{"id":2721,"date":"2022-09-22T14:39:58","date_gmt":"2022-09-22T13:39:58","guid":{"rendered":"https:\/\/sites.manchester.ac.uk\/lydia-becker-institute-blog\/?page_id=2721"},"modified":"2023-10-28T09:09:41","modified_gmt":"2023-10-28T08:09:41","slug":"eco-immunology-and-context-specific-immunology","status":"publish","type":"page","link":"https:\/\/sites.manchester.ac.uk\/lydia-becker-institute\/research\/eco-immunology-and-context-specific-immunology\/","title":{"rendered":"Eco-immunology and context-specific immunology"},"content":{"rendered":"<p>[et_pb_section bb_built=&#8221;1&#8243; admin_label=&#8221;section&#8221; fullwidth=&#8221;on&#8221; next_background_color=&#8221;#000000&#8243; global_module=&#8221;322&#8243;][et_pb_fullwidth_menu global_parent=&#8221;322&#8243; _builder_version=&#8221;3.0.106&#8243; menu_id=&#8221;7&#8243; submenu_direction=&#8221;downwards&#8221; fullwidth_menu=&#8221;off&#8221; background_layout=&#8221;dark&#8221; module_class=&#8221;main-navigation&#8221; \/][\/et_pb_section][et_pb_section bb_built=&#8221;1&#8243; module_class=&#8221;header-image-section&#8221; _builder_version=&#8221;3.0.74&#8243; custom_padding=&#8221;0px||0px|&#8221; custom_css_main_element=&#8221;padding-top:0px&#8221; transparent_background=&#8221;off&#8221; prev_background_color=&#8221;#000000&#8243; next_background_color=&#8221;#000000&#8243;][et_pb_row custom_padding=&#8221;||0px|&#8221; custom_margin=&#8221;||0px|&#8221; parallax_method_1=&#8221;off&#8221; module_class=&#8221;header-image&#8221; _builder_version=&#8221;3.0.47&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221;][et_pb_column type=&#8221;4_4&#8243;][et_pb_image src=&#8221;https:\/\/sites.manchester.ac.uk\/lydia-becker-institute-blog\/wp-content\/uploads\/sites\/69\/2022\/09\/eco-immunology-banner.jpg&#8221; show_bottom_space=&#8221;off&#8221; _builder_version=&#8221;3.17.6&#8243; border_color_all=&#8221;#ffffff&#8221; custom_margin=&#8221;0px|||&#8221; animation_direction=&#8221;left&#8221; use_border_color=&#8221;off&#8221; \/][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section bb_built=&#8221;1&#8243; _builder_version=&#8221;3.0.74&#8243; custom_padding=&#8221;||0px|&#8221; transparent_background=&#8221;off&#8221; prev_background_color=&#8221;#000000&#8243; next_background_color=&#8221;#000000&#8243;][et_pb_row custom_padding=&#8221;||0px|&#8221; custom_margin=&#8221;||0px|&#8221; parallax_method_1=&#8221;off&#8221; module_class=&#8221;breadcrumbs-row&#8221; _builder_version=&#8221;3.0.47&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221;][et_pb_column type=&#8221;4_4&#8243;][et_pb_text admin_label=&#8221;Breadcrumbs (do not remove)&#8221; module_class=&#8221;breadcrumbs&#8221; _builder_version=&#8221;3.0.87&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; module_alignment=&#8221;left&#8221; custom_css_main_element=&#8221;border-bottom: 1px solid #ececed;&#8221; use_border_color=&#8221;off&#8221; border_color=&#8221;#ffffff&#8221; border_style=&#8221;solid&#8221;]<\/p>\n<span><span><a href=\"https:\/\/sites.manchester.ac.uk\/lydia-becker-institute\/\">Lydia Becker Institute of Immunology and Inflammation<\/a><\/span><\/span>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section bb_built=&#8221;1&#8243; use_custom_gutter=&#8221;on&#8221; gutter_width=&#8221;2&#8243; specialty=&#8221;on&#8221; parallax_method_1=&#8221;off&#8221; parallax_method_2=&#8221;off&#8221; _builder_version=&#8221;3.0.74&#8243; transparent_background=&#8221;off&#8221; prev_background_color=&#8221;#000000&#8243; next_background_color=&#8221;#1d1d1d&#8221;][et_pb_column type=&#8221;1_3&#8243;][et_pb_sidebar admin_label=&#8221;Left Nav Sidebar&#8221; area=&#8221;et_pb_widget_area_1&#8243; show_border=&#8221;off&#8221; module_id=&#8221;left-nav-menu&#8221; _builder_version=&#8221;3.0.74&#8243; remove_border=&#8221;on&#8221; \/][\/et_pb_column][et_pb_column type=&#8221;2_3&#8243; specialty_columns=&#8221;2&#8243;][et_pb_row_inner admin_label=&#8221;Row&#8221; _builder_version=&#8221;3.0.47&#8243;][et_pb_column_inner type=&#8221;4_4&#8243; saved_specialty_column_type=&#8221;2_3&#8243;][et_pb_text admin_label=&#8221;Text: Intro&#8221; _builder_version=&#8221;3.17.6&#8243;]<\/p>\n<h1>Eco-immunology and context-specific immunology<\/h1>\n<p><iframe loading=\"lazy\" width=\"1080\" height=\"608\" src=\"https:\/\/www.youtube.com\/embed\/7Crf4yonBE0?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" allowfullscreen title=\"Eco-immunology and Context-specific immunology Branch Introduction\"><\/iframe><\/p>\n<p class=\"subHeading\">How is the immune system shaped and how does it operate in natural settings, as opposed to under the highly controlled laboratory conditions required for mechanistic immunological research?<\/p>\n<p>Our fundamental questions revolve around understanding why immune responses to the same antigenic exposure vary between individuals. One important concept is the idea of the immune trade off. Investing in an immune response comes at a cost.<\/p>\n<p>This cost has to be balanced against other important life events such as growth and reproduction in the face of simultaneous, and varied, extrinsic challenges (for example infections, pollution, changes in diet). Further, this balance will differ between individuals and within an individual over time and space and consequently, the optimal immune response to mount at any one time is highly context dependent.<\/p>\n<p>Understanding the impact of different (and combinations of) variables on how the immune system operates will bring benefits to multiple fields including public health, animal health, wildlife management and conservation.<\/p>\n<p>[\/et_pb_text][et_pb_button admin_label=&#8221;Button: Eco-immunology case study&#8221; button_url=&#8221;\/lydia-becker-institute\/research\/eco-immunology-and-context-specific-immunology\/eco-immunology-case-study\/&#8221; button_text=&#8221;Eco-immunology case study&#8221; _builder_version=&#8221;3.17.6&#8243; \/][et_pb_text admin_label=&#8221;Spacing only&#8221; _builder_version=&#8221;3.17.6&#8243;]<\/p>\n<p>\n&nbsp;<\/p>\n<p>[\/et_pb_text][et_pb_divider _builder_version=&#8221;3.17.6&#8243; \/][et_pb_text admin_label=&#8221;Text: People&#8221; _builder_version=&#8221;3.17.6&#8243;]<\/p>\n<h2>People<\/h2>\n<h3>Leads<\/h3>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/kathryn.else.html\">Professor Kathryn Else<\/a><\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/sheena.cruickshank.html\">Professor Sheena Cruickshank<\/a> (Deputy Lead)<\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/susanne.shultz.html\">Professor Susanne Shultz<\/a> (Deputy Lead)<\/p>\n<h3 style=\"padding-top: 0.65em\">Principal investigators<\/h3>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/judi.allen.html\">Professor Judi Allen<\/a><\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/cyrill.bussy.html\">Dr Cyrill Bussy<\/a><\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/katharine.coyte.html\">Dr Kat Coyte<\/a><\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/richard.grencis.html\">Professor Richard Grencis<\/a><\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/iris.mair.html\">Dr Iris Mair<\/a><\/p>\n<p><a href=\"https:\/\/research.manchester.ac.uk\/en\/persons\/madhvi.menon\">Dr Madhvi Menon<\/a><\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/holly.shiels.html\">Professor Holly Shiels<\/a><\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/dave.thornton.html\">Professor Dave Thornton<\/a><\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/martie.j.van-tongeren.html\">Professor Martie von Tongeren<\/a><\/p>\n<p><a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/catherine.walton.html\">Dr Cathy Walton<\/a><\/p>\n<p>&nbsp;<\/p>\n<p>[\/et_pb_text][\/et_pb_column_inner][\/et_pb_row_inner][\/et_pb_column][\/et_pb_section][et_pb_section bb_built=&#8221;1&#8243; 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text_text_color=&#8221;#ffffff&#8221; parent_locked=&#8221;off&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; background_size=&#8221;initial&#8221; _builder_version=&#8221;3.17.6&#8243;]<\/p>\n<h4>Find Us<\/h4>\n<p>[\/et_pb_text][et_pb_text admin_label=&#8221;Address&#8221; global_parent=&#8221;380&#8243; background_layout=&#8221;dark&#8221; text_orientation=&#8221;left&#8221; use_border_color=&#8221;off&#8221; module_id=&#8221;address&#8221; parent_locked=&#8221;off&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; background_size=&#8221;initial&#8221; _builder_version=&#8221;3.17.6&#8243;]<\/p>\n<p><a href=\"http:\/\/www.manchester.ac.uk\/discover\/maps\/interactive-map\/\">Lydia Becker Institute of Immunology and Inflammation<br \/><\/a><a href=\"http:\/\/www.manchester.ac.uk\/discover\/maps\/interactive-map\/\">Core Technology Facility\u00a0<br \/>46 Grafton Street<br \/>M13 9NT<\/a><\/p>\n<p>\u00a0<\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_3&#8243;][et_pb_text admin_label=&#8221;Connect Title&#8221; 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Our fundamental questions revolve around understanding why immune responses to the same antigenic exposure vary between individuals. One important concept is the [&hellip;]<\/p>\n","protected":false},"author":11,"featured_media":0,"parent":2510,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","_exactmetrics_skip_tracking":false,"footnotes":""},"class_list":["post-2721","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/sites.manchester.ac.uk\/lydia-becker-institute\/wp-json\/wp\/v2\/pages\/2721","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.manchester.ac.uk\/lydia-becker-institute\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sites.manchester.ac.uk\/lydia-becker-institute\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sites.manchester.ac.uk\/lydia-becker-institute\/wp-json\/wp\/v2\/users\/11"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.manchester.ac.uk\/lydia-becker-institute\/wp-json\/wp\/v2\/comments?post=2721"}],"version-history":[{"count":12,"href":"https:\/\/sites.manchester.ac.uk\/lydia-becker-institute\/wp-json\/wp\/v2\/pages\/2721\/revisions"}],"predecessor-version":[{"id":2947,"href":"https:\/\/sites.manchester.ac.uk\/lydia-becker-institute\/wp-json\/wp\/v2\/pages\/2721\/revisions\/2947"}],"up":[{"embeddable":true,"href":"https:\/\/sites.manchester.ac.uk\/lydia-becker-institute\/wp-json\/wp\/v2\/pages\/2510"}],"wp:attachment":[{"href":"https:\/\/sites.manchester.ac.uk\/lydia-becker-institute\/wp-json\/wp\/v2\/media?parent=2721"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}