{"id":3025,"date":"2023-01-23T11:34:02","date_gmt":"2023-01-23T11:34:02","guid":{"rendered":"https:\/\/sites.manchester.ac.uk\/lydia-becker-institute\/?p=3025"},"modified":"2023-01-23T12:04:33","modified_gmt":"2023-01-23T12:04:33","slug":"covid-immunity-debt","status":"publish","type":"post","link":"https:\/\/sites.manchester.ac.uk\/lydia-becker-institute\/2023\/01\/23\/covid-immunity-debt\/","title":{"rendered":"Does COVID really damage your immune system and make you more vulnerable to infections? The evidence is lacking"},"content":{"rendered":"<p>[et_pb_section bb_built=&#8221;1&#8243; admin_label=&#8221;section&#8221; fullwidth=&#8221;on&#8221; next_background_color=&#8221;#000000&#8243; global_module=&#8221;322&#8243;][et_pb_fullwidth_menu global_parent=&#8221;322&#8243; _builder_version=&#8221;3.0.106&#8243; menu_id=&#8221;7&#8243; submenu_direction=&#8221;downwards&#8221; fullwidth_menu=&#8221;off&#8221; background_layout=&#8221;dark&#8221; module_class=&#8221;main-navigation&#8221; \/][\/et_pb_section][et_pb_section bb_built=&#8221;1&#8243; fullwidth=&#8221;off&#8221; specialty=&#8221;on&#8221; prev_background_color=&#8221;#000000&#8243; next_background_color=&#8221;#1d1d1d&#8221;][et_pb_column type=&#8221;2_3&#8243; specialty_columns=&#8221;2&#8243;][et_pb_row_inner locked=&#8221;off&#8221;][et_pb_column_inner type=&#8221;4_4&#8243; saved_specialty_column_type=&#8221;2_3&#8243;][et_pb_post_title _builder_version=&#8221;3.0.106&#8243; title=&#8221;on&#8221; meta=&#8221;on&#8221; author=&#8221;on&#8221; date=&#8221;on&#8221; categories=&#8221;on&#8221; comments=&#8221;on&#8221; featured_image=&#8221;on&#8221; featured_placement=&#8221;above&#8221; text_color=&#8221;dark&#8221; text_background=&#8221;off&#8221; locked=&#8221;on&#8221; parent_locked=&#8221;off&#8221; \/][et_pb_text _builder_version=&#8221;3.17.6&#8243; background_layout=&#8221;light&#8221; parent_locked=&#8221;off&#8221;]<\/p>\n<p>Our <a href=\"https:\/\/sites.manchester.ac.uk\/lydia-becker-institute\/research\/eco-immunology-and-context-specific-immunology\/\">Eco-immunology <\/a>Deputy Branch Lead<a href=\"https:\/\/sites.manchester.ac.uk\/lydia-becker-institute\/research\/eco-immunology-and-context-specific-immunology\/\"> Professor Sheena Cruickshank<\/a> writes in <a href=\"https:\/\/theconversation.com\/does-covid-really-damage-your-immune-system-and-make-you-more-vulnerable-to-infections-the-evidence-is-lacking-197253\">The Conversation<\/a> about the large wave of respiratory tract infections over the past two months in countries like the UK and the US, which has led some to question whether COVID damages the immune system and if measures taken during the pandemic resulted in children &#8220;missing out&#8221; on common childhood infections &#8211; creating an &#8220;immunity debt&#8221;<\/p>\n<p>Professor Cruickshank looks at:<\/p>\n<ul>\n<li>the impact of COVID on our immune system<\/li>\n<li>impact of Long COVID\u00a0<\/li>\n<li>the &#8220;immunity debt&#8221; hypothesis\u00a0<\/li>\n<\/ul>\n<p>On the concept of &#8220;immunity debt&#8221; Professor Cruickshank writes:<\/p>\n<blockquote>\n<p><em>The \u201cimmunity debt\u201d hypothesis suggests the immune system is like a muscle requiring near-constant exposure to infectious agents to keep it functioning. So, the argument goes, a lack of exposure due to lockdowns damaged immune development, especially in children, by making our immune systems \u201cforget\u201d earlier knowledge. This supposedly left them more vulnerable to infections when social mixing returned to normal.<\/em><\/p>\n<p>\u00a0<\/p>\n<p><em>Though this idea has gained traction, there\u2019s no immunological evidence to support it. It\u2019s not true to say we require a constant background of infection for our immune system to work. Our immune systems are immensely robust and powerful. For example, immune memory to the 1918 influenza pandemic was still evident after 90 years.<\/em><\/p>\n<p>\u00a0<\/p>\n<p><em>It\u2019s also not strictly true to say children weren\u2019t exposed to viruses during the early pandemic. Lockdowns didn\u2019t commence until after waves of the usual winter respiratory infections in 2019\/2020, and schools in the UK reopened in autumn 2020 with variable preventive measures, so children were still exposed to infections, including COVID-19.<\/em><\/p>\n<\/blockquote>\n<p>You can read the full article <a href=\"https:\/\/theconversation.com\/does-covid-really-damage-your-immune-system-and-make-you-more-vulnerable-to-infections-the-evidence-is-lacking-197253\">here<\/a><\/p>\n<p>[\/et_pb_text][et_pb_post_nav _builder_version=&#8221;3.0.106&#8243; in_same_term=&#8221;off&#8221; show_prev=&#8221;on&#8221; show_next=&#8221;on&#8221; prev_text=&#8221;Previous&#8221; next_text=&#8221;Next&#8221; locked=&#8221;on&#8221; parent_locked=&#8221;off&#8221; \/][et_pb_comments _builder_version=&#8221;3.0.106&#8243; show_avatar=&#8221;on&#8221; show_reply=&#8221;on&#8221; show_count=&#8221;on&#8221; background_layout=&#8221;light&#8221; header_font_size_tablet=&#8221;51&#8243; header_line_height_tablet=&#8221;2&#8243; 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