/416\/2023\/03\/Physical_Hub_Figure_4.png\")
<\/p>\nVirtual hub<\/h3>\n
![\"Diagram](\"https:\/\/sites.manchester.ac.uk\/alport-hub\/wp-content\/uploads\/sites\/416\/2023\/04\/Image_6_Copy_of_Alport_Virtual_Hub_Figure_2.png\")
<\/p>\nWork with us<\/h2>\n
Our partners<\/h2>\n
Kidney Research UK<\/span>\u00a0<\/span><\/h3>\n
Stoneygate Trust<\/span>\u00a0<\/span><\/h3>\n
Alport UK<\/span>\u00a0<\/span><\/h3>\n
Our team<\/h2>\n
Physical hub<\/h3>\n
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Virtual hub<\/h3>\n
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Hub Collaborators<\/h3>\n
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News<\/h2>\n
Publications<\/h2>\n
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Contact us<\/h2>\n
Email: <\/span>rachel.lennon@manchester.ac.uk<\/span><\/a>\u00a0<\/span>\u00a0<\/span><\/p>\n
Email: <\/span>d.gale@ucl.ac.uk<\/span><\/a>\u00a0<\/span>\u00a0<\/span><\/p>\n
Email: <\/span>neil.turner@ed.ac.uk<\/span><\/a>\u00a0<\/span>\u00a0<\/span><\/p>\n
![\"Alport](\"https:\/\/sites.manchester.ac.uk\/alport-hub\/wp-content\/uploads\/sites\/416\/2023\/04\/Image_1_Alport_Research_Hub_Stacked.jpg\")
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<\/p>\n![\"UCL](\"https:\/\/sites.manchester.ac.uk\/alport-hub\/wp-content\/uploads\/sites\/416\/2023\/03\/logo-Dept_Renal_Medicine_UCL.png\"){kind=logo}
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