Commenting on the award Matthew said “When we get sick, our immune response requires a huge amount of energy to fight off infections. However, at the same time, we typically stop eating and need to rely on our internal energy stores to fuel the immune response, which is a phenomenon that occurs across the animal kingdom. When infections become chronic, this reliance on internal energy stores can lead to tissue wasting (cachexia) which in itself can be fatal.<\/p>\n
During my time as a postdoctoral research associate at the University of Glasgow, we identified that IL-17 is a key driver of adipose tissue wasting during infection with the protozoan parasite Trypanosoma brucei. We also found that IL-17 acts directly on the adipocytes which helps to control the local parasite numbers \u2013 but we don\u2019t know why yet!<\/p>\n
During this fellowship, I\u2019m going to work alongside Dr Juan Quintana<\/a> and Professor Judi Allen<\/a> to understand precisely how IL-17 (and other cytokines) drive changes in adipose tissue mass and immune effector function, and the changes that occur in the adipose-brain communication axis during T. brucei infection. This work has implications for other diseases that cause tissue wasting (e.g. HIV, TB, cancer), as well as for identifying pathways that could be leveraged to treat obesity.<\/p>\n Over the next 5 years, this fellowship will give me the opportunity to train alongside world-leading scientists. Moreover, it is going to provide me with the resources that I need to learn how to build and lead my own research team as I make the transition to independence. I\u2019m very excited to have this opportunity, to continue making contributions to the fields of host-pathogen interactions, immunometabolism, and adipose tissue immunity, and to make my transition to independence at the Lydia Becker Institute.”<\/p>\n \u00a0<\/p>\n [\/et_pb_text][et_pb_post_nav _builder_version=”3.0.106″ in_same_term=”off” show_prev=”on” show_next=”on” prev_text=”Previous” next_text=”Next” locked=”on” parent_locked=”off” \/][et_pb_comments _builder_version=”3.0.106″ show_avatar=”on” show_reply=”on” show_count=”on” background_layout=”light” header_font_size_tablet=”51″ header_line_height_tablet=”2″ custom_button=”on” button_icon_placement=”right” button_text_color=”#ffffff” button_use_icon=”off” locked=”on” parent_locked=”off” button_text_size__hover_enabled=”off” button_text_size__hover=”null” button_one_text_size__hover_enabled=”off” button_one_text_size__hover=”null” button_two_text_size__hover_enabled=”off” button_two_text_size__hover=”null” 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_builder_version=”3.17.6″]<\/p>\n +44 (0)161 306 3771<\/a><\/p>\n <\/p>\n<\/p>\n [\/et_pb_text][\/et_pb_column][et_pb_column type=”1_3″][et_pb_text admin_label=”Find Us Title” global_parent=”380″ background_layout=”dark” text_text_color=”#ffffff” parent_locked=”off” background_position=”top_left” background_repeat=”repeat” background_size=”initial” _builder_version=”3.17.6″]<\/p>\n [\/et_pb_text][et_pb_text admin_label=”Address” global_parent=”380″ background_layout=”dark” text_orientation=”left” use_border_color=”off” module_id=”address” parent_locked=”off” background_position=”top_left” background_repeat=”repeat” background_size=”initial” _builder_version=”3.17.6″]<\/p>\n Lydia Becker Institute of Immunology and Inflammation \u00a0<\/p>\n [\/et_pb_text][\/et_pb_column][et_pb_column type=”1_3″][et_pb_text admin_label=”Connect Title” global_parent=”380″ background_layout=”dark” text_text_color=”#ffffff” parent_locked=”off” background_position=”top_left” background_repeat=”repeat” 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[…]<\/p>\n","protected":false},"author":5220,"featured_media":3777,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","_exactmetrics_skip_tracking":false,"footnotes":""},"categories":[66],"tags":[85,143,124,142],"class_list":["post-3776","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","tag-awards","tag-fellowship","tag-matthew-sinton","tag-wellcome-trust"],"_links":{"self":[{"href":"https:\/\/sites.manchester.ac.uk\/lydia-becker-institute\/wp-json\/wp\/v2\/posts\/3776","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.manchester.ac.uk\/lydia-becker-institute\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sites.manchester.ac.uk\/lydia-becker-institute\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/sites.manchester.ac.uk\/lydia-becker-institute\/wp-json\/wp\/v2\/users\/5220"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.manchester.ac.uk\/lydia-becker-institute\/wp-json\/wp\/v2\/comments?post=3776"}],"version-history":[{"count":7,"href":"https:\/\/sites.manchester.ac.uk\/lydia-becker-institute\/wp-json\/wp\/v2\/posts\/3776\/revisions"}],"predecessor-version":[{"id":3801,"href":"https:\/\/sites.manchester.ac.uk\/lydia-becker-institute\/wp-json\/wp\/v2\/posts\/3776\/revisions\/3801"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/sites.manchester.ac.uk\/lydia-becker-institute\/wp-json\/wp\/v2\/media\/3777"}],"wp:attachment":[{"href":"https:\/\/sites.manchester.ac.uk\/lydia-becker-institute\/wp-json\/wp\/v2\/media?parent=3776"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sites.manchester.ac.uk\/lydia-becker-institute\/wp-json\/wp\/v2\/categories?post=3776"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sites.manchester.ac.uk\/lydia-becker-institute\/wp-json\/wp\/v2\/tags?post=3776"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}Related<\/h1>\n
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How to boost your immune system to avoid colds and coronavirus.<\/h2><\/div><\/div><\/a><\/div>
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