{"id":3584,"date":"2022-12-05T10:13:01","date_gmt":"2022-12-05T10:13:01","guid":{"rendered":"https:\/\/sites.manchester.ac.uk\/covid19-national-project\/?p=3584"},"modified":"2026-07-14T14:57:50","modified_gmt":"2026-07-14T13:57:50","slug":"omicron-breakthrough-infections-in-previously-infected-or-vaccinated-hamsters","status":"publish","type":"post","link":"https:\/\/sites.manchester.ac.uk\/covid19-national-project\/2022\/12\/05\/omicron-breakthrough-infections-in-previously-infected-or-vaccinated-hamsters\/","title":{"rendered":"Omicron breakthrough infections in previously infected or vaccinated hamsters"},"content":{"rendered":"<p>[et_pb_section bb_built=&#8221;1&#8243; fullwidth=&#8221;off&#8221; specialty=&#8221;on&#8221; next_background_color=&#8221;#000000&#8243;][et_pb_column type=&#8221;2_3&#8243; specialty_columns=&#8221;2&#8243;][et_pb_row_inner locked=&#8221;off&#8221;][et_pb_column_inner type=&#8221;4_4&#8243; saved_specialty_column_type=&#8221;2_3&#8243;][et_pb_post_title _builder_version=&#8221;3.0.106&#8243; title=&#8221;on&#8221; meta=&#8221;on&#8221; author=&#8221;on&#8221; date=&#8221;on&#8221; categories=&#8221;on&#8221; comments=&#8221;on&#8221; featured_image=&#8221;on&#8221; featured_placement=&#8221;above&#8221; text_color=&#8221;dark&#8221; text_background=&#8221;off&#8221; locked=&#8221;on&#8221; parent_locked=&#8221;off&#8221; \/][et_pb_text _builder_version=&#8221;3.17.6&#8243; background_layout=&#8221;light&#8221; parent_locked=&#8221;off&#8221;]<\/p>\n<p>The second and third years of the SARS-CoV-2 pandemic have been marked by the repeated emergence and replacement of \u2018variants\u2019, the most recent examples being Delta and Omicron.<\/p>\n<p>Researchers from <span style=\"text-decoration: underline\"><a href=\"https:\/\/sites.manchester.ac.uk\/covid19-national-project\/research-themes\/experimental-infections-of-human-and-animals-to-characterise-sars-cov2-transmission\/\">theme 5 of the PROTECT NCS<\/a><\/span>\u00a0presented their work at this year&#8217;s Options conference in Belfast,\u00a0which is the only global scientific meeting with a dedicated focus on influenza. Their poster describes a hamster contact exposure challenge model to assess protection conferred by vaccination or prior infection against re-infection.<\/p>\n<p><strong>Content warning: This poster contains an image of a live hamster during an experiment.<\/strong><\/p>\n<p>[\/et_pb_text][et_pb_button admin_label=&#8221;Button: Download the poster&#8221; button_text=&#8221;Download the poster&#8221; _builder_version=&#8221;3.17.6&#8243; button_url=&#8221;https:\/\/documents.manchester.ac.uk\/display.aspx?DocID=64824&#8243; \/][et_pb_text _builder_version=&#8221;3.17.6&#8243; background_layout=&#8221;light&#8221; parent_locked=&#8221;off&#8221;]<\/p>\n<p>Imperial College aims to be open about research involving animals. Animal research is strictly regulated by the <a href=\"https:\/\/www.gov.uk\/guidance\/research-and-testing-using-animals\"><span style=\"text-decoration: underline\">Home Office<\/span><\/a> and overseen at Imperial College by several <a href=\"https:\/\/www.imperial.ac.uk\/research-ethics-committee\/committees\/\"><span style=\"text-decoration: underline\">ethical committees<\/span><\/a>.<\/p>\n<p>Find out <span style=\"text-decoration: underline\"><a href=\"https:\/\/www.imperial.ac.uk\/research-and-innovation\/about-imperial-research\/research-integrity-investigations\/animal-research\/\">more about animal research at Imperial<\/a><\/span>.<\/p>\n<p>[\/et_pb_text][et_pb_post_nav _builder_version=&#8221;3.0.106&#8243; in_same_term=&#8221;off&#8221; show_prev=&#8221;on&#8221; show_next=&#8221;on&#8221; prev_text=&#8221;Previous&#8221; next_text=&#8221;Next&#8221; locked=&#8221;on&#8221; parent_locked=&#8221;off&#8221; \/][et_pb_comments _builder_version=&#8221;3.0.106&#8243; show_avatar=&#8221;on&#8221; 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button_border_width__hover=&#8221;null&#8221; button_one_border_width__hover_enabled=&#8221;off&#8221; button_one_border_width__hover=&#8221;null&#8221; button_two_border_width__hover_enabled=&#8221;off&#8221; button_two_border_width__hover=&#8221;null&#8221; button_border_color__hover_enabled=&#8221;off&#8221; button_border_color__hover=&#8221;null&#8221; button_one_border_color__hover_enabled=&#8221;off&#8221; button_one_border_color__hover=&#8221;null&#8221; button_two_border_color__hover_enabled=&#8221;off&#8221; button_two_border_color__hover=&#8221;null&#8221; button_border_radius__hover_enabled=&#8221;off&#8221; button_border_radius__hover=&#8221;null&#8221; button_one_border_radius__hover_enabled=&#8221;off&#8221; button_one_border_radius__hover=&#8221;null&#8221; button_two_border_radius__hover_enabled=&#8221;off&#8221; button_two_border_radius__hover=&#8221;null&#8221; button_letter_spacing__hover_enabled=&#8221;off&#8221; button_letter_spacing__hover=&#8221;null&#8221; button_one_letter_spacing__hover_enabled=&#8221;off&#8221; 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saved_specialty_column_type=&#8221;2_3&#8243;][et_pb_post_title _builder_version=&#8221;3.0.106&#8243; title=&#8221;on&#8221; meta=&#8221;on&#8221; author=&#8221;on&#8221; date=&#8221;on&#8221; categories=&#8221;on&#8221; comments=&#8221;on&#8221; featured_image=&#8221;on&#8221; featured_placement=&#8221;above&#8221; text_color=&#8221;dark&#8221; text_background=&#8221;off&#8221; locked=&#8221;on&#8221; parent_locked=&#8221;off&#8221; \/][et_pb_text _builder_version=&#8221;3.17.6&#8243; background_layout=&#8221;light&#8221; parent_locked=&#8221;off&#8221;]<\/p>\n<p class=\"paragraph ng-attr-widget\"><span class=\"ng-directive ng-binding\">Fruitcake cake danish oat cake powder jujubes caramels chupa chups jelly beans. Bonbon tootsie roll jelly souffl\u00e9 fruitcake tootsie roll jelly sesame snaps cake. Gingerbread cotton candy oat cake jelly-o candy apple pie powder. Marshmallow powder chocolate bar sugar plum chocolate bar wafer marshmallow sugar plum bear claw. Marzipan macaroon bonbon sweet powder chocolate cake donut toffee carrot cake. Ice cream apple pie pastry. Wafer biscuit brownie bonbon. Pudding muffin tiramisu powder biscuit souffl\u00e9 biscuit chupa chups chupa chups. Powder lemon drops pastry apple pie lemon drops cotton candy. Pudding macaroon halvah jelly brownie drag\u00e9e sweet roll caramels jelly beans. Cookie biscuit lollipop. Donut jelly beans wafer marzipan powder oat cake gummies icing chocolate bar. Dessert fruitcake donut cupcake. Jelly macaroon brownie gingerbread cupcake donut fruitcake.<\/span><\/p>\n<p class=\"paragraph ng-attr-widget\"><span class=\"ng-directive ng-binding\">Sweet lemon drops topping brownie lollipop gummies biscuit candy canes donut. Jelly-o fruitcake macaroon. Muffin topping pudding liquorice danish chupa chups carrot cake cake. Sugar plum chupa chups apple pie chocolate cake bear claw chupa chups brownie topping carrot cake. Pastry gummi bears chocolate cake. Cake chocolate bar sugar plum icing cotton candy. Chupa chups halvah jelly macaroon candy canes danish halvah bonbon. Pie chupa chups sweet roll drag\u00e9e pie wafer pudding. Souffl\u00e9 jujubes jelly liquorice pudding pastry cotton candy pastry. Chupa chups jelly beans carrot cake caramels ice cream fruitcake. Candy gingerbread powder sugar plum macaroon candy oat cake tiramisu. Souffl\u00e9 drag\u00e9e sesame snaps powder topping halvah. Croissant gummies dessert donut drag\u00e9e biscuit toffee. 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global_module=&#8221;1519&#8243;][et_pb_row admin_label=&#8221;row&#8221; global_parent=&#8221;1519&#8243; parallax_method_1=&#8221;off&#8221; parallax_method_2=&#8221;off&#8221; parallax_method_3=&#8221;off&#8221; module_id=&#8221;footer-row&#8221; _builder_version=&#8221;3.0.89&#8243;][et_pb_column type=&#8221;1_3&#8243;][et_pb_text admin_label=&#8221;Address Title&#8221; global_parent=&#8221;1519&#8243; _builder_version=&#8221;3.17.6&#8243; text_text_color=&#8221;#ffffff&#8221; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; background_layout=&#8221;dark&#8221;]<\/p>\n<p style=\"color: #fff !important;font-size: 1.3em;font-weight: 600\">Contact Us<\/p>\n<p>[\/et_pb_text][et_pb_text admin_label=&#8221;Address&#8221; global_parent=&#8221;1519&#8243; module_id=&#8221;address&#8221; module_class=&#8221;contact-us&#8221; _builder_version=&#8221;3.17.6&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; background_layout=&#8221;dark&#8221; use_border_color=&#8221;off&#8221; border_color=&#8221;#ffffff&#8221; border_style=&#8221;solid&#8221;]<\/p>\n<p>Email:\u00a0<span style=\"text-decoration: underline\"><a href=\"mailto:PROTECT@hse.gov.uk\" target=\"_blank\" rel=\"noopener noreferrer\">PROTECT@hse.gov.uk<\/a><\/span><\/p>\n<p>Health &amp; Safety Executive \u2013 Science Division<br \/>Harpur Hill<br \/>Buxton<br \/>SK17 9JN<\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_3&#8243;][et_pb_text admin_label=&#8221;Connect Title&#8221; global_parent=&#8221;1519&#8243; _builder_version=&#8221;3.17.6&#8243; text_text_color=&#8221;#ffffff&#8221; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; background_layout=&#8221;dark&#8221;]<\/p>\n<p style=\"color: #fff !important;font-size: 1.3em;font-weight: 600\">Connect with us<\/p>\n<p>[\/et_pb_text][et_pb_code admin_label=&#8221;Social Media&#8221; global_parent=&#8221;1519&#8243; _builder_version=&#8221;3.17.6&#8243;]<\/p>\n<ul class=\"inlineList footer-socialIcons\"><!-- [et_pb_line_break_holder] --><\/p>\n<li><!-- [et_pb_line_break_holder] --> <a href=\"https:\/\/twitter.com\/PROTECT_NCS\"><!-- [et_pb_line_break_holder] --> <img loading=\"lazy\" decoding=\"async\" class=\"lazy\" src=\"\/\/assets.manchester.ac.uk\/phase1\/templates\/images\/icon-twitter-50.png\" alt=\"Twitter page for the PROTECT National Core Study.\" width=\"40\" height=\"40\" \/><!-- [et_pb_line_break_holder] --> <\/a><!-- [et_pb_line_break_holder] --><\/li>\n<p><!-- [et_pb_line_break_holder] --><\/p>\n<li><!-- [et_pb_line_break_holder] --> <a href=\"https:\/\/www.youtube.com\/channel\/UCU8kCv9oZAJCNrP3KZmRgTQ\"><!-- [et_pb_line_break_holder] --> <img loading=\"lazy\" decoding=\"async\" class=\"lazy\" src=\"\/\/assets.manchester.ac.uk\/phase1\/templates\/images\/icon-youtube-50.png\" alt=\"YouTube channel for the PROTECT project.\" width=\"40\" height=\"40\" \/><!-- [et_pb_line_break_holder] --> <\/a><!-- [et_pb_line_break_holder] --><\/li>\n<p><!-- [et_pb_line_break_holder] --><\/ul>\n<p>[\/et_pb_code][\/et_pb_column][et_pb_column type=&#8221;1_3&#8243;][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The second and third years of the SARS-CoV-2 pandemic have been marked by the repeated emergence and replacement of \u2018variants\u2019, the most recent examples being Delta and Omicron.Researchers from theme 5 of the PROTECT NCS\u00a0presented their work at this year&#8217;s Options conference in Belfast,\u00a0which is the only global scientific meeting with a dedicated focus on [&hellip;]<\/p>\n","protected":false},"author":4299,"featured_media":2354,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"<p>[et_pb_section bb_built=\"1\" admin_label=\"section\" fullwidth=\"on\" next_background_color=\"#000000\" global_module=\"322\"][et_pb_fullwidth_menu global_parent=\"322\" _builder_version=\"3.0.106\" menu_id=\"7\" submenu_direction=\"downwards\" fullwidth_menu=\"off\" background_layout=\"dark\" module_class=\"main-navigation\" \/][\/et_pb_section][et_pb_section bb_built=\"1\" fullwidth=\"off\" specialty=\"on\" prev_background_color=\"#000000\" next_background_color=\"#1d1d1d\"][et_pb_column type=\"2_3\" specialty_columns=\"2\"][et_pb_row_inner locked=\"off\"][et_pb_column_inner type=\"4_4\" saved_specialty_column_type=\"2_3\"][et_pb_post_title _builder_version=\"3.0.106\" title=\"on\" meta=\"on\" author=\"on\" date=\"on\" categories=\"on\" comments=\"on\" featured_image=\"on\" featured_placement=\"above\" text_color=\"dark\" text_background=\"off\" locked=\"on\" parent_locked=\"off\" \/][et_pb_text _builder_version=\"3.17.6\" background_layout=\"light\" parent_locked=\"off\"]<\/p><p class=\"paragraph ng-attr-widget\"><span class=\"ng-directive ng-binding\">Fruitcake cake danish oat cake powder jujubes caramels chupa chups jelly beans. 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Donut ice cream lollipop.<\/span><\/p><p>[\/et_pb_text][et_pb_post_nav _builder_version=\"3.0.106\" in_same_term=\"off\" show_prev=\"on\" show_next=\"on\" prev_text=\"Previous\" next_text=\"Next\" locked=\"on\" parent_locked=\"off\" \/][et_pb_comments _builder_version=\"3.0.106\" show_avatar=\"on\" show_reply=\"on\" show_count=\"on\" background_layout=\"light\" header_font_size_tablet=\"51\" header_line_height_tablet=\"2\" custom_button=\"on\" button_icon_placement=\"right\" button_text_color=\"#ffffff\" button_use_icon=\"off\" locked=\"on\" parent_locked=\"off\" button_text_size__hover_enabled=\"off\" button_text_size__hover=\"null\" button_one_text_size__hover_enabled=\"off\" button_one_text_size__hover=\"null\" button_two_text_size__hover_enabled=\"off\" button_two_text_size__hover=\"null\" button_text_color__hover_enabled=\"off\" button_text_color__hover=\"null\" button_one_text_color__hover_enabled=\"off\" button_one_text_color__hover=\"null\" button_two_text_color__hover_enabled=\"off\" button_two_text_color__hover=\"null\" button_border_width__hover_enabled=\"off\" button_border_width__hover=\"null\" button_one_border_width__hover_enabled=\"off\" button_one_border_width__hover=\"null\" button_two_border_width__hover_enabled=\"off\" button_two_border_width__hover=\"null\" button_border_color__hover_enabled=\"off\" button_border_color__hover=\"null\" button_one_border_color__hover_enabled=\"off\" button_one_border_color__hover=\"null\" button_two_border_color__hover_enabled=\"off\" button_two_border_color__hover=\"null\" button_border_radius__hover_enabled=\"off\" button_border_radius__hover=\"null\" button_one_border_radius__hover_enabled=\"off\" button_one_border_radius__hover=\"null\" button_two_border_radius__hover_enabled=\"off\" button_two_border_radius__hover=\"null\" button_letter_spacing__hover_enabled=\"off\" button_letter_spacing__hover=\"null\" button_one_letter_spacing__hover_enabled=\"off\" button_one_letter_spacing__hover=\"null\" button_two_letter_spacing__hover_enabled=\"off\" button_two_letter_spacing__hover=\"null\" button_bg_color__hover_enabled=\"off\" button_bg_color__hover=\"null\" button_one_bg_color__hover_enabled=\"off\" button_one_bg_color__hover=\"null\" button_two_bg_color__hover_enabled=\"off\" button_two_bg_color__hover=\"null\" \/][et_pb_text admin_label=\"Related posts\" _builder_version=\"3.0.106\" background_layout=\"light\" locked=\"on\" parent_locked=\"off\"]<\/p><h1>Related<\/h1><p>[related-posts-thumbnails] [\/et_pb_text][\/et_pb_column_inner][\/et_pb_row_inner][\/et_pb_column][et_pb_column type=\"1_3\"][et_pb_sidebar _builder_version=\"3.0.106\" area=\"sidebar-1\" orientation=\"left\" show_border=\"off\" background_layout=\"light\" locked=\"on\" \/][\/et_pb_column][\/et_pb_section][et_pb_section bb_built=\"1\" _builder_version=\"3.11.1\" background_color=\"#1d1d1d\" prev_background_color=\"#ffffff\" global_module=\"1519\"][et_pb_row admin_label=\"row\" global_parent=\"1519\" parallax_method_1=\"off\" parallax_method_2=\"off\" parallax_method_3=\"off\" module_id=\"footer-row\" _builder_version=\"3.0.89\"][et_pb_column type=\"1_3\"][et_pb_text admin_label=\"Address Title\" global_parent=\"1519\" _builder_version=\"3.17.6\" text_text_color=\"#ffffff\" background_size=\"initial\" background_position=\"top_left\" background_repeat=\"repeat\" background_layout=\"dark\"]<\/p><p style=\"color: #fff !important; font-size: 1.3em; font-weight: 600;\">Contact Us<\/p><p>[\/et_pb_text][et_pb_text admin_label=\"Address\" global_parent=\"1519\" module_id=\"address\" module_class=\"contact-us\" _builder_version=\"3.17.6\" background_size=\"initial\" background_position=\"top_left\" background_repeat=\"repeat\" background_layout=\"dark\" use_border_color=\"off\" border_color=\"#ffffff\" border_style=\"solid\"]<\/p><p>Email:\u00a0<span style=\"text-decoration: underline;\"><a href=\"mailto:PROTECT@hse.gov.uk\" target=\"_blank\" rel=\"noopener noreferrer\">PROTECT@hse.gov.uk<\/a><\/span><\/p><p>Health & Safety Executive \u2013 Science Division<br \/>Harpur Hill<br \/>Buxton<br \/>SK17 9JN<\/p><p>[\/et_pb_text][\/et_pb_column][et_pb_column type=\"1_3\"][et_pb_text admin_label=\"Connect Title\" global_parent=\"1519\" _builder_version=\"3.17.6\" text_text_color=\"#ffffff\" background_size=\"initial\" background_position=\"top_left\" background_repeat=\"repeat\" background_layout=\"dark\"]<\/p><p style=\"color: #fff !important; font-size: 1.3em; font-weight: 600;\">Connect with us<\/p><p>[\/et_pb_text][et_pb_code admin_label=\"Social Media\" global_parent=\"1519\" _builder_version=\"3.17.6\"]<\/p><ul class=\"inlineList footer-socialIcons\"><!-- [et_pb_line_break_holder] --><li><!-- [et_pb_line_break_holder] --> <a href=\"https:\/\/twitter.com\/PROTECT_NCS\"><!-- [et_pb_line_break_holder] --> <img class=\"lazy\" src=\"\/\/assets.manchester.ac.uk\/phase1\/templates\/images\/icon-twitter-50.png\" alt=\"Twitter page for the PROTECT National Core Study.\" width=\"40\" height=\"40\" \/><!-- [et_pb_line_break_holder] --> <\/a><!-- [et_pb_line_break_holder] --><\/li><!-- [et_pb_line_break_holder] --><li><!-- [et_pb_line_break_holder] --> <a href=\"https:\/\/www.youtube.com\/channel\/UCU8kCv9oZAJCNrP3KZmRgTQ\"><!-- [et_pb_line_break_holder] --> <img class=\"lazy\" src=\"\/\/assets.manchester.ac.uk\/phase1\/templates\/images\/icon-youtube-50.png\" alt=\"YouTube channel for the PROTECT project.\" width=\"40\" height=\"40\" \/><!-- [et_pb_line_break_holder] --> <\/a><!-- [et_pb_line_break_holder] --><\/li><!-- [et_pb_line_break_holder] --><\/ul><p>[\/et_pb_code][\/et_pb_column][et_pb_column type=\"1_3\"][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>","_et_gb_content_width":"","_exactmetrics_skip_tracking":false,"footnotes":""},"categories":[65],"tags":[33,115,45,29],"class_list":["post-3584","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-theme-5-experimental-infection","tag-covid-19","tag-experimental-infection","tag-infection","tag-protect"],"_links":{"self":[{"href":"https:\/\/sites.manchester.ac.uk\/covid19-national-project\/wp-json\/wp\/v2\/posts\/3584","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.manchester.ac.uk\/covid19-national-project\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sites.manchester.ac.uk\/covid19-national-project\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/sites.manchester.ac.uk\/covid19-national-project\/wp-json\/wp\/v2\/users\/4299"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.manchester.ac.uk\/covid19-national-project\/wp-json\/wp\/v2\/comments?post=3584"}],"version-history":[{"count":16,"href":"https:\/\/sites.manchester.ac.uk\/covid19-national-project\/wp-json\/wp\/v2\/posts\/3584\/revisions"}],"predecessor-version":[{"id":3599,"href":"https:\/\/sites.manchester.ac.uk\/covid19-national-project\/wp-json\/wp\/v2\/posts\/3584\/revisions\/3599"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/sites.manchester.ac.uk\/covid19-national-project\/wp-json\/wp\/v2\/media\/2354"}],"wp:attachment":[{"href":"https:\/\/sites.manchester.ac.uk\/covid19-national-project\/wp-json\/wp\/v2\/media?parent=3584"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sites.manchester.ac.uk\/covid19-national-project\/wp-json\/wp\/v2\/categories?post=3584"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sites.manchester.ac.uk\/covid19-national-project\/wp-json\/wp\/v2\/tags?post=3584"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}