{"id":2680,"date":"2022-09-22T09:55:20","date_gmt":"2022-09-22T08:55:20","guid":{"rendered":"https:\/\/sites.manchester.ac.uk\/lydia-becker-institute-blog\/?page_id=2680"},"modified":"2022-09-22T09:55:20","modified_gmt":"2022-09-22T08:55:20","slug":"bacterial-immunology-case-study","status":"publish","type":"page","link":"https:\/\/sites.manchester.ac.uk\/lydia-becker-institute\/research\/pathogens-parasites-and-commensals\/bacterial-immunology-case-study\/","title":{"rendered":"Bacterial immunology case study"},"content":{"rendered":"

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[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section bb_built=”1″ fullwidth=”off” specialty=”on” transparent_background=”off” allow_player_pause=”off” inner_shadow=”off” parallax=”off” parallax_method=”on” parallax_1=”off” parallax_method_1=”off” parallax_2=”off” parallax_method_2=”off” make_fullwidth=”off” use_custom_width=”off” width_unit=”on” make_equal=”off” use_custom_gutter=”on” gutter_width=”2″ prev_background_color=”#ffffff” next_background_color=”#1d1d1d”][et_pb_column type=”1_3″][et_pb_sidebar admin_label=”Left Nav Sidebar” area=”et_pb_widget_area_1″ orientation=”left” remove_border=”on” background_layout=”light” module_id=”left-nav-menu” show_border=”off” \/][\/et_pb_column][et_pb_column type=”2_3″ specialty_columns=”2″][et_pb_row_inner admin_label=”Row”][et_pb_column_inner type=”4_4″ saved_specialty_column_type=”2_3″][et_pb_text _builder_version=”3.17.6″]<\/p>\n

Bacterial immunology<\/h1>\n

New strategies to treat tuberculosis.<\/p>\n

The problem<\/h2>\n

Tuberculosis (TB) is now the most common cause of death from an infectious disease globally.<\/p>\n

In recent years, there has been an unprecedented rise in antibiotic-resistant isolates of the causative pathogen of TB, Mycobacterium tuberculosis. Drug-resistant TB infections are now a major driver of TB-associated mortality.<\/p>\n

Our work<\/h2>\n

To help address this problem, we formed a cross-faculty collaboration involving expertise in microbiology, drug discovery and clinical immunology.<\/p>\n

We have developed novel compounds that prevent intracellular mycobacterial persistence by inhibiting survival factors that are released by Mycobacterium tuberculosis. Testing these compounds in clinical samples is further improving our understanding of the cellular and molecular response to Mycobacterium tuberculosis.
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Principal investigators<\/h2>\n

Professor Lydia Tabernero<\/a><\/p>\n

Dr Jen Cavet<\/a><\/p>\n

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Contact Us<\/h4>\n

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+44 (0) 161 306 6000<\/p>\n

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Find Us<\/h4>\n

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The University of Manchester
Oxford Rd
Manchester
M13 9PL
UK<\/a><\/p>\n

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