{"id":1423,"date":"2021-10-28T14:32:32","date_gmt":"2021-10-28T13:32:32","guid":{"rendered":"https:\/\/sites.manchester.ac.uk\/digen\/?page_id=1423"},"modified":"2022-02-14T09:50:31","modified_gmt":"2022-02-14T09:50:31","slug":"home","status":"publish","type":"page","link":"https:\/\/sites.manchester.ac.uk\/digen\/","title":{"rendered":"Home"},"content":{"rendered":"

[et_pb_section bb_built=”1″ admin_label=”section” fullwidth=”on” next_background_color=”#000000″ global_module=”322″][et_pb_fullwidth_menu global_parent=”322″ _builder_version=”3.0.106″ menu_id=”7″ submenu_direction=”downwards” fullwidth_menu=”off” background_layout=”dark” module_class=”main-navigation” \/][\/et_pb_section][et_pb_section bb_built=”1″ fullwidth=”on” specialty=”off” prev_background_color=”#000000″ next_background_color=”#000000″][et_pb_fullwidth_slider show_arrows=”off” show_pagination=”off” background_position=”top_left” custom_css_slide_description=”animation: none!important;” custom_css_slide_title=”animation:none!important;” custom_padding=”|||” box_shadow_blur=”10px” box_shadow_color=”rgba(0,0,0,0.1)” button_text_size__hover_enabled=”off” button_text_size__hover=”null” button_one_text_size__hover_enabled=”off” button_one_text_size__hover=”null” button_two_text_size__hover_enabled=”off” button_two_text_size__hover=”null” button_text_color__hover_enabled=”off” button_text_color__hover=”null” button_one_text_color__hover_enabled=”off” button_one_text_color__hover=”null” button_two_text_color__hover_enabled=”off” button_two_text_color__hover=”null” button_border_width__hover_enabled=”off” button_border_width__hover=”null” button_one_border_width__hover_enabled=”off” button_one_border_width__hover=”null” button_two_border_width__hover_enabled=”off” button_two_border_width__hover=”null” button_border_color__hover_enabled=”off” button_border_color__hover=”null” button_one_border_color__hover_enabled=”off” button_one_border_color__hover=”null” button_two_border_color__hover_enabled=”off” button_two_border_color__hover=”null” button_border_radius__hover_enabled=”off” button_border_radius__hover=”null” button_one_border_radius__hover_enabled=”off” button_one_border_radius__hover=”null” button_two_border_radius__hover_enabled=”off” button_two_border_radius__hover=”null” button_letter_spacing__hover_enabled=”on” button_letter_spacing__hover=”0″ button_one_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover=”null” button_two_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover=”null” button_bg_color__hover_enabled=”off” button_bg_color__hover=”null” button_one_bg_color__hover_enabled=”off” button_one_bg_color__hover=”null” button_two_bg_color__hover_enabled=”off” button_two_bg_color__hover=”null” _builder_version=”3.17.6″][et_pb_slide _builder_version=”3.17.6″ heading=”DiGEN study” button_link=”#” url_new_window=”off” link_option_url_new_window=”off” background_color=”#ffffff” use_background_color_gradient=”off” background_color_gradient_start=”#2b87da” background_color_gradient_end=”#29c4a9″ background_color_gradient_type=”linear” background_color_gradient_direction=”180deg” background_color_gradient_direction_radial=”center” background_color_gradient_start_position=”0%” background_color_gradient_end_position=”100%” background_color_gradient_overlays_image=”off” background_image=”https:\/\/sites.manchester.ac.uk\/digen\/wp-content\/uploads\/sites\/345\/2021\/11\/digen1.png” parallax=”off” parallax_method=”on” background_size=”cover” background_position=”top_left” background_repeat=”no-repeat” background_blend=”normal” allow_player_pause=”off” background_video_pause_outside_viewport=”on” use_bg_overlay=”off” use_text_overlay=”off” text_border_radius=”3″ alignment=”center” child_filter_hue_rotate=”0deg” child_filter_saturate=”100%” child_filter_brightness=”100%” child_filter_contrast=”100%” child_filter_invert=”0%” child_filter_sepia=”0%” child_filter_opacity=”100%” child_filter_blur=”0px” child_mix_blend_mode=”normal” background_layout=”dark” text_shadow_style=”none” header_text_shadow_style=”none” body_text_shadow_style=”none” custom_button=”on” button_bg_color=”#27a2db” button_bg_use_color_gradient=”off” button_bg_color_gradient_overlays_image=”off” button_border_color=”#27a2db” button_use_icon=”on” button_on_hover=”on” button_text_shadow_style=”none” box_shadow_style_button=”none” hover_transition_duration=”300ms” hover_transition_delay=”0ms” hover_transition_speed_curve=”ease” text_shadow_horizontal_length=”0em” text_shadow_vertical_length=”0em” text_shadow_blur_strength=”0em” header_text_shadow_horizontal_length=”0em” header_text_shadow_vertical_length=”0em” header_text_shadow_blur_strength=”0em” body_text_shadow_horizontal_length=”0em” body_text_shadow_vertical_length=”0em” body_text_shadow_blur_strength=”0em” button_text_shadow_horizontal_length=”0em” button_text_shadow_vertical_length=”0em” button_text_shadow_blur_strength=”0em”]<\/p>\n

Dissecting the effects of genomic variants on neurobehavioral dimensions in copy number variations (CNVs) enriched for neuropsychiatric disorders.<\/p>\n

[\/et_pb_slide][\/et_pb_fullwidth_slider][\/et_pb_section][et_pb_section bb_built=”1″ fullwidth=”off” specialty=”off” prev_background_color=”#000000″ next_background_color=”#1d1d1d”][et_pb_row admin_label=”row” allow_player_pause=”off” parallax=”off” parallax_method=”on” parallax_1=”off” parallax_method_1=”off” parallax_2=”off” parallax_method_2=”off” parallax_3=”off” parallax_method_3=”off” make_fullwidth=”off” use_custom_width=”off” width_unit=”on” use_custom_gutter=”off” make_equal=”off” background_position=”top_left” background_repeat=”repeat” background_size=”initial”][et_pb_column type=”1_5″][\/et_pb_column][et_pb_column type=”3_5″][et_pb_text admin_label=”Intro” _builder_version=”3.17.6″]<\/p>\n

DiGEN study<\/h1>\n

The DiGEN study is looking into two genetic disorders: 16p11.2 deletion and duplication, and the impact they have on the mental health and behaviour of children aged 7 to 17 years.<\/p>\n

This study will enable us to learn more about 16p11.2 deletion and duplication and the development of children who have these conditions, which will help us better support families receiving this diagnosis in the future.<\/p>\n

The collection of DNA samples will also help us to understand more about the genetic causes of these conditions.<\/p>\n

[\/et_pb_text][et_pb_divider _builder_version=”3.17.6″ \/][et_pb_text admin_label=”Jumplinks” _builder_version=”3.17.6″]<\/p>\n

On this page:<\/p>\n

    \n
  1. Take part in the study<\/a><\/li>\n
  2. Who is involved?<\/a><\/li>\n
  3. Contact us<\/a><\/li>\n<\/ol>\n

    [\/et_pb_text][et_pb_divider _builder_version=”3.17.6″ \/][\/et_pb_column][et_pb_column type=”1_5″][\/et_pb_column][\/et_pb_row][et_pb_row][et_pb_column type=”4_4″][et_pb_image _builder_version=”3.17.6″ src=”https:\/\/sites.manchester.ac.uk\/digen\/wp-content\/uploads\/sites\/345\/2021\/11\/home-2-2.png” \/][\/et_pb_column][\/et_pb_row][et_pb_row admin_label=”row” allow_player_pause=”off” parallax=”off” parallax_method=”on” parallax_1=”off” parallax_method_1=”off” parallax_2=”off” parallax_method_2=”off” parallax_3=”off” parallax_method_3=”off” make_fullwidth=”off” use_custom_width=”off” width_unit=”on” use_custom_gutter=”off” make_equal=”off” background_position=”top_left” background_repeat=”repeat” background_size=”initial”][et_pb_column type=”1_5″][\/et_pb_column][et_pb_column type=”3_5″][et_pb_text admin_label=”Take part in the study” _builder_version=”3.17.6″]<\/p>\n

    \u00a0<\/h2>\n

    Take part in the study<\/h2>\n

    Our study allows the whole family to take part. Everyone will be asked to complete a questionnaire, and participate in an interview with our research team.<\/p>\n

    Your children will also complete some fun computerised activities and then we will ask each family member to provide us with saliva and\/or blood samples.<\/p>\n

    We are recruiting participants in collaboration with a team of geneticists at Royal Manchester Children\u2019s Hospital.<\/p>\n

    Alternatively, if your child is aged between 7 and 17 years and has a diagnosis of 16p11.2 deletion or duplication, and you would like to get involved in the study, please email digen@mft.nhs.uk<\/a> for more information.<\/p>\n

    [\/et_pb_text][et_pb_text admin_label=”Back to top” _builder_version=”3.17.6″]<\/p>\n

    \n< Back to top<\/a><\/p>\n

     <\/p>\n

    [\/et_pb_text][\/et_pb_column][et_pb_column type=”1_5″][\/et_pb_column][\/et_pb_row][et_pb_row][et_pb_column type=”4_4″][et_pb_divider _builder_version=”3.17.6″ \/][\/et_pb_column][\/et_pb_row][et_pb_row admin_label=”row” allow_player_pause=”off” parallax=”off” parallax_method=”on” parallax_1=”off” parallax_method_1=”off” parallax_2=”off” parallax_method_2=”off” parallax_3=”off” parallax_method_3=”off” make_fullwidth=”off” use_custom_width=”off” width_unit=”on” use_custom_gutter=”off” make_equal=”off” background_position=”top_left” background_repeat=”repeat” background_size=”initial”][et_pb_column type=”1_5″][\/et_pb_column][et_pb_column type=”3_5″][et_pb_text admin_label=”Who” _builder_version=”3.17.6″]<\/p>\n

    \u00a0<\/h2>\n

    Who is involved with the study?<\/h2>\n

    This study is a collaboration between the team at Manchester University NHS Foundation Trust and the team in the Division of Psychological Medicine and Clinical Neurosciences at Cardiff University.<\/p>\n

    The principal investigators are Professor Jonathan Green (Manchester) and Professor Marianne van den Bree (Cardiff).<\/p>\n

    The families who take part will be working closely with our research assistants, Charlotte Butter and Caitlin Goldie, from The University of Manchester, as well as the Cardiff University research team.<\/p>\n

    [\/et_pb_text][et_pb_text admin_label=”Back to top” _builder_version=”3.17.6″]<\/p>\n

    \n< Back to top<\/a><\/p>\n

     <\/p>\n

    [\/et_pb_text][\/et_pb_column][et_pb_column type=”1_5″][\/et_pb_column][\/et_pb_row][et_pb_row admin_label=”row” allow_player_pause=”off” parallax=”off” parallax_method=”on” parallax_1=”off” parallax_method_1=”off” parallax_2=”off” parallax_method_2=”off” parallax_3=”off” parallax_method_3=”off” make_fullwidth=”off” use_custom_width=”off” width_unit=”on” use_custom_gutter=”off” make_equal=”off” background_position=”top_left” background_repeat=”repeat” background_size=”initial”][et_pb_column type=”4_4″][et_pb_divider _builder_version=”3.17.6″ \/][\/et_pb_column][\/et_pb_row][et_pb_row admin_label=”row” allow_player_pause=”off” parallax=”off” parallax_method=”on” parallax_1=”off” parallax_method_1=”off” parallax_2=”off” parallax_method_2=”off” parallax_3=”off” parallax_method_3=”off” make_fullwidth=”off” use_custom_width=”off” width_unit=”on” use_custom_gutter=”off” make_equal=”off” background_position=”top_left” background_repeat=”repeat” background_size=”initial”][et_pb_column type=”1_5″][\/et_pb_column][et_pb_column type=”3_5″][et_pb_text admin_label=”Contact” _builder_version=”3.17.6″]<\/p>\n

    \u00a0<\/h2>\n

    Contact us<\/h2>\n

    If you have any questions about the study, please email us:<\/p>\n

    Email:\u00a0digen@mft.nhs.uk<\/a><\/p>\n

    You can also contact our Manchester-based research assistants by phone:<\/p>\n

    Charlotte Butter<\/strong>
    Tel:\u00a007392860082<\/p>\n

    Caitlin Goldie<\/strong>
    Tel: 07584106034<\/p>\n

    [\/et_pb_text][et_pb_text admin_label=”Back to top” _builder_version=”3.17.6″]<\/p>\n

    \n< Back to top<\/a><\/p>\n

     <\/p>\n

    [\/et_pb_text][\/et_pb_column][et_pb_column type=”1_5″][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section bb_built=”1″ admin_label=”Connect Title” custom_padding=”0px||0px|” _builder_version=”3.0.90″ background_color=”#1d1d1d” module_class=”footer-section” prev_background_color=”#ffffff” global_module=”380″][et_pb_row admin_label=”row” global_parent=”380″ locked=”off” allow_player_pause=”off” parallax=”off” parallax_method=”on” parallax_1=”off” parallax_method_1=”off” parallax_2=”off” parallax_method_2=”off” parallax_3=”off” parallax_method_3=”off” make_fullwidth=”off” use_custom_width=”off” width_unit=”on” use_custom_gutter=”off” make_equal=”off” module_id=”footer-row” _builder_version=”3.0.89″][et_pb_column type=”1_3″][et_pb_text admin_label=”Contact Us Title” global_parent=”380″ background_layout=”dark” text_text_color=”#ffffff” parent_locked=”off” background_position=”top_left” background_repeat=”repeat” background_size=”initial”]<\/p>\n

    Contact Us<\/h4>\n

    [\/et_pb_text][et_pb_text admin_label=”Contact Us” global_parent=”380″ text_text_color=”#aaaaaa” parent_locked=”off” background_layout=”light” text_orientation=”left” use_border_color=”off” border_color=”#ffffff” border_style=”solid” module_class=”contact-us” background_position=”top_left” background_repeat=”repeat” background_size=”initial”]<\/p>\n

    +44 (0) 161 306 6000<\/p>\n

    [\/et_pb_text][\/et_pb_column][et_pb_column type=”1_3″][et_pb_text admin_label=”Find Us Title” global_parent=”380″ background_layout=”dark” text_text_color=”#ffffff” parent_locked=”off” background_position=”top_left” background_repeat=”repeat” background_size=”initial”]<\/p>\n

    Find Us<\/h4>\n

    [\/et_pb_text][et_pb_text admin_label=”Address” global_parent=”380″ background_layout=”dark” text_orientation=”left” use_border_color=”off” border_color=”#ffffff” border_style=”solid” module_id=”address” parent_locked=”off” background_position=”top_left” background_repeat=”repeat” background_size=”initial”]<\/p>\n

    The University of Manchester
    Oxford Rd
    Manchester
    M13 9PL
    UK<\/a><\/p>\n

    [\/et_pb_text][\/et_pb_column][et_pb_column type=”1_3″][et_pb_text admin_label=”Connect Title” global_parent=”380″ background_layout=”dark” text_text_color=”#ffffff” parent_locked=”off” background_position=”top_left” background_repeat=”repeat” background_size=”initial”]<\/p>\n

    Connect With Us<\/h4>\n

    [\/et_pb_text][et_pb_code admin_label=”Social Media” global_parent=”380″ parent_locked=”off” _builder_version=”3.17.6″]<\/p>\n