{"id":2510,"date":"2022-09-20T13:24:49","date_gmt":"2022-09-20T12:24:49","guid":{"rendered":"https:\/\/sites.manchester.ac.uk\/lydia-becker-institute-blog\/?page_id=2510"},"modified":"2024-10-17T10:14:50","modified_gmt":"2024-10-17T09:14:50","slug":"research","status":"publish","type":"page","link":"https:\/\/sites.manchester.ac.uk\/lydia-becker-institute\/research\/","title":{"rendered":"Research"},"content":{"rendered":"

[et_pb_section bb_built=”1″ admin_label=”section” fullwidth=”on” next_background_color=”#000000″ global_module=”322″][et_pb_fullwidth_menu global_parent=”322″ _builder_version=”3.0.106″ menu_id=”7″ submenu_direction=”downwards” fullwidth_menu=”off” background_layout=”dark” module_class=”main-navigation” \/][\/et_pb_section][et_pb_section bb_built=”1″ fullwidth=”off” specialty=”off” transparent_background=”off” allow_player_pause=”off” inner_shadow=”off” parallax=”off” parallax_method=”on” make_fullwidth=”off” use_custom_width=”off” width_unit=”on” make_equal=”off” use_custom_gutter=”off” custom_padding=”0px||0px|” custom_css_main_element=”padding-top:0px” module_class=”header-image-section” prev_background_color=”#ffffff” next_background_color=”#ffffff”][et_pb_row allow_player_pause=”off” parallax=”off” parallax_method=”on” parallax_1=”off” parallax_method_1=”off” make_fullwidth=”off” use_custom_width=”off” width_unit=”on” use_custom_gutter=”off” make_equal=”off” custom_margin=”||0px|” custom_padding=”||0px|” module_class=”header-image” background_position=”top_left” background_repeat=”repeat” background_size=”initial”][et_pb_column type=”4_4″][et_pb_image src=”https:\/\/sites.manchester.ac.uk\/lydia-becker-institute-blog\/wp-content\/uploads\/sites\/69\/2022\/09\/white-blood-cells-attack-cancer-cell.jpg” show_in_lightbox=”off” url_new_window=”off” use_overlay=”off” align=”left” always_center_on_mobile=”on” use_border_color=”off” force_fullwidth=”off” custom_margin=”0px|||” animation_direction=”left” show_bottom_space=”off” border_color_all=”#ffffff” _builder_version=”3.17.6″ \/][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section bb_built=”1″ fullwidth=”off” specialty=”off” transparent_background=”off” allow_player_pause=”off” inner_shadow=”off” parallax=”off” parallax_method=”on” make_fullwidth=”off” use_custom_width=”off” width_unit=”on” make_equal=”off” use_custom_gutter=”off” custom_padding=”||0px|” prev_background_color=”#ffffff” next_background_color=”#ffffff”][et_pb_row allow_player_pause=”off” parallax=”off” parallax_method=”on” parallax_1=”off” parallax_method_1=”off” make_fullwidth=”off” use_custom_width=”off” width_unit=”on” use_custom_gutter=”off” make_equal=”off” custom_margin=”||0px|” custom_padding=”||0px|” module_class=”breadcrumbs-row” background_position=”top_left” background_repeat=”repeat” background_size=”initial”][et_pb_column type=”4_4″][et_pb_text background_layout=”light” text_orientation=”left” use_border_color=”off” border_color=”#ffffff” border_style=”solid” module_class=”breadcrumbs” custom_css_main_element=”border-bottom: 1px solid #ececed;” module_alignment=”left” background_position=”top_left” background_repeat=”repeat” background_size=”initial”]<\/p>\nLydia Becker Institute of Immunology and Inflammation<\/a><\/span><\/span>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section bb_built=”1″ fullwidth=”off” specialty=”on” transparent_background=”off” allow_player_pause=”off” inner_shadow=”off” parallax=”off” parallax_method=”on” parallax_1=”off” parallax_method_1=”off” parallax_2=”off” parallax_method_2=”off” make_fullwidth=”off” use_custom_width=”off” width_unit=”on” make_equal=”off” use_custom_gutter=”on” gutter_width=”2″ prev_background_color=”#ffffff” next_background_color=”#1d1d1d”][et_pb_column type=”1_3″][et_pb_sidebar area=”et_pb_widget_area_1″ orientation=”left” remove_border=”on” background_layout=”light” module_id=”left-nav-menu” show_border=”off” \/][\/et_pb_column][et_pb_column type=”2_3″ specialty_columns=”2″][et_pb_row_inner admin_label=”Row”][et_pb_column_inner type=”4_4″ saved_specialty_column_type=”2_3″][et_pb_text admin_label=”Text: Research intro” _builder_version=”3.17.6″]<\/p>\n

Research<\/h1>\n

Our immune system is at the heart of a vast array of different diseases. The Institute draws together internationally renowned basic and clinical expertise.<\/p>\n

By housing creative excellence across scientific and clinical disciplines, we remove traditional boundaries to find solutions for today\u2019s global disease challenges.<\/p>\n

We are training future scientific leaders to work across these boundaries and have a powerful cohort of early career fellows, several of whom are holders of Wellcome Trust and Sir Henry Dale Fellowship awards.<\/p>\n

Our basic scientists and clinicians are developing an understanding of immunological and inflammatory processes in order to improve clinical treatments for patients.<\/p>\n

Major research activities<\/h2>\n

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\"MRA<\/p>\n

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Barrier immunology<\/h3>\n

The University has a critical mass of academics researching health and disease at barrier surfaces. Our research covers lung, gastrointestinal, skin, and oral cavity immunology.<\/p>\n

Lead: Dr Joanne Konkel<\/p>\n<\/div>\n<\/div>\n

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\"Cancer<\/p>\n

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Cancer immunology<\/h3>\n

Cancer immunology is revolutionising the treatment of cancer. Our basic researchers and medical oncologists are expanding our knowledge of the power of the immune system in fighting disease.<\/p>\n

Leads: Professor Robert Bristow, Dr Santiago Zelenay, Dr Anne Armstrong<\/p>\n<\/div>\n<\/div>\n

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\"Cardiovascular<\/p>\n

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Cardiovascular immunology and multi-morbidities<\/h3>\n

Inflammation is a recognised feature of obesity-related diseases yet it is relatively unexplored.<\/p>\n

Lead: Professor Ashraf Kitmitto<\/p>\n<\/div>\n<\/div>\n

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\"T<\/p>\n

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Cellular immunology<\/h3>\n

Our internationally leading experts are studying the ways different immune cells work together to detect and deal with pathogens including bacteria, viruses, fungi or parasites, and in cancer.<\/p>\n

Lead: Dr Gloria L\u00f3pez-Castej\u00f3n<\/p>\n<\/div>\n<\/div>\n

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\"Close-up<\/p>\n

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Eco-immunology and context-specific immunology<\/h3>\n

Understanding the impact of different (and combinations of) variables on how the immune system operates will bring benefits to multiple fields.<\/p>\n

Lead: Professor Kathryn Else<\/p>\n<\/div>\n<\/div>\n

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\"Immune<\/p>\n

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Immune tolerance<\/h3>\n

We are increasing the understanding of how a breakdown of immune tolerance results in debilitating inflammatory disease, and translating scientific discoveries into the clinic to improve the management of these conditions.<\/p>\n

Lead: Dr Matthew Hepworth<\/p>\n<\/div>\n<\/div>\n

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\"Virus<\/p>\n

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Immuno-informatics<\/h3>\n

Immuno-informatics research at Manchester builds on our expertise to create frameworks that integrate immunological data from the cell to populations.<\/p>\n

Lead: Professor Andy Brass<\/p>\n<\/div>\n<\/div>\n

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\"Parkinson's<\/p>\n

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Immuno-matrix<\/h3>\n

Our research is delivering new insights into the interconnectivity between matrix and immune function, with major implications for treatment of chronic diseases and understanding host\u2013pathogen interactions.<\/p>\n

Lead: Professor Judi Allen<\/p>\n<\/div>\n<\/div>\n

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\"Mycoplasma<\/p>\n

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Life course immunology<\/h3>\n

Half of all paediatric hospital admissions are due to infectious disease. Our academics are working with paediatricians and nurses to unravel childhood immunity and tailor treatments to this age group.<\/p>\n

Lead: Dr Peter Arkwright<\/p>\n<\/div>\n<\/div>\n

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\"Parkinson's<\/p>\n

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Neuro-immunology<\/h3>\n

Our strengths in immunology and neurology combine to perform fundamental and applied research into mental health, Alzheimer\u2019s, dementia, epilepsy and, at the Geoffrey Jefferson Brain Research Centre, stroke and brain tumours.<\/p>\n

Lead: Dr Andy Greenhalgh<\/p>\n<\/div>\n<\/div>\n

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\"Pathogenic<\/p>\n

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Pathogens, parasites and commensals<\/h3>\n

Our research unites academic and clinical efforts in a portfolio of world-class infectious diseases research. Our research is responsive to the impacts of local and global infectious disease trends.<\/p>\n

Lead: Professor Richard Grencis<\/p>\n<\/div>\n<\/div>\n

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\"Illustration<\/p>\n

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COVID-19 research<\/h3>\n

Our combined expertise in immunology in the Institute means we\u2019re uniquely placed to understand how COVID-19 behaves and affects individuals.<\/p>\n<\/div>\n<\/div>\n

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Contact Us<\/h4>\n

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+44 (0)161 306 3771<\/a><\/p>\n

 <\/p>\n<\/p>\n

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Find Us<\/h4>\n

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Lydia Becker Institute of Immunology and Inflammation
<\/a>Core Technology Facility\u00a0
46 Grafton Street
M13 9NT<\/a><\/p>\n

\u00a0<\/p>\n

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Connect With Us<\/h4>\n

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