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[et_pb_section bb_built=”1″ admin_label=”section” fullwidth=”on” next_background_color=”#000000″ global_module=”322″][et_pb_fullwidth_menu global_parent=”322″ _builder_version=”3.0.106″ menu_id=”7″ submenu_direction=”downwards” fullwidth_menu=”off” background_layout=”dark” module_class=”main-navigation” \/][\/et_pb_section][et_pb_section bb_built=”1″ fullwidth=”on” specialty=”off” prev_background_color=”#000000″ next_background_color=”#000000″][et_pb_fullwidth_slider show_arrows=”off” show_pagination=”off” background_position=”top_left” custom_css_slide_description=”animation: none!important;” custom_css_slide_title=”animation:none!important;” custom_padding=”|||” box_shadow_blur=”10px” box_shadow_color=”rgba(0,0,0,0.1)” button_text_size__hover_enabled=”off” button_text_size__hover=”null” button_one_text_size__hover_enabled=”off” button_one_text_size__hover=”null” button_two_text_size__hover_enabled=”off” button_two_text_size__hover=”null” button_text_color__hover_enabled=”off” button_text_color__hover=”null” button_one_text_color__hover_enabled=”off” button_one_text_color__hover=”null” button_two_text_color__hover_enabled=”off” button_two_text_color__hover=”null” button_border_width__hover_enabled=”off” button_border_width__hover=”null” button_one_border_width__hover_enabled=”off” button_one_border_width__hover=”null” button_two_border_width__hover_enabled=”off” button_two_border_width__hover=”null” button_border_color__hover_enabled=”off” button_border_color__hover=”null” button_one_border_color__hover_enabled=”off” button_one_border_color__hover=”null” button_two_border_color__hover_enabled=”off” button_two_border_color__hover=”null” button_border_radius__hover_enabled=”off” button_border_radius__hover=”null” button_one_border_radius__hover_enabled=”off” button_one_border_radius__hover=”null” button_two_border_radius__hover_enabled=”off” button_two_border_radius__hover=”null” button_letter_spacing__hover_enabled=”on” button_letter_spacing__hover=”0″ button_one_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover=”null” button_two_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover=”null” button_bg_color__hover_enabled=”off” button_bg_color__hover=”null” button_one_bg_color__hover_enabled=”off” button_one_bg_color__hover=”null” button_two_bg_color__hover_enabled=”off” button_two_bg_color__hover=”null” _builder_version=”3.17.6″][et_pb_slide _builder_version=”3.17.6″ heading=”Centre for Biological Timing” button_link=”#” url_new_window=”off” link_option_url_new_window=”off” background_color=”#ffffff” use_background_color_gradient=”off” background_color_gradient_start=”#2b87da” background_color_gradient_end=”#29c4a9″ background_color_gradient_type=”linear” background_color_gradient_direction=”180deg” background_color_gradient_direction_radial=”center” background_color_gradient_start_position=”0%” background_color_gradient_end_position=”100%” background_color_gradient_overlays_image=”off” background_image=”https:\/\/sites.manchester.ac.uk\/bio-timing\/wp-content\/uploads\/sites\/348\/2024\/10\/dna-wave.jpg” parallax=”off” parallax_method=”on” background_size=”cover” background_position=”top_left” background_repeat=”no-repeat” background_blend=”normal” allow_player_pause=”off” background_video_pause_outside_viewport=”on” use_bg_overlay=”off” use_text_overlay=”off” text_border_radius=”3″ alignment=”center” child_filter_hue_rotate=”0deg” child_filter_saturate=”100%” child_filter_brightness=”100%” child_filter_contrast=”100%” child_filter_invert=”0%” child_filter_sepia=”0%” child_filter_opacity=”100%” child_filter_blur=”0px” child_mix_blend_mode=”normal” background_layout=”dark” text_shadow_style=”none” header_text_shadow_style=”none” body_text_shadow_style=”none” custom_button=”on” button_bg_color=”#27a2db” button_bg_use_color_gradient=”off” button_bg_color_gradient_overlays_image=”off” button_border_color=”#27a2db” button_use_icon=”on” button_on_hover=”on” button_text_shadow_style=”none” box_shadow_style_button=”none” hover_transition_duration=”300ms” hover_transition_delay=”0ms” hover_transition_speed_curve=”ease” text_shadow_horizontal_length=”0em” text_shadow_vertical_length=”0em” text_shadow_blur_strength=”0em” header_text_shadow_horizontal_length=”0em” header_text_shadow_vertical_length=”0em” header_text_shadow_blur_strength=”0em” body_text_shadow_horizontal_length=”0em” body_text_shadow_vertical_length=”0em” body_text_shadow_blur_strength=”0em” button_text_shadow_horizontal_length=”0em” button_text_shadow_vertical_length=”0em” button_text_shadow_blur_strength=”0em”]<\/p>\n

Understanding the rhythms of life.<\/p>\n

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The University of Manchester is home to the largest biological timing research community in Europe. Led by Professor Robert Lucas, we bring together world-leading researchers with a multidisciplinary approach to cellular timers and circadian clocks.<\/p>\n

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\nBiological timing is a central feature of all living things. Driven by endogenous biological clocks, the ability to track time allows organisms to adapt their biology and optimally respond to the fluctuating environment of our planet.<\/p>\n

Critical to this is the role of internal timers in coordinating innumerable cellular and physiological processes, which drive our development and biology, from gene expression to behaviour.<\/p>\n

Our research<\/h2>\n

Our research ranges from nocturnal and diurnal model organisms and understanding of fundamental molecular and cellular events, to clinical intervention into human diseases, including diabetes and inflammatory arthritis.<\/p>\n

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On this page:<\/p>\n

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  1. Research themes<\/a><\/li>\n
  2. Our researchers<\/a><\/li>\n
  3. Postgraduates and early career researchers<\/a><\/li>\n
  4. Publications<\/a><\/li>\n
  5. Contact us<\/a><\/li>\n<\/ol>\n

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    [\/et_pb_text][et_pb_text admin_label=”Title: Our research” _builder_version=”3.17.6″]<\/p>\n

    Research themes<\/h2>\n

    [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row][et_pb_column type=”1_2″][et_pb_text admin_label=”Text: Internal homeostasis and clock mechanisms” _builder_version=”3.17.6″]<\/p>\n

    Internal homeostasis and clock mechanisms<\/h3>\n

    Disturbance of circadian rhythms impacts negatively on our health and wellbeing. This recognition provides opportunity \u2013 by understanding how the circadian clock regulates our physiology, drives disease, and the outlook for using the clock to advance new therapies?<\/p>\n

    Keywords:<\/strong> Metabolism, cardiovascular physiology, immunology, methylation, tissue homeostasis, mathematical modelling.<\/p>\n

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    \"Homeostasis<\/p>\n

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    Clinical translation and multi-morbidity<\/h3>\n

    Driving research in clock genes forward to address the gap in biomedical research and clinical practice.<\/p>\n

    Keywords:<\/strong>\u00a0Fibrosis, asthma, inflammation, sleep.<\/p>\n

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    \"Researcher<\/p>\n

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    Brain, behaviour and environmental response<\/h3>\n

    The ability to respond to rhythmic fluctuations in the environment caused by the earth\u2019s rotation (such as light, colour, temperature, food availability) is critical for survival for most organisms on the planet. But how do we perceive these diverse temporal pat terns and then translate them into a rhythmic biology?<\/p>\n

    Keywords:<\/strong>\u00a0Physiological responses to light, seasonal rhythms, optogenetics.<\/p>\n

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    Our researchers<\/h2>\n

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    Find out more about how some of our researchers contribute to research in biological timing.<\/p>\n

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    \nYou can view a list of our researchers who work in each of our research areas.<\/p>\n

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    John Blaikley<\/strong><\/p>\n

    Rhythms in fibrosis.<\/p>\n