{"id":2234,"date":"2026-06-11T10:43:20","date_gmt":"2026-06-11T09:43:20","guid":{"rendered":"https:\/\/sites.manchester.ac.uk\/health-research-from-home\/?p=2234"},"modified":"2026-06-11T10:43:20","modified_gmt":"2026-06-11T09:43:20","slug":"predicting-multiple-sclerosis-symptoms-using-machine-learning","status":"publish","type":"post","link":"https:\/\/sites.manchester.ac.uk\/health-research-from-home\/2026\/06\/11\/predicting-multiple-sclerosis-symptoms-using-machine-learning\/","title":{"rendered":"Predicting multiple sclerosis symptoms using machine learning"},"content":{"rendered":"<p>[et_pb_section bb_built=&#8221;1&#8243; admin_label=&#8221;section&#8221; fullwidth=&#8221;on&#8221; next_background_color=&#8221;#000000&#8243; global_module=&#8221;322&#8243;][et_pb_fullwidth_menu global_parent=&#8221;322&#8243; _builder_version=&#8221;3.0.106&#8243; menu_id=&#8221;7&#8243; submenu_direction=&#8221;downwards&#8221; fullwidth_menu=&#8221;off&#8221; background_layout=&#8221;dark&#8221; module_class=&#8221;main-navigation&#8221; \/][\/et_pb_section][et_pb_section bb_built=&#8221;1&#8243; fullwidth=&#8221;off&#8221; specialty=&#8221;on&#8221; prev_background_color=&#8221;#000000&#8243; next_background_color=&#8221;#1d1d1d&#8221;][et_pb_column type=&#8221;2_3&#8243; specialty_columns=&#8221;2&#8243;][et_pb_row_inner locked=&#8221;off&#8221;][et_pb_column_inner type=&#8221;4_4&#8243; saved_specialty_column_type=&#8221;2_3&#8243;][et_pb_post_title _builder_version=&#8221;3.17.6&#8243; featured_placement=&#8221;above&#8221; locked=&#8221;on&#8221; parent_locked=&#8221;off&#8221; date_format=&#8221;j M Y&#8221; \/][et_pb_text _builder_version=&#8221;3.17.6&#8243; background_layout=&#8221;light&#8221; parent_locked=&#8221;off&#8221;]<\/p>\n<p class=\"paragraph ng-attr-widget\">Multiple sclerosis (MS) affects around 2.8 million people worldwide. People living with MS can experience many symptoms, including neurological symptoms affecting cognitive function and movement, depression, fatigue and poor sleep. Some symptoms can be managed, but because clinic visits are often infrequent, treatment can sometimes lag behind what people need.<\/p>\n<p class=\"paragraph ng-attr-widget\">Smartphones and wearables can track various aspects of health passively and continuously. This creates an opportunity to use data from people&#8217;s devices to predict when symptoms might worsen. The month&#8217;s Tap into Research looks at a study testing whether machine learning models can predict short-term changes in MS symptoms using data from smartphones, wearables, and self-reported questionnaires.<\/p>\n<h2 class=\"paragraph ng-attr-widget\">How were smartphones and wearables used in the study?<\/h2>\n<p class=\"paragraph ng-attr-widget\">Participants took part for 12-24 weeks and used their own smartphones. The research team collected call activity, location, and screen use. Participants also wore Fitbits provided by the study, which measured heart rate, step count, and sleep patterns.<\/p>\n<p class=\"paragraph ng-attr-widget\">Alongside this passive monitoring, participants completed a short symptom questionnaire on their smartphone three times per day.<\/p>\n<p class=\"paragraph ng-attr-widget\">Every 2 weeks, participants completed a validated questionnaire on depressive symptoms. Every 4 weeks, they completed questionnaires on neurological symptoms, fatigue, and sleep quality. These questionnaires were used as the &#8220;gold standard&#8221; to judge how well the models predicted symptoms.<\/p>\n<h2 class=\"paragraph ng-attr-widget\">What did the study find?<\/h2>\n<p class=\"paragraph ng-attr-widget\">Models that included smartphone and wearable data were better at predicting short term worsening in depression, neurological symptoms, fatigue, and sleep quality than models that did not use this data.<\/p>\n<p class=\"paragraph ng-attr-widget\">The study also found:<\/p>\n<ul>\n<li class=\"paragraph ng-attr-widget\">Using smartphone and Fitbit measurements from the period just before symptom rating gave the best predictions for depression, neurological symptoms, and sleep quality.<\/li>\n<li class=\"paragraph ng-attr-widget\">For fatigue, also including data from further back in time improved predictions.<\/li>\n<li class=\"paragraph ng-attr-widget\">For three of the four symptoms, adding the daily self-reported questionnaires did not improve predictions. The exception was depression: the question \u201cHow depressed do you feel?\u201d helped predict future depressive symptoms.<\/li>\n<\/ul>\n<h2 class=\"paragraph ng-attr-widget\">Why does this matter?<\/h2>\n<p class=\"paragraph ng-attr-widget\">This study shows that data collected from smartphones and wearables during everyday life can help predict when MS symptoms might worsen. This could allow people with MS to monitor their symptoms more easily at home and help clinicians provide the right support at the right time.<br \/>Future research could explore how well this approach works outside a study setting, where people would need to keep using their devices, without the close monitoring that helped maintain adherence during the study.<\/p>\n<p>Read the paper:\u00a0<a href=\"https:\/\/www.jmir.org\/2025\/1\/e70871\/\">Longitudinal digital phenotyping of multiple sclerosis severity using passively sensed behaviors and ecological momentary assessments: real-world evaluation<\/a><\/p>\n<p>[\/et_pb_text][et_pb_post_nav _builder_version=&#8221;3.0.106&#8243; in_same_term=&#8221;off&#8221; show_prev=&#8221;on&#8221; show_next=&#8221;on&#8221; prev_text=&#8221;Previous&#8221; next_text=&#8221;Next&#8221; locked=&#8221;on&#8221; parent_locked=&#8221;off&#8221; \/][et_pb_comments _builder_version=&#8221;3.0.106&#8243; show_avatar=&#8221;on&#8221; show_reply=&#8221;on&#8221; show_count=&#8221;on&#8221; background_layout=&#8221;light&#8221; header_font_size_tablet=&#8221;51&#8243; header_line_height_tablet=&#8221;2&#8243; custom_button=&#8221;on&#8221; button_icon_placement=&#8221;right&#8221; button_text_color=&#8221;#ffffff&#8221; button_use_icon=&#8221;off&#8221; locked=&#8221;on&#8221; parent_locked=&#8221;off&#8221; button_text_size__hover_enabled=&#8221;off&#8221; button_text_size__hover=&#8221;null&#8221; button_one_text_size__hover_enabled=&#8221;off&#8221; button_one_text_size__hover=&#8221;null&#8221; button_two_text_size__hover_enabled=&#8221;off&#8221; button_two_text_size__hover=&#8221;null&#8221; button_text_color__hover_enabled=&#8221;off&#8221; button_text_color__hover=&#8221;null&#8221; button_one_text_color__hover_enabled=&#8221;off&#8221; button_one_text_color__hover=&#8221;null&#8221; button_two_text_color__hover_enabled=&#8221;off&#8221; button_two_text_color__hover=&#8221;null&#8221; button_border_width__hover_enabled=&#8221;off&#8221; button_border_width__hover=&#8221;null&#8221; button_one_border_width__hover_enabled=&#8221;off&#8221; button_one_border_width__hover=&#8221;null&#8221; button_two_border_width__hover_enabled=&#8221;off&#8221; button_two_border_width__hover=&#8221;null&#8221; button_border_color__hover_enabled=&#8221;off&#8221; button_border_color__hover=&#8221;null&#8221; button_one_border_color__hover_enabled=&#8221;off&#8221; button_one_border_color__hover=&#8221;null&#8221; button_two_border_color__hover_enabled=&#8221;off&#8221; button_two_border_color__hover=&#8221;null&#8221; button_border_radius__hover_enabled=&#8221;off&#8221; button_border_radius__hover=&#8221;null&#8221; button_one_border_radius__hover_enabled=&#8221;off&#8221; button_one_border_radius__hover=&#8221;null&#8221; button_two_border_radius__hover_enabled=&#8221;off&#8221; button_two_border_radius__hover=&#8221;null&#8221; button_letter_spacing__hover_enabled=&#8221;off&#8221; button_letter_spacing__hover=&#8221;null&#8221; button_one_letter_spacing__hover_enabled=&#8221;off&#8221; button_one_letter_spacing__hover=&#8221;null&#8221; button_two_letter_spacing__hover_enabled=&#8221;off&#8221; button_two_letter_spacing__hover=&#8221;null&#8221; button_bg_color__hover_enabled=&#8221;off&#8221; button_bg_color__hover=&#8221;null&#8221; button_one_bg_color__hover_enabled=&#8221;off&#8221; button_one_bg_color__hover=&#8221;null&#8221; button_two_bg_color__hover_enabled=&#8221;off&#8221; button_two_bg_color__hover=&#8221;null&#8221; \/][et_pb_text admin_label=&#8221;Related posts&#8221; _builder_version=&#8221;3.0.106&#8243; background_layout=&#8221;light&#8221; locked=&#8221;on&#8221; parent_locked=&#8221;off&#8221;]<\/p>\n<h1>Related<\/h1>\n<!-- relpost-thumb-wrapper --><div class=\"relpost-thumb-wrapper\"><!-- filter-class --><div class=\"relpost-thumb-container\"><h3>Related posts:<\/h3><div style=\"clear: both\"><\/div><div style=\"clear: both\"><\/div><!-- relpost-block-container --><div class=\"relpost-block-container relpost-block-column-layout\" style=\"--relposth-columns: 3;--relposth-columns_t: 2; --relposth-columns_m: 2\"><a href=\"https:\/\/sites.manchester.ac.uk\/health-research-from-home\/2026\/10\/08\/understanding-the-link-between-emotional-regulation-and-perinatal-depression\/\"class=\"relpost-block-single\" ><div class=\"relpost-custom-block-single\"><div class=\"relpost-block-single-image rpt-lazyload\" aria-label=\"An illustration of someone holding a phone with the text &#039;Tap Into Research&#039; next to it.\" role=\"img\" data-bg=\"https:\/\/sites.manchester.ac.uk\/health-research-from-home\/wp-content\/uploads\/sites\/463\/2026\/06\/tap-into-research_1400x500-150x150.jpg\" style=\"background: transparent no-repeat scroll 0% 0%; width: 150px; height: 150px; aspect-ratio: 1\/1;\"><\/div><div class=\"relpost-block-single-text\"  style=\"height: 75px;font-family: Arial;  font-size: 12px;  color: #333333;\"><h2 class=\"relpost_card_title\">Understanding the link between emotional regulation and perinatal depression<\/h2><\/div><\/div><\/a><a href=\"https:\/\/sites.manchester.ac.uk\/health-research-from-home\/2025\/09\/01\/from-screen-time-to-symptom-tracking-what-smartphones-can-tell-us-about-depression\/\"class=\"relpost-block-single\" ><div class=\"relpost-custom-block-single\"><div class=\"relpost-block-single-image rpt-lazyload\" aria-label=\"An illustration of someone holding a phone with the text &#039;Tap Into Research&#039; next to it.\" role=\"img\" data-bg=\"https:\/\/sites.manchester.ac.uk\/health-research-from-home\/wp-content\/uploads\/sites\/463\/2025\/05\/tap-into-research-150x150.png\" style=\"background: transparent no-repeat scroll 0% 0%; width: 150px; height: 150px; aspect-ratio: 1\/1;\"><\/div><div class=\"relpost-block-single-text\"  style=\"height: 75px;font-family: Arial;  font-size: 12px;  color: #333333;\"><h2 class=\"relpost_card_title\">From screen time to symptom tracking: what smartphones can tell us about depression<\/h2><\/div><\/div><\/a><a href=\"https:\/\/sites.manchester.ac.uk\/health-research-from-home\/2026\/01\/03\/tracking-rheumatoid-arthritis-flares-with-wearable-devices\/\"class=\"relpost-block-single\" ><div class=\"relpost-custom-block-single\"><div class=\"relpost-block-single-image rpt-lazyload\" aria-label=\"An illustration of someone holding a phone with the text &#039;Tap Into Research&#039; next to it.\" role=\"img\" data-bg=\"https:\/\/sites.manchester.ac.uk\/health-research-from-home\/wp-content\/uploads\/sites\/463\/2025\/05\/tap-into-research-150x150.png\" style=\"background: transparent no-repeat scroll 0% 0%; width: 150px; height: 150px; aspect-ratio: 1\/1;\"><\/div><div class=\"relpost-block-single-text\"  style=\"height: 75px;font-family: Arial;  font-size: 12px;  color: #333333;\"><h2 class=\"relpost_card_title\">Tracking rheumatoid arthritis flares with wearable devices<\/h2><\/div><\/div><\/a><\/div><!-- close relpost-block-container --><div style=\"clear: both\"><\/div><\/div><!-- close filter class --><\/div><!-- close relpost-thumb-wrapper -->\n<p>[\/et_pb_text][\/et_pb_column_inner][\/et_pb_row_inner][\/et_pb_column][et_pb_column type=&#8221;1_3&#8243;][et_pb_sidebar _builder_version=&#8221;3.0.106&#8243; area=&#8221;sidebar-1&#8243; orientation=&#8221;left&#8221; show_border=&#8221;off&#8221; background_layout=&#8221;light&#8221; locked=&#8221;on&#8221; \/][\/et_pb_column][\/et_pb_section][et_pb_section bb_built=&#8221;1&#8243; admin_label=&#8221;Connect Title&#8221; custom_padding=&#8221;0px||0px|&#8221; _builder_version=&#8221;3.0.90&#8243; background_color=&#8221;#1d1d1d&#8221; module_class=&#8221;footer-section&#8221; prev_background_color=&#8221;#ffffff&#8221; global_module=&#8221;380&#8243;][et_pb_row admin_label=&#8221;row&#8221; global_parent=&#8221;380&#8243; locked=&#8221;off&#8221; allow_player_pause=&#8221;off&#8221; parallax=&#8221;off&#8221; parallax_method=&#8221;on&#8221; parallax_1=&#8221;off&#8221; parallax_method_1=&#8221;off&#8221; parallax_2=&#8221;off&#8221; parallax_method_2=&#8221;off&#8221; parallax_3=&#8221;off&#8221; parallax_method_3=&#8221;off&#8221; make_fullwidth=&#8221;off&#8221; use_custom_width=&#8221;off&#8221; width_unit=&#8221;on&#8221; use_custom_gutter=&#8221;off&#8221; make_equal=&#8221;off&#8221; module_id=&#8221;footer-row&#8221; _builder_version=&#8221;3.0.89&#8243;][et_pb_column type=&#8221;1_3&#8243;][et_pb_text admin_label=&#8221;Contact Us Title&#8221; global_parent=&#8221;380&#8243; background_layout=&#8221;dark&#8221; text_text_color=&#8221;#ffffff&#8221; parent_locked=&#8221;off&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; background_size=&#8221;initial&#8221; _builder_version=&#8221;3.17.6&#8243;]<\/p>\n<h4>Contact Us<\/h4>\n<p>[\/et_pb_text][et_pb_text admin_label=&#8221;Contact Us&#8221; global_parent=&#8221;380&#8243; text_text_color=&#8221;#aaaaaa&#8221; parent_locked=&#8221;off&#8221; background_layout=&#8221;light&#8221; text_orientation=&#8221;left&#8221; use_border_color=&#8221;off&#8221; module_class=&#8221;contact-us&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; background_size=&#8221;initial&#8221; _builder_version=&#8221;3.17.6&#8243;]<\/p>\n<p>Email:\u00a0<a href=\"mailto:hrfh@manchester.ac.uk\">hrfh@manchester.ac.uk<\/a><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-1747\" src=\"https:\/\/sites.manchester.ac.uk\/health-research-from-home\/wp-content\/uploads\/sites\/463\/2024\/09\/HRfH-Symbol-RGB-MEDIUM-300x300.png\" alt=\"\" width=\"90\" height=\"90\" srcset=\"https:\/\/sites.manchester.ac.uk\/health-research-from-home\/wp-content\/uploads\/sites\/463\/2024\/09\/HRfH-Symbol-RGB-MEDIUM-300x300.png 300w, https:\/\/sites.manchester.ac.uk\/health-research-from-home\/wp-content\/uploads\/sites\/463\/2024\/09\/HRfH-Symbol-RGB-MEDIUM-150x150.png 150w, https:\/\/sites.manchester.ac.uk\/health-research-from-home\/wp-content\/uploads\/sites\/463\/2024\/09\/HRfH-Symbol-RGB-MEDIUM-768x768.png 768w, https:\/\/sites.manchester.ac.uk\/health-research-from-home\/wp-content\/uploads\/sites\/463\/2024\/09\/HRfH-Symbol-RGB-MEDIUM-250x250.png 250w, https:\/\/sites.manchester.ac.uk\/health-research-from-home\/wp-content\/uploads\/sites\/463\/2024\/09\/HRfH-Symbol-RGB-MEDIUM-350x350.png 350w, https:\/\/sites.manchester.ac.uk\/health-research-from-home\/wp-content\/uploads\/sites\/463\/2024\/09\/HRfH-Symbol-RGB-MEDIUM.png 1000w\" sizes=\"(max-width: 90px) 100vw, 90px\" \/><\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_3&#8243;][et_pb_text admin_label=&#8221;Find Us Title&#8221; global_parent=&#8221;380&#8243; background_layout=&#8221;dark&#8221; text_text_color=&#8221;#ffffff&#8221; parent_locked=&#8221;off&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; background_size=&#8221;initial&#8221;]<\/p>\n<h4>Find Us<\/h4>\n<p>[\/et_pb_text][et_pb_text admin_label=&#8221;Address&#8221; global_parent=&#8221;380&#8243; background_layout=&#8221;dark&#8221; text_orientation=&#8221;left&#8221; use_border_color=&#8221;off&#8221; module_id=&#8221;address&#8221; parent_locked=&#8221;off&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; background_size=&#8221;initial&#8221; _builder_version=&#8221;3.17.6&#8243;]<\/p>\n<p><a href=\"https:\/\/www.manchester.ac.uk\/about\/maps\/interactive-map\/?id=736\">3rd Floor<br \/>Christabel Pankhurst Institute<br \/>Dover Street<br \/>Manchester<br \/>M13 9PS<br \/>UK<\/a><\/p>\n<p>\u00a0<\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_3&#8243;][et_pb_text admin_label=&#8221;Connect Title&#8221; global_parent=&#8221;380&#8243; background_layout=&#8221;dark&#8221; text_text_color=&#8221;#ffffff&#8221; parent_locked=&#8221;off&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; background_size=&#8221;initial&#8221;]<\/p>\n<h4>Connect With Us<\/h4>\n<p>[\/et_pb_text][et_pb_code admin_label=&#8221;Social Media&#8221; global_parent=&#8221;380&#8243; parent_locked=&#8221;off&#8221; _builder_version=&#8221;3.17.6&#8243;]<\/p>\n<ul class=\"inlineList footer-socialIcons\"><!-- [et_pb_line_break_holder] --><\/p>\n<li><!-- [et_pb_line_break_holder] --> <a href=\"https:\/\/www.linkedin.com\/company\/health-research-from-home\/?viewAsMember=true\"><!-- [et_pb_line_break_holder] --> <img loading=\"lazy\" decoding=\"async\" src=\"\/\/assets.manchester.ac.uk\/phase1\/templates\/images\/icon-linkedin-R-54.png\" alt=\"LinkedIn page for Health Research from Home\" width=\"49\" height=\"49\" \/><!-- [et_pb_line_break_holder] --> <\/a><!-- [et_pb_line_break_holder] --><\/li>\n<p><!-- [et_pb_line_break_holder] --><\/p>\n<li><!-- [et_pb_line_break_holder] --> <a href=\"https:\/\/www.youtube.com\/@HealthResearchfromHome\"><!-- [et_pb_line_break_holder] --> <img loading=\"lazy\" decoding=\"async\" src=\"\/\/assets.manchester.ac.uk\/phase1\/templates\/images\/icon-youtube-50.png\" alt=\"YouTube page for Health Research from Home\" width=\"40\" height=\"40\" \/><!-- [et_pb_line_break_holder] --> <\/a><!-- [et_pb_line_break_holder] --><\/li>\n<p><!-- [et_pb_line_break_holder] --><\/ul>\n<p><!-- [et_pb_line_break_holder] --><!-- [et_pb_line_break_holder] --><a href=\"https:\/\/emarketing.manchester.ac.uk\/l\/166\/hrfhsubscribe\">Subscribe to our newsletter<\/a><!\u2013- [et_pb_br_holder] -\u2013><!-- [et_pb_line_break_holder] --><!-- [et_pb_line_break_holder] --><a href=\"https:\/\/documents.manchester.ac.uk\/display.aspx?DocID=74034\">HRfH Privacy Notice<\/a><!-- [et_pb_line_break_holder] --><!-- [et_pb_line_break_holder] -->[\/et_pb_code][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Multiple sclerosis (MS) affects around 2.8 million people worldwide. People living with MS can experience many symptoms, including neurological symptoms affecting cognitive function and movement, depression, fatigue and poor sleep. Some symptoms can be managed, but because clinic visits are often infrequent, treatment can sometimes lag behind what people need.Smartphones and wearables can track various [&hellip;]<\/p>\n","protected":false},"author":792,"featured_media":1961,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","_exactmetrics_skip_tracking":false,"footnotes":""},"categories":[11],"tags":[],"class_list":["post-2234","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-tap-into-research"],"_links":{"self":[{"href":"https:\/\/sites.manchester.ac.uk\/health-research-from-home\/wp-json\/wp\/v2\/posts\/2234","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.manchester.ac.uk\/health-research-from-home\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sites.manchester.ac.uk\/health-research-from-home\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/sites.manchester.ac.uk\/health-research-from-home\/wp-json\/wp\/v2\/users\/792"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.manchester.ac.uk\/health-research-from-home\/wp-json\/wp\/v2\/comments?post=2234"}],"version-history":[{"count":3,"href":"https:\/\/sites.manchester.ac.uk\/health-research-from-home\/wp-json\/wp\/v2\/posts\/2234\/revisions"}],"predecessor-version":[{"id":2244,"href":"https:\/\/sites.manchester.ac.uk\/health-research-from-home\/wp-json\/wp\/v2\/posts\/2234\/revisions\/2244"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/sites.manchester.ac.uk\/health-research-from-home\/wp-json\/wp\/v2\/media\/1961"}],"wp:attachment":[{"href":"https:\/\/sites.manchester.ac.uk\/health-research-from-home\/wp-json\/wp\/v2\/media?parent=2234"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sites.manchester.ac.uk\/health-research-from-home\/wp-json\/wp\/v2\/categories?post=2234"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sites.manchester.ac.uk\/health-research-from-home\/wp-json\/wp\/v2\/tags?post=2234"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}