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[\/et_pb_text][et_pb_text admin_label=”Title: Our research” _builder_version=”3.17.6″]<\/p>\n
Our research<\/h2>\n
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We focus on improving the short and long-term outcomes of the critically ill.\u00a0Our vision is to\u00a0establish Manchester as one of the UK’s leading academic centres for critical care research.\u00a0<\/p>\n
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Our purpose is to\u00a0develop a collaborative academic centre of excellence with an international reputation, delivering significant benefits to critically ill patients in Manchester and beyond.<\/p>\n
Our priority areas are:<\/p>\n
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- rapid diagnosis and optimal precision management of infection;<\/li>\n
- optimal management of acute and chronic respiratory failure;<\/li>\n
- optimal management of tracheostomy and the airway;<\/li>\n
- preparation, perioperative management and rehabilitation of high-risk surgical patients who require critical care.<\/li>\n<\/ul>\n
[\/et_pb_text][et_pb_accordion admin_label=”Accordion: Research” _builder_version=”3.17.6″][et_pb_accordion_item _builder_version=”3.17.6″ title=”Precision diagnostics”]<\/p>\n
Infection and sepsis are the biggest killers in the critically ill. Patients are vulnerable to common and opportunistic infections and rapid, accurate diagnosis of infection is vital when time is short.<\/p>\n
Critical illness and its treatment can change the physiology of the body significantly, meaning that conventional therapies have to be adapted to be effective when patients have organ failures, fluid overload or extra-corporeal support such as dialysis or extracorporeal membrane oxygenation (ECMO).<\/p>\n
What we do<\/h3>\n
MACC researchers deliver cutting edge research at the bedside and lead on national strategies to detect infection faster than ever before, and to tailor our therapies to be maximally effective and minimise antibiotic resistance.<\/p>\n
We have led on developing bedside blood tests to rapidly detect bacteria and identify maximally effective antibiotics, both in the blood and exhaled breath.<\/p>\n
Our work has led to major collaborations and funding to develop new labs, techniques and technologies to detect and treat infection with precision right here in Manchester.<\/p>\n
Examples of our work include:<\/p>\n
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- Accuracy of LightCycler SeptiFast for the detection and identification of pathogens in the blood of patients with suspected sepsis: a systematic review and meta-analysis<\/a><\/li>\n
- Individualised antibiotic dosing for patients who are critically ill: challenges and potential solutions<\/span><\/a><\/li>\n<\/ul>\n
[\/et_pb_accordion_item][et_pb_accordion_item _builder_version=”3.17.6″ title=”Acute respiratory failure”]<\/p>\n
Critical illness is commonly associated with respiratory failure, where the body’s ability to take in oxygen and exhale carbon dioxide is overwhelmed.<\/p>\n
Simple strategies such as delivering increasing concentrations of oxygen aren’t always enough, and in critical care patients, we often have to supplement additional oxygen therapy with invasive or non-invasive pressure support to help breathing.<\/p>\n
Conventional strategies involve intubation of the trachea and mechanical ventilation, but ventilation of inflamed lungs can cause its own problems, leading to (worsening of) acute lung injury.<\/p>\n
What we do<\/h3>\n
We are involved in trials to help patients who develop acute respiratory failure. These trials involve:<\/p>\n
- \n
- developing and testing rapid infection diagnostics in blood or exhaled breath to promptly detect infection;<\/li>\n
- tailoring antibiotic therapies in the critically ill to ensure adequate levels of antibiotics in the right tissues when organ failures complicate treatment;<\/li>\n
- strategies to reduce the requirements for patients to need mechanical ventilation, including extra-corporeal oxygenation (ECMO) and CO2 removal;<\/li>\n
- strategies to reduce the amount of ventilation that patients require, including extra-corporeal oxygenation and CO2 removal, allowing us to be more gentle to the lungs;<\/li>\n
- immune therapies and stem cell therapies to reduce inflammation in acute lung injury.<\/li>\n<\/ul>\n
[\/et_pb_accordion_item][et_pb_accordion_item _builder_version=”3.17.6″ title=”Improving tracheostomy care” link_option_url=”www.tracheostomy.org.uk”]<\/p>\n
Between 10% and 15% of all ICU admissions will require a tracheostomy. This artificial airway can be lifesaving, but it can also cause serious problems if the tube becomes blocked or displaced.<\/p>\n
Patients tell us that the worst thing about having a tracheostomy is not being able to speak, eat or drink properly, especially when recovering from critical illness.<\/p>\n
What we do<\/h3>\n
Tracheostomy care is a great example of the multidisciplinary team working together, and MACC collaborates widely with research-active colleagues in related specialities, with strong representation from nursing, physiotherapy and speech and language therapy.<\/p>\n
We also pride ourselves on having patients and their families embedded at the core of what we do.<\/p>\n
MACC has attracted significant funding to research the problems with tracheostomies, develop solutions and resources to improve care, and develop new technologies to improve communication.<\/p>\n
Examples of our work can be seen on the National Tracheostomy Safety Project website<\/a> and the Global Tracheostomy Collaborative website<\/a>. You can also watch a video from the National Tracheostomy Safety Project<\/a>.<\/p>\n
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The Enhanced Recovery After Surgery Plus (ERAS+) is a programme to help patients prepare for major surgery. The program has been designed by senior NHS health care professionals and uses cutting edge technology to prepare patients for surgery and help them recover. ERAS+ has been pioneered in Greater Manchester, linking with experts and programs across the UK.<\/p>\n
You can find out more about our work here: www.erasplus.co.uk<\/a><\/p>\n
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Support for trainees<\/h2>\n
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We support trainees in our region who are interested in research into critical illness, typically from anaesthesia, critical care medicine, respiratory or acute medical backgrounds.<\/p>\n
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Trainee doctors and students can collaborate with us for short projects during relevant placements or join us for more substantial placements as part of formal research attachments. We accept doctors for formal academic training, including Academic Foundation posts, Academic Clinical Fellow posts, Masters and Doctoral training. Some of our training posts are part of formal academic training pathways.<\/p>\n
[\/et_pb_text][et_pb_button admin_label=”Button: Case studies” _builder_version=”3.17.6″ button_text=”View case studies” button_url=”\/macc\/case-studies\/” \/][et_pb_text admin_label=”Text: Support for trainees – RHS – after button” _builder_version=”3.17.6″]<\/p>\n
We welcome FY, ACCS and ST trainees at junior and senior level. We also have projects for Clinical Fellows from a variety of backgrounds. We train and supervise academic staff from a wide variety of nursing, medical and allied healthcare roles, including formal Masters and PhD projects.<\/p>\n
We can offer experience and guidance in all aspects of research, including:<\/p>\n
- \n
- Study delivery, recruitment, data collection, synthesis and analysis<\/li>\n
- Publication and Presentation (regional, national and international)<\/li>\n
- Study setup and design<\/li>\n
- Negotiations with potential funders and industry<\/li>\n
- Grant applications<\/li>\n
- Research Ethics Committee (REC)<\/li>\n
- Health Research Authority (HRA) approvals<\/li>\n<\/ul>\n
We encourage and support our trainees to present work at local, national and international meetings and to publish in high profile journals.<\/p>\n
Placements that are three, six or 12 months long are available, and funded Masters and PhD opportunities are available (depending on funding). We are supported by Health Education England North West<\/a> in providing specific research modules for trainees.<\/p>\n
We encourage trainees to consider formal higher degrees, typically MPhil or MRes programmes at The University of Manchester. This will require out-of-programme approval from your base speciality heads of school, but we have found schools to be extremely supportive of our research programmes for trainees.<\/p>\n
We can typically offer research clinical fellowship posts on our ICUs to support you during out-of-programme research placements.<\/p>\n
To find out more, contact us by emailing\u00a0macc@manchester.ac.uk<\/a>.<\/p>\n
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[\/et_pb_text][et_pb_text admin_label=”Title: Collaborate with us” _builder_version=”3.17.6″]<\/p>\n
Collaborate with us<\/h2>\n
[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row][et_pb_column type=”1_2″][et_pb_text admin_label=”Text: Collaborate – LHS” _builder_version=”3.17.6″]<\/p>\n
Our researchers hold a balanced portfolio of commercially funded research, grant-funded projects and NIHR portfolio studies.<\/p>\n
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We have attracted grant income of over \u00a317 million since 2012, funding a diverse portfolio from lab-based research through to bedside clinical research, hypothesis testing, data synthesis and analysis, implementation science and quality improvements.<\/p>\n
We welcome collaborations with other organisations locally, nationally and around the world. We have successfully collaborated with industry in the fields of infection diagnostics, optimal antimicrobial therapies, invasive ventilation and airway management.<\/p>\n
To find out more, contact us by emailing\u00a0macc@manchester.ac.uk<\/a>.<\/p>\n
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[\/et_pb_text][et_pb_text admin_label=”Title: Contact us” _builder_version=”3.17.6″]<\/p>\n
Contact us<\/h2>\n
[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row][et_pb_column type=”1_2″][et_pb_text admin_label=”Text: Contact – LHS” _builder_version=”3.17.6″]<\/p>\n
We are happy to hear from trainees who are interested in our placements, as well as from potential research collaborators.<\/p>\n
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You can get in touch with MACC by emailing\u00a0macc@manchester.ac.uk.<\/a><\/p>\n
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Contact Us<\/h4>\n
[\/et_pb_text][et_pb_text admin_label=”Contact Us” global_parent=”380″ text_text_color=”#aaaaaa” parent_locked=”off” background_layout=”light” text_orientation=”left” use_border_color=”off” border_color=”#ffffff” border_style=”solid” module_class=”contact-us” background_position=”top_left” background_repeat=”repeat” background_size=”initial”]<\/p>\n
+44 (0) 161 306 6000<\/p>\n
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Find Us<\/h4>\n
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The University of Manchester
Oxford Rd
Manchester
M13 9PL
UK<\/a><\/p>\n[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_3″][et_pb_text admin_label=”Connect Title” global_parent=”380″ background_layout=”dark” text_text_color=”#ffffff” parent_locked=”off” background_position=”top_left” background_repeat=”repeat” background_size=”initial”]<\/p>\n
Connect With Us<\/h4>\n
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[\/et_pb_code][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"
Conducting high-quality research in the critically ill.
\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t<\/div> Manchester Academic Critical Care (MACC)\u00a0is a collaboration between The University of Manchester’s teaching hospitals. Our research focuses on data synthesis and hypothesis testing in the critically ill. We develop research skills in local researchers and trainees through placements on our projects. We conduct novel and […]<\/p>\n","protected":false},"author":4,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","_exactmetrics_skip_tracking":false,"footnotes":""},"class_list":["post-1420","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/sites.manchester.ac.uk\/macc\/wp-json\/wp\/v2\/pages\/1420","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.manchester.ac.uk\/macc\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sites.manchester.ac.uk\/macc\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sites.manchester.ac.uk\/macc\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.manchester.ac.uk\/macc\/wp-json\/wp\/v2\/comments?post=1420"}],"version-history":[{"count":38,"href":"https:\/\/sites.manchester.ac.uk\/macc\/wp-json\/wp\/v2\/pages\/1420\/revisions"}],"predecessor-version":[{"id":1676,"href":"https:\/\/sites.manchester.ac.uk\/macc\/wp-json\/wp\/v2\/pages\/1420\/revisions\/1676"}],"wp:attachment":[{"href":"https:\/\/sites.manchester.ac.uk\/macc\/wp-json\/wp\/v2\/media?parent=1420"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
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- Individualised antibiotic dosing for patients who are critically ill: challenges and potential solutions<\/span><\/a><\/li>\n<\/ul>\n
- Accuracy of LightCycler SeptiFast for the detection and identification of pathogens in the blood of patients with suspected sepsis: a systematic review and meta-analysis<\/a><\/li>\n