{"id":2606,"date":"2022-09-21T15:19:09","date_gmt":"2022-09-21T14:19:09","guid":{"rendered":"https:\/\/sites.manchester.ac.uk\/lydia-becker-institute-blog\/?page_id=2606"},"modified":"2024-03-18T11:51:28","modified_gmt":"2024-03-18T11:51:28","slug":"cardiovascular-immunology-and-multi-morbidities","status":"publish","type":"page","link":"https:\/\/sites.manchester.ac.uk\/lydia-becker-institute\/research\/cardiovascular-immunology-and-multi-morbidities\/","title":{"rendered":"Cardiovascular immunology and multi-morbidities"},"content":{"rendered":"<p>[et_pb_section bb_built=&#8221;1&#8243; admin_label=&#8221;section&#8221; fullwidth=&#8221;on&#8221; next_background_color=&#8221;#000000&#8243; global_module=&#8221;322&#8243;][et_pb_fullwidth_menu global_parent=&#8221;322&#8243; _builder_version=&#8221;3.0.106&#8243; menu_id=&#8221;7&#8243; submenu_direction=&#8221;downwards&#8221; fullwidth_menu=&#8221;off&#8221; background_layout=&#8221;dark&#8221; module_class=&#8221;main-navigation&#8221; \/][\/et_pb_section][et_pb_section bb_built=&#8221;1&#8243; fullwidth=&#8221;off&#8221; specialty=&#8221;off&#8221; transparent_background=&#8221;off&#8221; allow_player_pause=&#8221;off&#8221; inner_shadow=&#8221;off&#8221; parallax=&#8221;off&#8221; parallax_method=&#8221;on&#8221; make_fullwidth=&#8221;off&#8221; use_custom_width=&#8221;off&#8221; width_unit=&#8221;on&#8221; make_equal=&#8221;off&#8221; use_custom_gutter=&#8221;off&#8221; custom_padding=&#8221;0px||0px|&#8221; custom_css_main_element=&#8221;padding-top:0px&#8221; module_class=&#8221;header-image-section&#8221; prev_background_color=&#8221;#ffffff&#8221; next_background_color=&#8221;#ffffff&#8221;][et_pb_row allow_player_pause=&#8221;off&#8221; parallax=&#8221;off&#8221; parallax_method=&#8221;on&#8221; parallax_1=&#8221;off&#8221; parallax_method_1=&#8221;off&#8221; make_fullwidth=&#8221;off&#8221; use_custom_width=&#8221;off&#8221; width_unit=&#8221;on&#8221; use_custom_gutter=&#8221;off&#8221; make_equal=&#8221;off&#8221; custom_margin=&#8221;||0px|&#8221; custom_padding=&#8221;||0px|&#8221; module_class=&#8221;header-image&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; background_size=&#8221;initial&#8221;][et_pb_column type=&#8221;4_4&#8243;][et_pb_image src=&#8221;https:\/\/sites.manchester.ac.uk\/lydia-becker-institute-blog\/wp-content\/uploads\/sites\/69\/2022\/09\/cardio-immunology.jpg&#8221; show_in_lightbox=&#8221;off&#8221; url_new_window=&#8221;off&#8221; use_overlay=&#8221;off&#8221; align=&#8221;left&#8221; always_center_on_mobile=&#8221;on&#8221; use_border_color=&#8221;off&#8221; force_fullwidth=&#8221;off&#8221; custom_margin=&#8221;0px|||&#8221; animation_direction=&#8221;left&#8221; show_bottom_space=&#8221;off&#8221; border_color_all=&#8221;#ffffff&#8221; _builder_version=&#8221;3.17.6&#8243; \/][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section bb_built=&#8221;1&#8243; fullwidth=&#8221;off&#8221; specialty=&#8221;off&#8221; transparent_background=&#8221;off&#8221; allow_player_pause=&#8221;off&#8221; inner_shadow=&#8221;off&#8221; parallax=&#8221;off&#8221; parallax_method=&#8221;on&#8221; make_fullwidth=&#8221;off&#8221; use_custom_width=&#8221;off&#8221; width_unit=&#8221;on&#8221; make_equal=&#8221;off&#8221; use_custom_gutter=&#8221;off&#8221; custom_padding=&#8221;||0px|&#8221; prev_background_color=&#8221;#ffffff&#8221; next_background_color=&#8221;#ffffff&#8221;][et_pb_row allow_player_pause=&#8221;off&#8221; parallax=&#8221;off&#8221; parallax_method=&#8221;on&#8221; parallax_1=&#8221;off&#8221; parallax_method_1=&#8221;off&#8221; make_fullwidth=&#8221;off&#8221; use_custom_width=&#8221;off&#8221; width_unit=&#8221;on&#8221; use_custom_gutter=&#8221;off&#8221; make_equal=&#8221;off&#8221; custom_margin=&#8221;||0px|&#8221; custom_padding=&#8221;||0px|&#8221; module_class=&#8221;breadcrumbs-row&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; background_size=&#8221;initial&#8221;][et_pb_column type=&#8221;4_4&#8243;][et_pb_text admin_label=&#8221;Breadcrumbs (do not remove)&#8221; background_layout=&#8221;light&#8221; text_orientation=&#8221;left&#8221; use_border_color=&#8221;off&#8221; border_color=&#8221;#ffffff&#8221; border_style=&#8221;solid&#8221; module_class=&#8221;breadcrumbs&#8221; custom_css_main_element=&#8221;border-bottom: 1px solid #ececed;&#8221; module_alignment=&#8221;left&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; background_size=&#8221;initial&#8221;]<\/p>\n<span><span><a href=\"https:\/\/sites.manchester.ac.uk\/lydia-becker-institute\/\">Lydia Becker Institute of Immunology and Inflammation<\/a><\/span><\/span>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section bb_built=&#8221;1&#8243; fullwidth=&#8221;off&#8221; specialty=&#8221;on&#8221; transparent_background=&#8221;off&#8221; allow_player_pause=&#8221;off&#8221; inner_shadow=&#8221;off&#8221; parallax=&#8221;off&#8221; parallax_method=&#8221;on&#8221; parallax_1=&#8221;off&#8221; parallax_method_1=&#8221;off&#8221; parallax_2=&#8221;off&#8221; parallax_method_2=&#8221;off&#8221; make_fullwidth=&#8221;off&#8221; use_custom_width=&#8221;off&#8221; width_unit=&#8221;on&#8221; make_equal=&#8221;off&#8221; use_custom_gutter=&#8221;on&#8221; gutter_width=&#8221;2&#8243; prev_background_color=&#8221;#ffffff&#8221; next_background_color=&#8221;#1d1d1d&#8221;][et_pb_column type=&#8221;1_3&#8243;][et_pb_sidebar admin_label=&#8221;Left Nav Sidebar&#8221; area=&#8221;et_pb_widget_area_1&#8243; orientation=&#8221;left&#8221; remove_border=&#8221;on&#8221; background_layout=&#8221;light&#8221; module_id=&#8221;left-nav-menu&#8221; show_border=&#8221;off&#8221; \/][\/et_pb_column][et_pb_column type=&#8221;2_3&#8243; specialty_columns=&#8221;2&#8243;][et_pb_row_inner admin_label=&#8221;Row&#8221;][et_pb_column_inner type=&#8221;4_4&#8243; saved_specialty_column_type=&#8221;2_3&#8243;][et_pb_text admin_label=&#8221;Text: Intro&#8221; _builder_version=&#8221;3.17.6&#8243;]<\/p>\n<h1>Cardiovascular immunology and multi-morbidities<\/h1>\n<p><iframe loading=\"lazy\" width=\"1080\" height=\"608\" src=\"https:\/\/www.youtube.com\/embed\/EIQIu9eR0VA?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" allowfullscreen title=\"Cardiovascular Immunology and multi-morbidities Branch Introduction\"><\/iframe><\/p>\n<p class=\"subHeading\">Patients with cardiovascular disease also commonly present with one or more other chronic conditions, known as multi-morbidities. Our researchers are investigating the links between inflammation and these conditions.<\/p>\n<p>Heart failure is highly prevalent in people over 60, the fastest-growing age group worldwide. However, the global epidemic in obesity and type 2 diabetes is changing the demographics who are affected by cardiovascular disease. Multi-morbidities in people with cardiovascular disease make approaches to treatment more complicated and impact on heart failure outcomes.<\/p>\n<p>Inflammation is a common factor in these chronic conditions, yet its role in multi-morbidities and cardiovascular disease is relatively unexplored. A common pathogenic link between chronic diseases is inflammation with patients exhibiting a &#8216;low-grade pro-inflammatory state&#8217;.<\/p>\n<p>It has been known for many years that the innate immune response is linked to the progression of heart failure, with elevated levels of cytokines detected in heart failure patients. However, the inflammatory signalling pathways and contribution to disease trajectory are not fully understood.<\/p>\n<p>Obesity is a chronic inflammatory condition and is an independent risk factor for cardiovascular disease, as well as being a common precursor to type 2 diabetes. It is associated with the development of heart failure with preserved ejection fraction (HFpEF).<\/p>\n<p>Although it is estimated that up to half of all heart failure cases are now due to HPpEF, much less is known about this condition compared to heart failure with reduced ejection fraction (HFrEF), with few treatment options available.<\/p>\n<p>We have ongoing research projects investigating the intersection between inflammation, obesity and heart failure. Specifically, we are looking at the characterisation of structural remodelling of the myocardium and development of mitochondrial dysfunction, and hypertension and the role of perivascular adipose tissue (PVAT).<\/p>\n<p><strong>Read case studies:<\/strong><\/p>\n<p>[\/et_pb_text][et_pb_button admin_label=&#8221;Button: Cardiac mitochondrial dysfunction&#8221; _builder_version=&#8221;3.17.6&#8243; button_text=&#8221;Cardiac mitochondrial dysfunction&#8221; button_url=&#8221;https:\/\/sites.manchester.ac.uk\/lydia-becker-institute\/research\/cardiovascular-immunology-and-multi-morbidities\/inflammation-and-cardiac-mitochondrial-dysfunction-case-study\/&#8221; \/][et_pb_button admin_label=&#8221;Button: Inflammation and hypertension&#8221; _builder_version=&#8221;3.17.6&#8243; button_text=&#8221;Inflammation and hypertension&#8221; button_url=&#8221;https:\/\/sites.manchester.ac.uk\/lydia-becker-institute\/research\/cardiovascular-immunology-and-multi-morbidities\/inflammation-and-hypertension-case-study\/&#8221; \/][et_pb_text admin_label=&#8221;Spacing only&#8221; _builder_version=&#8221;3.17.6&#8243;]<\/p>\n<p>\n&nbsp;<\/p>\n<p>[\/et_pb_text][et_pb_divider _builder_version=&#8221;3.17.6&#8243; \/][et_pb_text admin_label=&#8221;Text: People&#8221; _builder_version=&#8221;3.17.6&#8243;]<\/p>\n<h2>People<\/h2>\n<h3>Leads<\/h3>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/ashraf.kitmitto.html\">Professor Ashraf Kitmitto<\/a><\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/xin.wang.html\">Professor Xin Wang<\/a> (Deputy Lead)<\/p>\n<p><a href=\"https:\/\/research.manchester.ac.uk\/en\/persons\/sophie.saxton\">Dr Sophie Saxton<\/a> (Deputy Lead)<\/p>\n<h3 style=\"padding-top: 1em;margin-bottom: -2em\">Principal investigators<\/h3>\n<p>[\/et_pb_text][\/et_pb_column_inner][\/et_pb_row_inner][et_pb_row_inner admin_label=&#8221;Row&#8221;][et_pb_column_inner type=&#8221;1_2&#8243; saved_specialty_column_type=&#8221;2_3&#8243;][et_pb_text admin_label=&#8221;Text: PIs &#8211; LHS&#8221; _builder_version=&#8221;3.17.6&#8243;]<\/p>\n<div class=\"sixcol\">\n<p><a href=\"https:\/\/research.manchester.ac.uk\/en\/persons\/reza.zadeh\">Dr Reza Aghamohammadzadeh<\/a><\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/david.bechtold.html\">Dr David Bechtold<\/a><\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/tony.heagerty.html\">Professor Anthony Heagerty<\/a><\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/catherine.lawrence.html\">Dr Catherine Lawrence<\/a><\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/anna.nicolaou.html\">Prof Anna Nicolaou<\/a><\/p>\n<\/div>\n<p>[\/et_pb_text][\/et_pb_column_inner][et_pb_column_inner type=&#8221;1_2&#8243; saved_specialty_column_type=&#8221;2_3&#8243;][et_pb_text admin_label=&#8221;Text: PIs &#8211; RHS&#8221; _builder_version=&#8221;3.17.6&#8243;]<\/p>\n<div class=\"sixcol last\">\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/sophie.saxton.html\">Dr Sophie Saxton<\/a><\/p>\n<p><a href=\"https:\/\/www.researchgate.net\/profile\/Handrean-Soran\">Dr Handrean Soran<\/a><\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/andrew.w.trafford.html\">Professor Andrew Trafford<\/a><\/p>\n<p><a href=\"https:\/\/www.salford.ac.uk\/environment-life-sciences\/our-staff\/els-academics\/sarah-withers\">Dr Sarah Withers<\/a> (University of Salford)<\/p>\n<\/div>\n<p>[\/et_pb_text][\/et_pb_column_inner][\/et_pb_row_inner][\/et_pb_column][\/et_pb_section][et_pb_section bb_built=&#8221;1&#8243; admin_label=&#8221;Connect Title&#8221; custom_padding=&#8221;0px||0px|&#8221; _builder_version=&#8221;3.0.90&#8243; background_color=&#8221;#1d1d1d&#8221; module_class=&#8221;footer-section&#8221; prev_background_color=&#8221;#ffffff&#8221; global_module=&#8221;380&#8243;][et_pb_row admin_label=&#8221;row&#8221; global_parent=&#8221;380&#8243; locked=&#8221;off&#8221; allow_player_pause=&#8221;off&#8221; parallax=&#8221;off&#8221; parallax_method=&#8221;on&#8221; parallax_1=&#8221;off&#8221; parallax_method_1=&#8221;off&#8221; parallax_2=&#8221;off&#8221; parallax_method_2=&#8221;off&#8221; parallax_3=&#8221;off&#8221; parallax_method_3=&#8221;off&#8221; make_fullwidth=&#8221;off&#8221; use_custom_width=&#8221;off&#8221; width_unit=&#8221;on&#8221; use_custom_gutter=&#8221;off&#8221; make_equal=&#8221;off&#8221; module_id=&#8221;footer-row&#8221; _builder_version=&#8221;3.0.89&#8243;][et_pb_column type=&#8221;1_3&#8243;][et_pb_text admin_label=&#8221;Contact Us Title&#8221; global_parent=&#8221;380&#8243; background_layout=&#8221;dark&#8221; text_text_color=&#8221;#ffffff&#8221; parent_locked=&#8221;off&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; background_size=&#8221;initial&#8221;]<\/p>\n<h4>Contact Us<\/h4>\n<p>[\/et_pb_text][et_pb_text admin_label=&#8221;Contact Us&#8221; global_parent=&#8221;380&#8243; text_text_color=&#8221;#aaaaaa&#8221; parent_locked=&#8221;off&#8221; background_layout=&#8221;light&#8221; text_orientation=&#8221;left&#8221; use_border_color=&#8221;off&#8221; module_class=&#8221;contact-us&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; background_size=&#8221;initial&#8221; _builder_version=&#8221;3.17.6&#8243;]<\/p>\n<p><a href=\"tel:+441613063771\">+44 (0)161 306 3771<\/a><\/p>\n<p>&nbsp;<\/p>\n<\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_3&#8243;][et_pb_text admin_label=&#8221;Find Us Title&#8221; global_parent=&#8221;380&#8243; background_layout=&#8221;dark&#8221; text_text_color=&#8221;#ffffff&#8221; parent_locked=&#8221;off&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; background_size=&#8221;initial&#8221; _builder_version=&#8221;3.17.6&#8243;]<\/p>\n<h4>Find Us<\/h4>\n<p>[\/et_pb_text][et_pb_text admin_label=&#8221;Address&#8221; global_parent=&#8221;380&#8243; background_layout=&#8221;dark&#8221; text_orientation=&#8221;left&#8221; use_border_color=&#8221;off&#8221; module_id=&#8221;address&#8221; parent_locked=&#8221;off&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; background_size=&#8221;initial&#8221; _builder_version=&#8221;3.17.6&#8243;]<\/p>\n<p><a href=\"http:\/\/www.manchester.ac.uk\/discover\/maps\/interactive-map\/\">Lydia Becker Institute of Immunology and Inflammation<br \/><\/a><a href=\"http:\/\/www.manchester.ac.uk\/discover\/maps\/interactive-map\/\">Core Technology Facility\u00a0<br \/>46 Grafton Street<br \/>M13 9NT<\/a><\/p>\n<p>\u00a0<\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_3&#8243;][et_pb_text admin_label=&#8221;Connect Title&#8221; 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Our researchers are investigating the links between inflammation and these conditions. Heart failure is highly prevalent in people over 60, the fastest-growing age group worldwide. However, the global epidemic in obesity and type [&hellip;]<\/p>\n","protected":false},"author":11,"featured_media":0,"parent":2510,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","_exactmetrics_skip_tracking":false,"footnotes":""},"class_list":["post-2606","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/sites.manchester.ac.uk\/lydia-becker-institute\/wp-json\/wp\/v2\/pages\/2606","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.manchester.ac.uk\/lydia-becker-institute\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sites.manchester.ac.uk\/lydia-becker-institute\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sites.manchester.ac.uk\/lydia-becker-institute\/wp-json\/wp\/v2\/users\/11"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.manchester.ac.uk\/lydia-becker-institute\/wp-json\/wp\/v2\/comments?post=2606"}],"version-history":[{"count":14,"href":"https:\/\/sites.manchester.ac.uk\/lydia-becker-institute\/wp-json\/wp\/v2\/pages\/2606\/revisions"}],"predecessor-version":[{"id":3698,"href":"https:\/\/sites.manchester.ac.uk\/lydia-becker-institute\/wp-json\/wp\/v2\/pages\/2606\/revisions\/3698"}],"up":[{"embeddable":true,"href":"https:\/\/sites.manchester.ac.uk\/lydia-becker-institute\/wp-json\/wp\/v2\/pages\/2510"}],"wp:attachment":[{"href":"https:\/\/sites.manchester.ac.uk\/lydia-becker-institute\/wp-json\/wp\/v2\/media?parent=2606"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}