{"id":2683,"date":"2022-09-22T10:41:09","date_gmt":"2022-09-22T09:41:09","guid":{"rendered":"https:\/\/sites.manchester.ac.uk\/lydia-becker-institute-blog\/?page_id=2683"},"modified":"2022-09-22T10:41:09","modified_gmt":"2022-09-22T09:41:09","slug":"fungal-biology-case-study","status":"publish","type":"page","link":"https:\/\/sites.manchester.ac.uk\/lydia-becker-institute\/research\/pathogens-parasites-and-commensals\/fungal-biology-case-study\/","title":{"rendered":"Fungal biology case study"},"content":{"rendered":"

[et_pb_section bb_built=”1″ admin_label=”section” fullwidth=”on” next_background_color=”#000000″ global_module=”322″][et_pb_fullwidth_menu global_parent=”322″ _builder_version=”3.0.106″ menu_id=”7″ submenu_direction=”downwards” fullwidth_menu=”off” background_layout=”dark” module_class=”main-navigation” \/][\/et_pb_section][et_pb_section bb_built=”1″ fullwidth=”off” specialty=”off” transparent_background=”off” allow_player_pause=”off” inner_shadow=”off” parallax=”off” parallax_method=”on” make_fullwidth=”off” use_custom_width=”off” width_unit=”on” make_equal=”off” use_custom_gutter=”off” custom_padding=”||0px|” prev_background_color=”#ffffff” next_background_color=”#ffffff”][et_pb_row allow_player_pause=”off” parallax=”off” parallax_method=”on” parallax_1=”off” parallax_method_1=”off” make_fullwidth=”off” use_custom_width=”off” width_unit=”on” use_custom_gutter=”off” make_equal=”off” custom_margin=”||0px|” custom_padding=”||0px|” module_class=”breadcrumbs-row” background_position=”top_left” background_repeat=”repeat” background_size=”initial”][et_pb_column type=”4_4″][et_pb_text admin_label=”Breadcrumbs (do not remove)” background_layout=”light” text_orientation=”left” use_border_color=”off” border_color=”#ffffff” border_style=”solid” module_class=”breadcrumbs” custom_css_main_element=”border-bottom: 1px solid #ececed;” module_alignment=”left” background_position=”top_left” background_repeat=”repeat” background_size=”initial”]<\/p>\nLydia Becker Institute of Immunology and Inflammation<\/a><\/span><\/span>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section bb_built=”1″ fullwidth=”off” specialty=”on” transparent_background=”off” allow_player_pause=”off” inner_shadow=”off” parallax=”off” parallax_method=”on” parallax_1=”off” parallax_method_1=”off” parallax_2=”off” parallax_method_2=”off” make_fullwidth=”off” use_custom_width=”off” width_unit=”on” make_equal=”off” use_custom_gutter=”on” gutter_width=”2″ prev_background_color=”#ffffff” next_background_color=”#1d1d1d”][et_pb_column type=”1_3″][et_pb_sidebar admin_label=”Left Nav Sidebar” area=”et_pb_widget_area_1″ orientation=”left” remove_border=”on” background_layout=”light” module_id=”left-nav-menu” show_border=”off” \/][\/et_pb_column][et_pb_column type=”2_3″ specialty_columns=”2″][et_pb_row_inner admin_label=”Row”][et_pb_column_inner type=”4_4″ saved_specialty_column_type=”2_3″][et_pb_text _builder_version=”3.17.6″]<\/p>\n

Fungal biology case study<\/h1>\n

Antifungal potency of the airway epithelium in health.<\/p>\n

The problem<\/h2>\n

Fungal spores represent a major component of the multitude of noxious inhaled particles continually assaulting human lungs. Our work focuses on the epithelial interactions with inhaled respiratory pathogens, particularly fungal spores and the critical role of these events, especially phagocytosis, in health and disease. Moreover, we wish to understand how these interactions affect communication with other components of human immune and inflammatory cascades underlying disease.<\/p>\n

The work<\/h2>\n

The overall aim is to obtain first-in-field mechanistic insights into curative and dysfunctional epithelial responses following uptake of fungal spores, in particular of the common, yet fatal, environmental mould Aspergillus fumigatus<\/em>.<\/p>\n

To acquire a full mechanistic understanding of fungal-epithelial interactions and how these influence immune responses and are dysregulated in disease, we will:<\/p>\n