{"id":2664,"date":"2022-09-22T08:19:30","date_gmt":"2022-09-22T07:19:30","guid":{"rendered":"https:\/\/sites.manchester.ac.uk\/lydia-becker-institute-blog\/?page_id=2664"},"modified":"2024-07-30T10:03:43","modified_gmt":"2024-07-30T09:03:43","slug":"immuno-matrix","status":"publish","type":"page","link":"https:\/\/sites.manchester.ac.uk\/lydia-becker-institute\/research\/immuno-matrix\/","title":{"rendered":"Immuno-matrix"},"content":{"rendered":"<p>[et_pb_section bb_built=&#8221;1&#8243; admin_label=&#8221;section&#8221; fullwidth=&#8221;on&#8221; next_background_color=&#8221;#000000&#8243; global_module=&#8221;322&#8243;][et_pb_fullwidth_menu global_parent=&#8221;322&#8243; _builder_version=&#8221;3.0.106&#8243; menu_id=&#8221;7&#8243; submenu_direction=&#8221;downwards&#8221; fullwidth_menu=&#8221;off&#8221; background_layout=&#8221;dark&#8221; module_class=&#8221;main-navigation&#8221; \/][\/et_pb_section][et_pb_section bb_built=&#8221;1&#8243; fullwidth=&#8221;off&#8221; specialty=&#8221;off&#8221; transparent_background=&#8221;off&#8221; allow_player_pause=&#8221;off&#8221; inner_shadow=&#8221;off&#8221; parallax=&#8221;off&#8221; parallax_method=&#8221;on&#8221; make_fullwidth=&#8221;off&#8221; use_custom_width=&#8221;off&#8221; width_unit=&#8221;on&#8221; make_equal=&#8221;off&#8221; use_custom_gutter=&#8221;off&#8221; custom_padding=&#8221;0px||0px|&#8221; custom_css_main_element=&#8221;padding-top:0px&#8221; module_class=&#8221;header-image-section&#8221; prev_background_color=&#8221;#ffffff&#8221; next_background_color=&#8221;#ffffff&#8221;][et_pb_row allow_player_pause=&#8221;off&#8221; parallax=&#8221;off&#8221; parallax_method=&#8221;on&#8221; parallax_1=&#8221;off&#8221; parallax_method_1=&#8221;off&#8221; make_fullwidth=&#8221;off&#8221; use_custom_width=&#8221;off&#8221; width_unit=&#8221;on&#8221; use_custom_gutter=&#8221;off&#8221; make_equal=&#8221;off&#8221; custom_margin=&#8221;||0px|&#8221; custom_padding=&#8221;||0px|&#8221; module_class=&#8221;header-image&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; background_size=&#8221;initial&#8221;][et_pb_column type=&#8221;4_4&#8243;][et_pb_image src=&#8221;https:\/\/sites.manchester.ac.uk\/lydia-becker-institute-blog\/wp-content\/uploads\/sites\/69\/2022\/09\/immuno-matrix-inner-banner.jpg&#8221; show_in_lightbox=&#8221;off&#8221; url_new_window=&#8221;off&#8221; use_overlay=&#8221;off&#8221; align=&#8221;left&#8221; always_center_on_mobile=&#8221;on&#8221; use_border_color=&#8221;off&#8221; force_fullwidth=&#8221;off&#8221; custom_margin=&#8221;0px|||&#8221; animation_direction=&#8221;left&#8221; show_bottom_space=&#8221;off&#8221; border_color_all=&#8221;#ffffff&#8221; _builder_version=&#8221;3.17.6&#8243; \/][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section bb_built=&#8221;1&#8243; fullwidth=&#8221;off&#8221; specialty=&#8221;off&#8221; transparent_background=&#8221;off&#8221; allow_player_pause=&#8221;off&#8221; inner_shadow=&#8221;off&#8221; parallax=&#8221;off&#8221; parallax_method=&#8221;on&#8221; make_fullwidth=&#8221;off&#8221; use_custom_width=&#8221;off&#8221; width_unit=&#8221;on&#8221; make_equal=&#8221;off&#8221; use_custom_gutter=&#8221;off&#8221; custom_padding=&#8221;||0px|&#8221; prev_background_color=&#8221;#ffffff&#8221; next_background_color=&#8221;#ffffff&#8221;][et_pb_row allow_player_pause=&#8221;off&#8221; parallax=&#8221;off&#8221; parallax_method=&#8221;on&#8221; parallax_1=&#8221;off&#8221; parallax_method_1=&#8221;off&#8221; make_fullwidth=&#8221;off&#8221; use_custom_width=&#8221;off&#8221; width_unit=&#8221;on&#8221; use_custom_gutter=&#8221;off&#8221; make_equal=&#8221;off&#8221; custom_margin=&#8221;||0px|&#8221; custom_padding=&#8221;||0px|&#8221; module_class=&#8221;breadcrumbs-row&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; background_size=&#8221;initial&#8221;][et_pb_column type=&#8221;4_4&#8243;][et_pb_text admin_label=&#8221;Breadcrumbs (do not remove)&#8221; background_layout=&#8221;light&#8221; text_orientation=&#8221;left&#8221; use_border_color=&#8221;off&#8221; border_color=&#8221;#ffffff&#8221; border_style=&#8221;solid&#8221; module_class=&#8221;breadcrumbs&#8221; custom_css_main_element=&#8221;border-bottom: 1px solid #ececed;&#8221; module_alignment=&#8221;left&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; background_size=&#8221;initial&#8221;]<\/p>\n<span><span><a href=\"https:\/\/sites.manchester.ac.uk\/lydia-becker-institute\/\">Lydia Becker Institute of Immunology and Inflammation<\/a><\/span><\/span>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section bb_built=&#8221;1&#8243; fullwidth=&#8221;off&#8221; specialty=&#8221;on&#8221; transparent_background=&#8221;off&#8221; allow_player_pause=&#8221;off&#8221; inner_shadow=&#8221;off&#8221; parallax=&#8221;off&#8221; parallax_method=&#8221;on&#8221; parallax_1=&#8221;off&#8221; parallax_method_1=&#8221;off&#8221; parallax_2=&#8221;off&#8221; parallax_method_2=&#8221;off&#8221; make_fullwidth=&#8221;off&#8221; use_custom_width=&#8221;off&#8221; width_unit=&#8221;on&#8221; make_equal=&#8221;off&#8221; use_custom_gutter=&#8221;on&#8221; gutter_width=&#8221;2&#8243; prev_background_color=&#8221;#ffffff&#8221; next_background_color=&#8221;#1d1d1d&#8221;][et_pb_column type=&#8221;1_3&#8243;][et_pb_sidebar admin_label=&#8221;Left Nav Sidebar&#8221; area=&#8221;et_pb_widget_area_1&#8243; orientation=&#8221;left&#8221; remove_border=&#8221;on&#8221; background_layout=&#8221;light&#8221; module_id=&#8221;left-nav-menu&#8221; show_border=&#8221;off&#8221; \/][\/et_pb_column][et_pb_column type=&#8221;2_3&#8243; specialty_columns=&#8221;2&#8243;][et_pb_row_inner admin_label=&#8221;Row&#8221;][et_pb_column_inner type=&#8221;4_4&#8243; saved_specialty_column_type=&#8221;2_3&#8243;][et_pb_text admin_label=&#8221;Text: Intro&#8221; _builder_version=&#8221;3.17.6&#8243;]<\/p>\n<h1>Immuno-matrix<\/h1>\n<p><iframe loading=\"lazy\" width=\"1080\" height=\"608\" src=\"https:\/\/www.youtube.com\/embed\/F8cLjHrhcJ8?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen title=\"Immuno-matrix Branch Introduction\"><\/iframe><\/p>\n<p class=\"subHeading\">Research into matrix is a major strength at Manchester and immuno-matrix is a central theme of the University\u2019s Wellcome Centre for Cell Matrix Research.<\/p>\n<p>Matrix surrounds and supports our cells and accounts for one third of our body mass. Dysregulation of matrix is a central process in the pathogenesis of most human chronic diseases, and a critical factor in fibrosis (scarring). The extracellular matrix regulates and is regulated by the innate and adaptive immune system.<\/p>\n<p>We study how matrix modulates the response of cells to immune signals and thus contributes to host protection. Conversely, we study how immune signals regulate matrix stiffness and turnover, which is essential for the restoration of tissue homeostasis after injury or infection.<\/p>\n<p>Our research is delivering new insights into the interconnectivity between matrix and immune function, with major implications for treatment of chronic diseases and understanding host\u2013pathogen interactions.<\/p>\n<p>[\/et_pb_text][et_pb_button admin_label=&#8221;Button: Immuno-matrix case study&#8221; _builder_version=&#8221;3.17.6&#8243; button_text=&#8221;Immuno-matrix case study&#8221; button_url=&#8221;\/lydia-becker-institute\/research\/immuno-matrix\/immuno-matrix-case-study\/&#8221; \/][et_pb_text admin_label=&#8221;Spacing only&#8221; _builder_version=&#8221;3.17.6&#8243;]<\/p>\n<p>\n&nbsp;<\/p>\n<p>[\/et_pb_text][et_pb_divider _builder_version=&#8221;3.17.6&#8243; \/][et_pb_text admin_label=&#8221;Text: People&#8221; _builder_version=&#8221;3.17.6&#8243;]<\/p>\n<h2>People<\/h2>\n<h3>Leads<\/h3>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/judi.allen.html\">Professor Judi Allen<\/a><\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/dave.thornton.html\">Professor David Thornton<\/a>&nbsp;(Deputy lead)<\/p>\n<h3 style=\"padding-top: 1em;margin-bottom: -2em\">Principal investigators<\/h3>\n<p>[\/et_pb_text][\/et_pb_column_inner][\/et_pb_row_inner][et_pb_row_inner admin_label=&#8221;Row&#8221;][et_pb_column_inner type=&#8221;1_2&#8243; saved_specialty_column_type=&#8221;2_3&#8243;][et_pb_text admin_label=&#8221;Text: PIs &#8211; LHS&#8221; _builder_version=&#8221;3.17.6&#8243;]<\/p>\n<p>\n<a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/jordi.bella.html\">Dr Jordi Bella<\/a><\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/brian.bigger.html\">Dr Brian Bigger<\/a><\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/cyrill.bussy.html\">Dr Cyrill Bussy<\/a><\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/sheena.cruickshank.html\">Professor Sheena Cruickshank<\/a><\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/anthony.day.html\">Professor Tony Day<\/a><\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/douglas.dyer.html\">Dr Douglas Dyer<\/a><\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/kathryn.else.html\">Professor Kathryn Else<\/a><\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/k.g.finegan.html\">Dr Katie Finegan<\/a><\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/richard.grencis.html\">Professor Richard Grencis<\/a><\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/sarah.herrick.html\">Dr Sarah Herrick<\/a><\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/tracy.hussell.html\">Professor Tracy Hussell<\/a><\/p>\n<p>[\/et_pb_text][\/et_pb_column_inner][et_pb_column_inner type=&#8221;1_2&#8243; saved_specialty_column_type=&#8221;2_3&#8243;][et_pb_text admin_label=&#8221;Text: PIs &#8211; RHS&#8221; _builder_version=&#8221;3.17.6&#8243;]<\/p>\n<p>Dr Claus Jorgensen<\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/kimberly.mace.html\">Dr Kimberly Mace<\/a><\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/caroline.milner.html\">Dr Caroline Milner<\/a><\/p>\n<p><a href=\"https:\/\/research.manchester.ac.uk\/en\/persons\/juan-quintana\">Dr Juan Quintana<\/a><\/p>\n<p><a href=\"https:\/\/www.ucm.es\/microbiologia-1\/cell-migration-and-epigenetics\">Dr Javier Redondo-Munoz<\/a> (The University of Madrid)<\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/dominik.ruckerl.html\">Dr Dominik Ruckerl<\/a><\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/angela.simpson.html\">Professor Angela Simpson<\/a><\/p>\n<p><a href=\"https:\/\/research.manchester.ac.uk\/en\/persons\/matthew-sinton\">Dr Matthew Sinton<\/a><\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/tara.sutherland.html\">Dr Tara Sutherland<\/a><\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/dave.thornton.html\">Professor David Thornton<\/a><\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/mark.travis-2.html\">Professor Mark Travis<\/a><\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/jorgen.vestbo.html\">Professor Jorgen Vestbo<\/a><\/p>\n<p>[\/et_pb_text][\/et_pb_column_inner][\/et_pb_row_inner][\/et_pb_column][\/et_pb_section][et_pb_section bb_built=&#8221;1&#8243; admin_label=&#8221;Connect Title&#8221; custom_padding=&#8221;0px||0px|&#8221; _builder_version=&#8221;3.0.90&#8243; background_color=&#8221;#1d1d1d&#8221; module_class=&#8221;footer-section&#8221; prev_background_color=&#8221;#ffffff&#8221; global_module=&#8221;380&#8243;][et_pb_row admin_label=&#8221;row&#8221; global_parent=&#8221;380&#8243; locked=&#8221;off&#8221; allow_player_pause=&#8221;off&#8221; parallax=&#8221;off&#8221; parallax_method=&#8221;on&#8221; parallax_1=&#8221;off&#8221; parallax_method_1=&#8221;off&#8221; parallax_2=&#8221;off&#8221; parallax_method_2=&#8221;off&#8221; parallax_3=&#8221;off&#8221; parallax_method_3=&#8221;off&#8221; make_fullwidth=&#8221;off&#8221; use_custom_width=&#8221;off&#8221; width_unit=&#8221;on&#8221; use_custom_gutter=&#8221;off&#8221; make_equal=&#8221;off&#8221; module_id=&#8221;footer-row&#8221; _builder_version=&#8221;3.0.89&#8243;][et_pb_column type=&#8221;1_3&#8243;][et_pb_text admin_label=&#8221;Contact Us Title&#8221; global_parent=&#8221;380&#8243; background_layout=&#8221;dark&#8221; text_text_color=&#8221;#ffffff&#8221; parent_locked=&#8221;off&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; background_size=&#8221;initial&#8221;]<\/p>\n<h4>Contact Us<\/h4>\n<p>[\/et_pb_text][et_pb_text admin_label=&#8221;Contact Us&#8221; global_parent=&#8221;380&#8243; text_text_color=&#8221;#aaaaaa&#8221; parent_locked=&#8221;off&#8221; background_layout=&#8221;light&#8221; text_orientation=&#8221;left&#8221; use_border_color=&#8221;off&#8221; module_class=&#8221;contact-us&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; background_size=&#8221;initial&#8221; _builder_version=&#8221;3.17.6&#8243;]<\/p>\n<p><a href=\"tel:+441613063771\">+44 (0)161 306 3771<\/a><\/p>\n<p>&nbsp;<\/p>\n<\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_3&#8243;][et_pb_text admin_label=&#8221;Find Us Title&#8221; global_parent=&#8221;380&#8243; background_layout=&#8221;dark&#8221; text_text_color=&#8221;#ffffff&#8221; parent_locked=&#8221;off&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; background_size=&#8221;initial&#8221; _builder_version=&#8221;3.17.6&#8243;]<\/p>\n<h4>Find Us<\/h4>\n<p>[\/et_pb_text][et_pb_text admin_label=&#8221;Address&#8221; global_parent=&#8221;380&#8243; background_layout=&#8221;dark&#8221; text_orientation=&#8221;left&#8221; use_border_color=&#8221;off&#8221; module_id=&#8221;address&#8221; parent_locked=&#8221;off&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; background_size=&#8221;initial&#8221; _builder_version=&#8221;3.17.6&#8243;]<\/p>\n<p><a href=\"http:\/\/www.manchester.ac.uk\/discover\/maps\/interactive-map\/\">Lydia Becker Institute of Immunology and Inflammation<br \/><\/a><a href=\"http:\/\/www.manchester.ac.uk\/discover\/maps\/interactive-map\/\">Core Technology Facility\u00a0<br \/>46 Grafton Street<br \/>M13 9NT<\/a><\/p>\n<p>\u00a0<\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_3&#8243;][et_pb_text admin_label=&#8221;Connect Title&#8221; global_parent=&#8221;380&#8243; background_layout=&#8221;dark&#8221; text_text_color=&#8221;#ffffff&#8221; parent_locked=&#8221;off&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; background_size=&#8221;initial&#8221;]<\/p>\n<h4>Connect With Us<\/h4>\n<p>[\/et_pb_text][et_pb_code admin_label=&#8221;Social Media&#8221; global_parent=&#8221;380&#8243; parent_locked=&#8221;off&#8221; _builder_version=&#8221;3.17.6&#8243;]<\/p>\n<ul class=\"inlineList footer-socialIcons\"><!-- [et_pb_line_break_holder] --> <\/pee>                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        <!-- [et_pb_line_break_holder] --><\/p>\n<li><!-- [et_pb_line_break_holder] --> <a href=\"https:\/\/twitter.com\/LydiaBeckerIII\"><!-- [et_pb_line_break_holder] --> \u00a0<img loading=\"lazy\" decoding=\"async\" src=\"\/\/assets.manchester.ac.uk\/phase1\/templates\/images\/icon-twitter-50.png\" width=\"40\" height=\"40\" alt=\"Twitter page for the Lydia Becker Institute of Immunology and Inflammation\" \/><!-- [et_pb_line_break_holder] --> <\/a><!-- [et_pb_line_break_holder] --> <\/li>\n<p><!-- [et_pb_line_break_holder] --><\/p>\n<li><!-- [et_pb_line_break_holder] --> <a href=\"https:\/\/www.youtube.com\/channel\/UCzBiyW5WlCyTTSQoyxtxRvw\"><!-- [et_pb_line_break_holder] --> \u00a0<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/assets.manchester.ac.uk\/phase1\/templates\/images\/icon-youtube-50.png\" width=\"40\" height=\"40\" alt=\"YouTube page for the Lydia Becker Institute of Immunology and Inflammation\" \/><!-- [et_pb_line_break_holder] --> <\/a><!-- [et_pb_line_break_holder] --> <\/li>\n<p><!-- [et_pb_line_break_holder] --> <\/ul>\n<p><!-- [et_pb_line_break_holder] -->[\/et_pb_code][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p><span><span><a href=\"https:\/\/sites.manchester.ac.uk\/lydia-becker-institute\/\">Lydia Becker Institute of Immunology and Inflammation<\/a><\/span><\/span> Immuno-matrix https:\/\/youtu.be\/F8cLjHrhcJ8 Research into matrix is a major strength at Manchester and immuno-matrix is a central theme of the University\u2019s Wellcome Centre for Cell Matrix Research. Matrix surrounds and supports our cells and accounts for one third of our body mass. Dysregulation of matrix is a central process in the pathogenesis of most human [&hellip;]<\/p>\n","protected":false},"author":11,"featured_media":0,"parent":2510,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","_exactmetrics_skip_tracking":false,"footnotes":""},"class_list":["post-2664","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/sites.manchester.ac.uk\/lydia-becker-institute\/wp-json\/wp\/v2\/pages\/2664","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.manchester.ac.uk\/lydia-becker-institute\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sites.manchester.ac.uk\/lydia-becker-institute\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sites.manchester.ac.uk\/lydia-becker-institute\/wp-json\/wp\/v2\/users\/11"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.manchester.ac.uk\/lydia-becker-institute\/wp-json\/wp\/v2\/comments?post=2664"}],"version-history":[{"count":12,"href":"https:\/\/sites.manchester.ac.uk\/lydia-becker-institute\/wp-json\/wp\/v2\/pages\/2664\/revisions"}],"predecessor-version":[{"id":3814,"href":"https:\/\/sites.manchester.ac.uk\/lydia-becker-institute\/wp-json\/wp\/v2\/pages\/2664\/revisions\/3814"}],"up":[{"embeddable":true,"href":"https:\/\/sites.manchester.ac.uk\/lydia-becker-institute\/wp-json\/wp\/v2\/pages\/2510"}],"wp:attachment":[{"href":"https:\/\/sites.manchester.ac.uk\/lydia-becker-institute\/wp-json\/wp\/v2\/media?parent=2664"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}