{"id":2555,"date":"2022-09-20T16:06:48","date_gmt":"2022-09-20T15:06:48","guid":{"rendered":"https:\/\/sites.manchester.ac.uk\/lydia-becker-institute-blog\/?page_id=2555"},"modified":"2026-10-06T14:17:44","modified_gmt":"2026-10-06T13:17:44","slug":"barrier-immunology","status":"publish","type":"page","link":"https:\/\/sites.manchester.ac.uk\/lydia-becker-institute\/research\/barrier-immunology\/","title":{"rendered":"Barrier immunology"},"content":{"rendered":"<p>[et_pb_section bb_built=&#8221;1&#8243; admin_label=&#8221;section&#8221; fullwidth=&#8221;on&#8221; next_background_color=&#8221;#000000&#8243; global_module=&#8221;322&#8243;][et_pb_fullwidth_menu global_parent=&#8221;322&#8243; _builder_version=&#8221;3.0.106&#8243; menu_id=&#8221;7&#8243; submenu_direction=&#8221;downwards&#8221; fullwidth_menu=&#8221;off&#8221; background_layout=&#8221;dark&#8221; module_class=&#8221;main-navigation&#8221; \/][\/et_pb_section][et_pb_section bb_built=&#8221;1&#8243; fullwidth=&#8221;off&#8221; specialty=&#8221;off&#8221; transparent_background=&#8221;off&#8221; allow_player_pause=&#8221;off&#8221; inner_shadow=&#8221;off&#8221; parallax=&#8221;off&#8221; parallax_method=&#8221;on&#8221; make_fullwidth=&#8221;off&#8221; use_custom_width=&#8221;off&#8221; width_unit=&#8221;on&#8221; make_equal=&#8221;off&#8221; use_custom_gutter=&#8221;off&#8221; custom_padding=&#8221;0px||0px|&#8221; custom_css_main_element=&#8221;padding-top:0px&#8221; module_class=&#8221;header-image-section&#8221; prev_background_color=&#8221;#ffffff&#8221; next_background_color=&#8221;#ffffff&#8221;][et_pb_row allow_player_pause=&#8221;off&#8221; parallax=&#8221;off&#8221; parallax_method=&#8221;on&#8221; parallax_1=&#8221;off&#8221; parallax_method_1=&#8221;off&#8221; make_fullwidth=&#8221;off&#8221; use_custom_width=&#8221;off&#8221; width_unit=&#8221;on&#8221; use_custom_gutter=&#8221;off&#8221; make_equal=&#8221;off&#8221; custom_margin=&#8221;||0px|&#8221; custom_padding=&#8221;||0px|&#8221; module_class=&#8221;header-image&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; background_size=&#8221;initial&#8221;][et_pb_column type=&#8221;4_4&#8243;][et_pb_image src=&#8221;https:\/\/sites.manchester.ac.uk\/lydia-becker-institute-blog\/wp-content\/uploads\/sites\/69\/2022\/09\/barrier-immunology.jpg&#8221; show_in_lightbox=&#8221;off&#8221; url_new_window=&#8221;off&#8221; use_overlay=&#8221;off&#8221; align=&#8221;left&#8221; always_center_on_mobile=&#8221;on&#8221; use_border_color=&#8221;off&#8221; force_fullwidth=&#8221;off&#8221; custom_margin=&#8221;0px|||&#8221; animation_direction=&#8221;left&#8221; show_bottom_space=&#8221;off&#8221; border_color_all=&#8221;#ffffff&#8221; _builder_version=&#8221;3.17.6&#8243; \/][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section bb_built=&#8221;1&#8243; fullwidth=&#8221;off&#8221; specialty=&#8221;off&#8221; transparent_background=&#8221;off&#8221; allow_player_pause=&#8221;off&#8221; inner_shadow=&#8221;off&#8221; parallax=&#8221;off&#8221; parallax_method=&#8221;on&#8221; make_fullwidth=&#8221;off&#8221; use_custom_width=&#8221;off&#8221; width_unit=&#8221;on&#8221; make_equal=&#8221;off&#8221; use_custom_gutter=&#8221;off&#8221; custom_padding=&#8221;||0px|&#8221; prev_background_color=&#8221;#ffffff&#8221; next_background_color=&#8221;#ffffff&#8221;][et_pb_row allow_player_pause=&#8221;off&#8221; parallax=&#8221;off&#8221; parallax_method=&#8221;on&#8221; parallax_1=&#8221;off&#8221; parallax_method_1=&#8221;off&#8221; make_fullwidth=&#8221;off&#8221; use_custom_width=&#8221;off&#8221; width_unit=&#8221;on&#8221; use_custom_gutter=&#8221;off&#8221; make_equal=&#8221;off&#8221; custom_margin=&#8221;||0px|&#8221; custom_padding=&#8221;||0px|&#8221; module_class=&#8221;breadcrumbs-row&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; background_size=&#8221;initial&#8221;][et_pb_column type=&#8221;4_4&#8243;][et_pb_text admin_label=&#8221;Breadcrumbs (do not remove)&#8221; background_layout=&#8221;light&#8221; text_orientation=&#8221;left&#8221; use_border_color=&#8221;off&#8221; border_color=&#8221;#ffffff&#8221; border_style=&#8221;solid&#8221; module_class=&#8221;breadcrumbs&#8221; custom_css_main_element=&#8221;border-bottom: 1px solid #ececed;&#8221; module_alignment=&#8221;left&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; background_size=&#8221;initial&#8221;]<\/p>\n<span><span><a href=\"https:\/\/sites.manchester.ac.uk\/lydia-becker-institute\/\">Lydia Becker Institute of Immunology and Inflammation<\/a><\/span><\/span>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section bb_built=&#8221;1&#8243; fullwidth=&#8221;off&#8221; specialty=&#8221;on&#8221; transparent_background=&#8221;off&#8221; allow_player_pause=&#8221;off&#8221; inner_shadow=&#8221;off&#8221; parallax=&#8221;off&#8221; parallax_method=&#8221;on&#8221; parallax_1=&#8221;off&#8221; parallax_method_1=&#8221;off&#8221; parallax_2=&#8221;off&#8221; parallax_method_2=&#8221;off&#8221; make_fullwidth=&#8221;off&#8221; use_custom_width=&#8221;off&#8221; width_unit=&#8221;on&#8221; make_equal=&#8221;off&#8221; use_custom_gutter=&#8221;on&#8221; gutter_width=&#8221;2&#8243; prev_background_color=&#8221;#ffffff&#8221; next_background_color=&#8221;#1d1d1d&#8221;][et_pb_column type=&#8221;1_3&#8243;][et_pb_sidebar admin_label=&#8221;Left Nav Sidebar&#8221; area=&#8221;et_pb_widget_area_1&#8243; orientation=&#8221;left&#8221; remove_border=&#8221;on&#8221; background_layout=&#8221;light&#8221; module_id=&#8221;left-nav-menu&#8221; show_border=&#8221;off&#8221; \/][\/et_pb_column][et_pb_column type=&#8221;2_3&#8243; specialty_columns=&#8221;2&#8243;][et_pb_row_inner admin_label=&#8221;Row&#8221;][et_pb_column_inner type=&#8221;4_4&#8243; saved_specialty_column_type=&#8221;2_3&#8243;][et_pb_text admin_label=&#8221;Text: Intro \/ Lung immunology&#8221; _builder_version=&#8221;3.17.6&#8243;]<\/p>\n<h1>Barrier immunology<\/h1>\n<p><iframe loading=\"lazy\" width=\"1080\" height=\"608\" src=\"https:\/\/www.youtube.com\/embed\/-7jK6BzHfnU?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen title=\"Barrier Immunology Branch Introduction\"><\/iframe><\/p>\n<p class=\"subHeading\">Immune cells adapt to the needs of each tissue. Defining the molecular mechanisms influencing immune cell phenotype, function and persistence in health is critical for our understanding of disease and for the development of new medicines to treat them.<\/p>\n<p>The barrier immunology community at The University of Manchester performs fundamental and applied research on every immune cell type in the lung, skin, oral cavity and gastrointestinal tract, taking into account tissue complexity across the life course.<\/p>\n<p>Our research is underpinned by strong clinical collaborators within the NIHR Manchester Biomedical Research Centre\u2019s (BRC) themes relating to cancer, respiratory medicine and dermatology. With access to highly characterised patient cohorts and financial and scientific input from major pharmaceutical companies, we are ideally placed to ask the big questions.<\/p>\n<h2>Lung immunology<\/h2>\n<p><iframe loading=\"lazy\" width=\"1080\" height=\"608\" src=\"https:\/\/www.youtube.com\/embed\/UvjAagOXsrY?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen title=\"Chronic obstructive pulmonary disease (COPD) - Barrier Immunology Case Study\"><\/iframe><\/p>\n<p>Lower respiratory tract infections and chronic obstructive pulmonary disease (COPD) alone account for 8% of global life impairment in 2015, according to the World Health Organisation. We take alternative approaches in this area of significant unmet need by examining:<\/p>\n<ul>\n<li>innate immune interaction with, and regeneration of, epithelium;<\/li>\n<li>immunomatrix, neuroimmunology and cell ultrastructure in health and disease;<\/li>\n<li>molecular mechanisms causing long term perturbations in immune health;<\/li>\n<li>epigenetic remodelling of lung immune cells;<\/li>\n<li>tissue specific training of lung immunity.<\/li>\n<\/ul>\n<p>[\/et_pb_text][et_pb_button admin_label=&#8221;Button: Lung immunology case study&#8221; _builder_version=&#8221;3.17.6&#8243; button_text=&#8221;Lung immunology case study&#8221; button_url=&#8221;\/lydia-becker-institute\/research\/barrier-immunology\/lung-immunology-case-study\/&#8221; \/][et_pb_text admin_label=&#8221;Text: Gastrointestinal immunology&#8221; _builder_version=&#8221;3.17.6&#8243;]<\/p>\n<h2 style=\"padding-top:0.5em\">Gastrointestinal immunology<\/h2>\n<p>Explorative immunology in the gastrointestinal tract has long been a strength at Manchester.<\/p>\n<p>We have a wealth of expertise in pre-clinical in vitro and in vivo models and ex silico analysis. We also collaborate with gastroenterologists at Salford Royal Hospital to explore processes affecting the GI tract in health and disease.<\/p>\n<p>In addition we have well-established links in Africa in order to develop programmes of field and experimental research in the tropics, to enable us to tackle issues such as parasitic infection.<\/p>\n<p>Our breadth of expertise enables collaborative approaches that address key issues including:<\/p>\n<ul>\n<li>the interaction of the epithelium and mucus barrier with the microbiome and pathogens;<\/li>\n<li>the role of the epithelium in educating innate immunity;<\/li>\n<li>mechanisms of macrophage-mediated inflammation and resolution;<\/li>\n<li>mechanisms underpinning regulation and resolution of inflammation (colitis and infection);<\/li>\n<li>parasite biology and vaccine development;<\/li>\n<li>the gut\/body axis in coordinating immune cells to act as a global network to establish appropriate immunity.<\/li>\n<\/ul>\n<p>[\/et_pb_text][et_pb_button admin_label=&#8221;Button: Gastrointestinal immunology case study&#8221; _builder_version=&#8221;3.17.6&#8243; button_text=&#8221;Gastrointestinal immunology case study&#8221; button_url=&#8221;\/lydia-becker-institute\/research\/barrier-immunology\/gastrointestinal-immunology-case-study\/&#8221; \/][et_pb_text admin_label=&#8221;Text: Oral immunology&#8221; _builder_version=&#8221;3.17.6&#8243;]<\/p>\n<h2 style=\"padding-top:0.5em\">Oral immunology<\/h2>\n<p>Periodontitis, severe inflammation of the gingiva and tooth supporting structures, is the most common chronic inflammatory disease in humans.<\/p>\n<p>To understand the mechanisms that safeguard immune homeostasis at this unique barrier we undertake complimentary human and mouse studies to explore:<\/p>\n<ul>\n<li>T cell priming and education at the gingiva;<\/li>\n<li>tissue specific cues shaping oral barrier immune function;<\/li>\n<li>cytokine networks promoting loss of homeostasis;<\/li>\n<li>the systemic consequences of oral inflammation.<\/li>\n<\/ul>\n<p>[\/et_pb_text][et_pb_button admin_label=&#8221;Button: Oral immunology case study&#8221; _builder_version=&#8221;3.17.6&#8243; button_text=&#8221;Oral immunology case study&#8221; button_url=&#8221;\/lydia-becker-institute\/research\/barrier-immunology\/oral-immunology-case-study\/&#8221; \/][et_pb_text admin_label=&#8221;Text: Skin immunology&#8221; _builder_version=&#8221;3.17.6&#8243;]<\/p>\n<h2 style=\"padding-top:0.5em\">Skin immunology<\/h2>\n<p>The skin immune system must be competent at fighting infection and healing wounds whilst being tolerant to harmless substances to prevent inflammatory skin disease. We study aspects of skin health, infection, healing and inflammatory disease, focusing on:<\/p>\n<ul>\n<li>immune cell subsets;<\/li>\n<li>cytokines and soluble mediators of inflammation;<\/li>\n<li>skin specific training;<\/li>\n<li>the resolution of inflammation;<\/li>\n<li>immune mechanisms underlying inflammatory skin diseases;<\/li>\n<li>interactions between microbes and skin.<\/li>\n<\/ul>\n<p>[\/et_pb_text][et_pb_button admin_label=&#8221;Button: Skin immunology case study&#8221; _builder_version=&#8221;3.17.6&#8243; button_text=&#8221;Skin immunology case study&#8221; button_url=&#8221;\/lydia-becker-institute\/research\/barrier-immunology\/skin-immunology-case-study\/&#8221; \/][et_pb_text admin_label=&#8221;Spacing only&#8221; _builder_version=&#8221;3.17.6&#8243;]<\/p>\n<p>\n&nbsp;<\/p>\n<p>[\/et_pb_text][et_pb_divider _builder_version=&#8221;3.17.6&#8243; \/][et_pb_text admin_label=&#8221;Text: People&#8221; _builder_version=&#8221;3.17.6&#8243;]<\/p>\n<h2>People<\/h2>\n<h3>Leads<\/h3>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/joanne.konkel.html\">Dr Joanne Konkel<\/a><\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/sean.knight.html\">Dr Sean Knight<\/a> (Deputy Lead)<\/p>\n<h3 style=\"padding-top: 0.75em;margin-bottom: -0.5em\">Principal investigators<\/h3>\n<p>[\/et_pb_text][et_pb_accordion admin_label=&#8221;Accordion: PIs&#8221; _builder_version=&#8221;3.17.6&#8243;][et_pb_accordion_item _builder_version=&#8221;3.17.6&#8243; title=&#8221;Gastrointestinal&#8221;]<\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/sheena.cruickshank.html\">Professor Sheena Cruickshank<\/a><\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/kathryn.else.html\">Professor Kathryn Else<\/a><\/p>\n<p><a href=\"https:\/\/www.cruk.manchester.ac.uk\/Our-Research\/Cancer-Immunosurveillance\">Dr Evangelos Giampazolias<\/a><\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/john.grainger-2.html\">Dr John Grainger<\/a><\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/matthew.hepworth.html\">Dr Matt Hepworth<\/a><\/p>\n<p><a href=\"https:\/\/research.manchester.ac.uk\/en\/persons\/elizabeth.mann\">Dr Elizabeth Mann<\/a><\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/andrew.mcbain.html\">Professor Andrew McBain<\/a><\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/john.mclaughlin.html\">Professor John McLaughlin<\/a><\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/clare.mills.html\">Professor Clare Mills<\/a><\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/werner.muller.html\">Professor Werner Muller<\/a><\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/william.newman.html\">Professor William Newman<\/a><\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/kathleen.nolan.html\">Dr Kathleen Nolan<\/a><\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/joanne.l.pennock.html\">Dr Joanne Pennock<\/a><\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/i.s.roberts.html\">Professor Ian Roberts<\/a><\/p>\n<p><a href=\"https:\/\/research.manchester.ac.uk\/en\/persons\/mahima-swamy\/\">Professor Mahima Swamy<\/a><\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/dave.thornton.html\">Professor David Thornton<\/a><\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/mark.travis-2.html\">Professor Mark Travis<\/a><\/p>\n<p>[\/et_pb_accordion_item][et_pb_accordion_item _builder_version=&#8221;3.17.6&#8243; title=&#8221;Oral&#8221;]<\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/joanne.konkel.html\">Dr Joanne Konkel<\/a><\/p>\n<p>[\/et_pb_accordion_item][et_pb_accordion_item _builder_version=&#8221;3.17.6&#8243; title=&#8221;Lung&#8221;]<\/p>\n<div class=\"fourcol\">\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/judi.allen.html\">Professor Judi Allen<\/a><\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/cyrill.bussy.html\">Dr Cyrill Bussy<\/a>&nbsp;<\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/en\/researchers\/philip-crosbie(30be2955-b500-43bd-a424-46dbf45f34cf).html\">Dr Phil Crosbie<\/a><\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/daniel.davis.html\">Professor Daniel Davis<\/a><\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/hannah.durrington.html\">Dr Hannah Durrington<\/a><\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/tim.felton.html\">Dr Timothy Felton<\/a><\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/james.fildes.html\">Dr James Fildes<\/a><\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/stephen.fowler.html\">Dr Stephen Fowler<\/a><\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/julie.gibbs.html\">Dr Julie Gibbs<\/a><\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/richard.grencis.html\">Professor Richard Grencis<\/a><\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/sarah.herrick.html\">Dr Sarah Herrick<\/a><\/p>\n<p>Professor Edith Hessel<\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/alexander.horsley.html\">Dr Alex Horsley<\/a><\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/adam.hurlstone.html\">Dr Adam Hurlstone<\/a><\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/tracy.hussell.html\">Professor Tracy Hussell<\/a><\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/andrew.loudon.html\">Professor Andrew Loudon<\/a><\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/andrew.macdonald.html\">Professor Andrew MacDonald<\/a><\/p>\n<p><a href=\"https:\/\/research.manchester.ac.uk\/en\/persons\/madhvi.menon\">Dr Madhvi Menon<\/a><\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/clare.murray.html\">Dr Clare Murray<\/a><\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/nikolaos.papadopoulos.html\">Professor Nikolaos Papadopoulos<\/a><\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/i.s.roberts.html\">Professor Ian Roberts<\/a><\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/angela.simpson.html\">Professor Angela Simpson<\/a><\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/tara.sutherland.html\">Dr Tara Sutherland<\/a><\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/dave.thornton.html\">Professor David Thornton<\/a><\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/jorgen.vestbo.html\">Professor Jorgen Vestbo<\/a><\/p>\n<\/div>\n<p>[\/et_pb_accordion_item][et_pb_accordion_item _builder_version=&#8221;3.17.6&#8243; title=&#8221;Skin&#8221;]<\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/jordi.bella.html\">Dr Jordi Bella<\/a><\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/silvia.bulfone-paus.html\">Professor Silvia Bulfone-Paus<\/a><\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/cyrill.bussy.html\">Dr Cyrill Bussy<\/a><\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/christopher.griffiths.html\">Professor Christopher Griffiths<\/a><\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/anna.nicolaou.html\">Professor Anna Nicolaou<\/a><\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/ralf.paus.html\">Professor Ralf Paus<\/a><\/p>\n<p><a href=\"https:\/\/research.manchester.ac.uk\/en\/persons\/juan-quintana\">Dr Juan Quintana<\/a><\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/lesley.e.rhodes.html\">Professor Lesley Rhodes<\/a><\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/amy.saunders.html\">Dr Amy Saunders<\/a><\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/richard.warren.html\">Professor Richard Warren<\/a><\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/rachel.watson.html\">Professor Rachel Watson<\/a><\/p>\n<p>[\/et_pb_accordion_item][\/et_pb_accordion][\/et_pb_column_inner][\/et_pb_row_inner][\/et_pb_column][\/et_pb_section][et_pb_section bb_built=&#8221;1&#8243; 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Defining the molecular mechanisms influencing immune cell phenotype, function and persistence in health is critical for our understanding of disease and for the development of new medicines to treat them. The barrier immunology community at The University of Manchester performs fundamental and applied [&hellip;]<\/p>\n","protected":false},"author":11,"featured_media":0,"parent":2510,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","_exactmetrics_skip_tracking":false,"footnotes":""},"class_list":["post-2555","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/sites.manchester.ac.uk\/lydia-becker-institute\/wp-json\/wp\/v2\/pages\/2555","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.manchester.ac.uk\/lydia-becker-institute\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sites.manchester.ac.uk\/lydia-becker-institute\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sites.manchester.ac.uk\/lydia-becker-institute\/wp-json\/wp\/v2\/users\/11"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.manchester.ac.uk\/lydia-becker-institute\/wp-json\/wp\/v2\/comments?post=2555"}],"version-history":[{"count":21,"href":"https:\/\/sites.manchester.ac.uk\/lydia-becker-institute\/wp-json\/wp\/v2\/pages\/2555\/revisions"}],"predecessor-version":[{"id":4289,"href":"https:\/\/sites.manchester.ac.uk\/lydia-becker-institute\/wp-json\/wp\/v2\/pages\/2555\/revisions\/4289"}],"up":[{"embeddable":true,"href":"https:\/\/sites.manchester.ac.uk\/lydia-becker-institute\/wp-json\/wp\/v2\/pages\/2510"}],"wp:attachment":[{"href":"https:\/\/sites.manchester.ac.uk\/lydia-becker-institute\/wp-json\/wp\/v2\/media?parent=2555"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}