{"id":2651,"date":"2022-09-22T08:05:11","date_gmt":"2022-09-22T07:05:11","guid":{"rendered":"https:\/\/sites.manchester.ac.uk\/lydia-becker-institute-blog\/?page_id=2651"},"modified":"2026-03-19T07:21:04","modified_gmt":"2026-03-19T07:21:04","slug":"immune-tolerance","status":"publish","type":"page","link":"https:\/\/sites.manchester.ac.uk\/lydia-becker-institute\/research\/immune-tolerance\/","title":{"rendered":"Immune tolerance"},"content":{"rendered":"<p>[et_pb_section bb_built=&#8221;1&#8243; admin_label=&#8221;section&#8221; fullwidth=&#8221;on&#8221; next_background_color=&#8221;#000000&#8243; global_module=&#8221;322&#8243;][et_pb_fullwidth_menu global_parent=&#8221;322&#8243; _builder_version=&#8221;3.0.106&#8243; menu_id=&#8221;7&#8243; submenu_direction=&#8221;downwards&#8221; fullwidth_menu=&#8221;off&#8221; background_layout=&#8221;dark&#8221; module_class=&#8221;main-navigation&#8221; \/][\/et_pb_section][et_pb_section bb_built=&#8221;1&#8243; fullwidth=&#8221;off&#8221; 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background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; background_size=&#8221;initial&#8221;][et_pb_column type=&#8221;4_4&#8243;][et_pb_image src=&#8221;https:\/\/sites.manchester.ac.uk\/lydia-becker-institute-blog\/wp-content\/uploads\/sites\/69\/2022\/09\/immune-tolerance-banner.jpg&#8221; show_in_lightbox=&#8221;off&#8221; url_new_window=&#8221;off&#8221; use_overlay=&#8221;off&#8221; align=&#8221;left&#8221; always_center_on_mobile=&#8221;on&#8221; use_border_color=&#8221;off&#8221; force_fullwidth=&#8221;off&#8221; custom_margin=&#8221;0px|||&#8221; animation_direction=&#8221;left&#8221; show_bottom_space=&#8221;off&#8221; border_color_all=&#8221;#ffffff&#8221; _builder_version=&#8221;3.17.6&#8243; \/][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section bb_built=&#8221;1&#8243; fullwidth=&#8221;off&#8221; specialty=&#8221;off&#8221; transparent_background=&#8221;off&#8221; allow_player_pause=&#8221;off&#8221; inner_shadow=&#8221;off&#8221; parallax=&#8221;off&#8221; parallax_method=&#8221;on&#8221; make_fullwidth=&#8221;off&#8221; use_custom_width=&#8221;off&#8221; width_unit=&#8221;on&#8221; make_equal=&#8221;off&#8221; use_custom_gutter=&#8221;off&#8221; custom_padding=&#8221;||0px|&#8221; prev_background_color=&#8221;#ffffff&#8221; next_background_color=&#8221;#ffffff&#8221;][et_pb_row allow_player_pause=&#8221;off&#8221; parallax=&#8221;off&#8221; parallax_method=&#8221;on&#8221; parallax_1=&#8221;off&#8221; parallax_method_1=&#8221;off&#8221; make_fullwidth=&#8221;off&#8221; use_custom_width=&#8221;off&#8221; width_unit=&#8221;on&#8221; use_custom_gutter=&#8221;off&#8221; make_equal=&#8221;off&#8221; custom_margin=&#8221;||0px|&#8221; custom_padding=&#8221;||0px|&#8221; module_class=&#8221;breadcrumbs-row&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; background_size=&#8221;initial&#8221;][et_pb_column type=&#8221;4_4&#8243;][et_pb_text admin_label=&#8221;Breadcrumbs (do not remove)&#8221; background_layout=&#8221;light&#8221; text_orientation=&#8221;left&#8221; use_border_color=&#8221;off&#8221; border_color=&#8221;#ffffff&#8221; border_style=&#8221;solid&#8221; module_class=&#8221;breadcrumbs&#8221; custom_css_main_element=&#8221;border-bottom: 1px solid #ececed;&#8221; module_alignment=&#8221;left&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; background_size=&#8221;initial&#8221;]<\/p>\n<span><span><a href=\"https:\/\/sites.manchester.ac.uk\/lydia-becker-institute\/\">Lydia Becker Institute of Immunology and Inflammation<\/a><\/span><\/span>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section bb_built=&#8221;1&#8243; fullwidth=&#8221;off&#8221; specialty=&#8221;on&#8221; transparent_background=&#8221;off&#8221; allow_player_pause=&#8221;off&#8221; inner_shadow=&#8221;off&#8221; parallax=&#8221;off&#8221; parallax_method=&#8221;on&#8221; parallax_1=&#8221;off&#8221; parallax_method_1=&#8221;off&#8221; parallax_2=&#8221;off&#8221; parallax_method_2=&#8221;off&#8221; make_fullwidth=&#8221;off&#8221; use_custom_width=&#8221;off&#8221; width_unit=&#8221;on&#8221; make_equal=&#8221;off&#8221; use_custom_gutter=&#8221;on&#8221; gutter_width=&#8221;2&#8243; prev_background_color=&#8221;#ffffff&#8221; next_background_color=&#8221;#1d1d1d&#8221;][et_pb_column type=&#8221;1_3&#8243;][et_pb_sidebar admin_label=&#8221;Left Nav Sidebar&#8221; area=&#8221;et_pb_widget_area_1&#8243; orientation=&#8221;left&#8221; remove_border=&#8221;on&#8221; background_layout=&#8221;light&#8221; module_id=&#8221;left-nav-menu&#8221; show_border=&#8221;off&#8221; \/][\/et_pb_column][et_pb_column type=&#8221;2_3&#8243; specialty_columns=&#8221;2&#8243;][et_pb_row_inner admin_label=&#8221;Row&#8221;][et_pb_column_inner type=&#8221;4_4&#8243; saved_specialty_column_type=&#8221;2_3&#8243;][et_pb_text admin_label=&#8221;Text: Intro&#8221; _builder_version=&#8221;3.17.6&#8243;]<\/p>\n<h1>Immune tolerance<\/h1>\n<p><iframe loading=\"lazy\" width=\"1080\" height=\"608\" src=\"https:\/\/www.youtube.com\/embed\/2KDPPEeMvvg?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen title=\"Immune Tolerance Branch Introduction\"><\/iframe><\/p>\n<p class=\"subHeading\">Our immune system has the difficult task of defending the body against potential threats while recognising and not attacking host molecules or harmless signals from the environment. In autoimmune diseases, this tightly controlled system breaks down and the immune system targets the body\u2019s own organs and tissues.<\/p>\n<p>In some cases, the body may also inappropriately attack beneficial bacteria or harmless allergens. We aim to understand how the immune system is kept under control to keep a state of tolerance.<\/p>\n<p>Autoimmune and chronic inflammaotry diseases are increasingly common with examples include rheumatoid arthritis, psoriatic arthritis, juvenile idiopathic arthritis, psoriasis, myositis, systemic sclerosis, systemic lupus erythematosus and inflammatory bowel disease.<\/p>\n<p>By working closely with basic scientists, immunologists and a variety of clinical disciplines, we aim to increase our understanding of how immune dysregulation causes disease so that scientific discoveries can be translated into the clinic to ultimately improve the management of these conditions.<\/p>\n<p>[\/et_pb_text][et_pb_button admin_label=&#8221;Button: Immune tolerance case study&#8221; _builder_version=&#8221;3.17.6&#8243; button_text=&#8221;Immune tolerance case study&#8221; button_url=&#8221;\/lydia-becker-institute\/research\/immune-tolerance\/immune-tolerance-case-study\/&#8221; \/][et_pb_text admin_label=&#8221;Spacing only&#8221; _builder_version=&#8221;3.17.6&#8243;]<\/p>\n<p>\n&nbsp;<\/p>\n<p>[\/et_pb_text][et_pb_divider _builder_version=&#8221;3.17.6&#8243; \/][et_pb_text admin_label=&#8221;Text: People&#8221; _builder_version=&#8221;3.17.6&#8243;]<\/p>\n<h2>People<\/h2>\n<h3>Lead<\/h3>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/matthew.hepworth.html\">Dr Matthew Hepworth<\/a><\/p>\n<h3 style=\"padding-top: 1em;margin-bottom: -2em\">Principal investigators<\/h3>\n<p>[\/et_pb_text][\/et_pb_column_inner][\/et_pb_row_inner][et_pb_row_inner admin_label=&#8221;Row&#8221;][et_pb_column_inner type=&#8221;1_2&#8243; saved_specialty_column_type=&#8221;2_3&#8243;][et_pb_text admin_label=&#8221;Text: PIs &#8211; LHS&#8221; _builder_version=&#8221;3.17.6&#8243;]<\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/anne.barton.html\">Professor Anne Barton<\/a><\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/nicholas.barnes-2.html\">Dr Nicholas Barnes<\/a><\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/tracy.briggs.html\">Dr Tracy Briggs<\/a><\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/ian.bruce.html\">Professor Ian Bruce<\/a><\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/silvia.bulfone-paus.html\">Professor Silvia Bulfone-Paus<\/a><\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/hector.chinoy.html\">Dr Hector Chinoy<\/a><\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/sheena.cruickshank.html\">Professor Sheena Cruickshank<\/a><\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/giuseppe.dagostino.html\">Dr Giuseppe D\u2019Agostino<\/a><\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/daniel.davis.html\">Professor Daniel Davis<\/a><\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/steve.eyre.html\">Professor Steve Eyre<\/a><\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/james.fildes.html\">Dr James Fildes<\/a><\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/julie.gibbs.html\">Dr Julie Gibbs<\/a><\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/john.grainger-2.html\">Dr John Grainger<\/a><\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/christopher.griffiths.html\">Professor Christopher Griffiths<\/a><\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/ariane.herrick.html\">Professor Ariane Herrick<\/a><\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/en\/researchers\/christine-kleyn(4ca9ae3a-f0c3-4fb2-8687-694ffabcc931).html\">Dr Elise Kleyn<\/a><\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/james.lilleker.html\">Dr James Lilleker<\/a><\/p>\n<p>[\/et_pb_text][\/et_pb_column_inner][et_pb_column_inner type=&#8221;1_2&#8243; saved_specialty_column_type=&#8221;2_3&#8243;][et_pb_text admin_label=&#8221;Text: PIs &#8211; RHS&#8221; _builder_version=&#8221;3.17.6&#8243;]<\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/janine.lamb.html\">Dr Janine Lamb<\/a><\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/clare.mills.html\">Professor Claire Mills<\/a><\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/elizabeth.mann.html\">Dr Elizabeth Mann<\/a><\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/paul.martin-2.html\">Mr Paul Martin<\/a><\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/madhvi.menon.html\">Dr Madhvi Menon<\/a><\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/william.newman.html\">Professor William Newman<\/a><\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/kathleen.nolan.html\">Dr Kathleen Nolan<\/a><\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/gisela.orozco.html\">Dr Gisela Orozco<\/a><\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/ralf.paus.html\">Prof Ralf Paus<\/a><\/p>\n<p><a href=\"https:\/\/research.manchester.ac.uk\/en\/persons\/juan-quintana\">Dr Juan Quintana<\/a><\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/john.reynolds.html\">Dr John Reynolds<\/a><\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/amy.saunders.html\">Dr Amy Saunders<\/a><\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/angela.simpson.html\">Professor Angela Simpson<\/a><\/p>\n<p><a href=\"https:\/\/research.manchester.ac.uk\/en\/persons\/matthew-sinton\">Dr Matthew Sinton<\/a><\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/wendy.thomson.html\">Professor Wendy Thomson<\/a><\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/sebastien.viatte.html\">Dr Sebastien Viatte<\/a><\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/richard.warren.html\">Professor Richard Warren<\/a><\/p>\n<p><a href=\"https:\/\/www.cruk.manchester.ac.uk\/Our-Research\/Leukaemia-Immunology-and-Transplantation\">Dr Mark Williams<\/a><\/p>\n<p><a href=\"https:\/\/research.manchester.ac.uk\/en\/persons\/jonathan.worboys\/\">Dr Jonathan Worboys<\/a><\/p>\n<p>[\/et_pb_text][\/et_pb_column_inner][\/et_pb_row_inner][\/et_pb_column][\/et_pb_section][et_pb_section bb_built=&#8221;1&#8243; 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In autoimmune diseases, this tightly controlled system breaks down and the immune system targets the body\u2019s own organs and tissues. In some cases, the body [&hellip;]<\/p>\n","protected":false},"author":11,"featured_media":0,"parent":2510,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","_exactmetrics_skip_tracking":false,"footnotes":""},"class_list":["post-2651","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/sites.manchester.ac.uk\/lydia-becker-institute\/wp-json\/wp\/v2\/pages\/2651","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.manchester.ac.uk\/lydia-becker-institute\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sites.manchester.ac.uk\/lydia-becker-institute\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sites.manchester.ac.uk\/lydia-becker-institute\/wp-json\/wp\/v2\/users\/11"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.manchester.ac.uk\/lydia-becker-institute\/wp-json\/wp\/v2\/comments?post=2651"}],"version-history":[{"count":19,"href":"https:\/\/sites.manchester.ac.uk\/lydia-becker-institute\/wp-json\/wp\/v2\/pages\/2651\/revisions"}],"predecessor-version":[{"id":4179,"href":"https:\/\/sites.manchester.ac.uk\/lydia-becker-institute\/wp-json\/wp\/v2\/pages\/2651\/revisions\/4179"}],"up":[{"embeddable":true,"href":"https:\/\/sites.manchester.ac.uk\/lydia-becker-institute\/wp-json\/wp\/v2\/pages\/2510"}],"wp:attachment":[{"href":"https:\/\/sites.manchester.ac.uk\/lydia-becker-institute\/wp-json\/wp\/v2\/media?parent=2651"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}