{"id":1423,"date":"2021-02-01T14:53:04","date_gmt":"2021-02-01T14:53:04","guid":{"rendered":"https:\/\/sites.manchester.ac.uk\/masterplans\/?page_id=1423"},"modified":"2021-02-25T10:57:54","modified_gmt":"2021-02-25T10:57:54","slug":"home","status":"publish","type":"page","link":"https:\/\/sites.manchester.ac.uk\/masterplans\/","title":{"rendered":"Home"},"content":{"rendered":"<p>[et_pb_section bb_built=&#8221;1&#8243; admin_label=&#8221;section&#8221; fullwidth=&#8221;on&#8221; next_background_color=&#8221;#000000&#8243; global_module=&#8221;322&#8243;][et_pb_fullwidth_menu global_parent=&#8221;322&#8243; _builder_version=&#8221;3.0.106&#8243; menu_id=&#8221;7&#8243; submenu_direction=&#8221;downwards&#8221; fullwidth_menu=&#8221;off&#8221; background_layout=&#8221;dark&#8221; module_class=&#8221;main-navigation&#8221; \/][\/et_pb_section][et_pb_section bb_built=&#8221;1&#8243; fullwidth=&#8221;on&#8221; specialty=&#8221;off&#8221; prev_background_color=&#8221;#000000&#8243; next_background_color=&#8221;#000000&#8243;][et_pb_fullwidth_slider show_arrows=&#8221;off&#8221; 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button_one_letter_spacing__hover=&#8221;null&#8221; button_two_letter_spacing__hover_enabled=&#8221;off&#8221; button_two_letter_spacing__hover=&#8221;null&#8221; button_bg_color__hover_enabled=&#8221;off&#8221; button_bg_color__hover=&#8221;null&#8221; button_one_bg_color__hover_enabled=&#8221;off&#8221; button_one_bg_color__hover=&#8221;null&#8221; button_two_bg_color__hover_enabled=&#8221;off&#8221; button_two_bg_color__hover=&#8221;null&#8221; _builder_version=&#8221;3.17.6&#8243;][et_pb_slide _builder_version=&#8221;3.17.6&#8243; heading=&#8221;MASTERPLANS&#8221; button_link=&#8221;#&#8221; url_new_window=&#8221;off&#8221; link_option_url_new_window=&#8221;off&#8221; background_color=&#8221;#ffffff&#8221; use_background_color_gradient=&#8221;off&#8221; background_color_gradient_start=&#8221;#2b87da&#8221; background_color_gradient_end=&#8221;#29c4a9&#8243; background_color_gradient_type=&#8221;linear&#8221; background_color_gradient_direction=&#8221;180deg&#8221; background_color_gradient_direction_radial=&#8221;center&#8221; background_color_gradient_start_position=&#8221;0%&#8221; background_color_gradient_end_position=&#8221;100%&#8221; background_color_gradient_overlays_image=&#8221;off&#8221; background_image=&#8221;https:\/\/sites.manchester.ac.uk\/masterplans\/wp-content\/uploads\/sites\/288\/2021\/02\/lupus-butterflies-banner.jpg&#8221; parallax=&#8221;off&#8221; parallax_method=&#8221;on&#8221; background_size=&#8221;cover&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;no-repeat&#8221; background_blend=&#8221;normal&#8221; allow_player_pause=&#8221;off&#8221; background_video_pause_outside_viewport=&#8221;on&#8221; use_bg_overlay=&#8221;off&#8221; use_text_overlay=&#8221;off&#8221; text_border_radius=&#8221;3&#8243; alignment=&#8221;center&#8221; child_filter_hue_rotate=&#8221;0deg&#8221; child_filter_saturate=&#8221;100%&#8221; child_filter_brightness=&#8221;100%&#8221; child_filter_contrast=&#8221;100%&#8221; child_filter_invert=&#8221;0%&#8221; child_filter_sepia=&#8221;0%&#8221; child_filter_opacity=&#8221;100%&#8221; child_filter_blur=&#8221;0px&#8221; child_mix_blend_mode=&#8221;normal&#8221; background_layout=&#8221;dark&#8221; text_shadow_style=&#8221;none&#8221; header_text_shadow_style=&#8221;none&#8221; body_text_shadow_style=&#8221;none&#8221; custom_button=&#8221;on&#8221; button_bg_color=&#8221;#27a2db&#8221; button_bg_use_color_gradient=&#8221;off&#8221; button_bg_color_gradient_overlays_image=&#8221;off&#8221; button_border_color=&#8221;#27a2db&#8221; button_use_icon=&#8221;on&#8221; button_on_hover=&#8221;on&#8221; button_text_shadow_style=&#8221;none&#8221; box_shadow_style_button=&#8221;none&#8221; hover_transition_duration=&#8221;300ms&#8221; hover_transition_delay=&#8221;0ms&#8221; hover_transition_speed_curve=&#8221;ease&#8221; text_shadow_horizontal_length=&#8221;0em&#8221; text_shadow_vertical_length=&#8221;0em&#8221; text_shadow_blur_strength=&#8221;0em&#8221; header_text_shadow_horizontal_length=&#8221;0em&#8221; header_text_shadow_vertical_length=&#8221;0em&#8221; header_text_shadow_blur_strength=&#8221;0em&#8221; body_text_shadow_horizontal_length=&#8221;0em&#8221; body_text_shadow_vertical_length=&#8221;0em&#8221; body_text_shadow_blur_strength=&#8221;0em&#8221; button_text_shadow_horizontal_length=&#8221;0em&#8221; button_text_shadow_vertical_length=&#8221;0em&#8221; button_text_shadow_blur_strength=&#8221;0em&#8221;]<\/p>\n<p>MAximizing Sle ThERapeutic PotentiaL by Application of Novel and Stratified approaches<\/p>\n<p>[\/et_pb_slide][\/et_pb_fullwidth_slider][\/et_pb_section][et_pb_section bb_built=&#8221;1&#8243; fullwidth=&#8221;off&#8221; specialty=&#8221;off&#8221; prev_background_color=&#8221;#000000&#8243; next_background_color=&#8221;#1d1d1d&#8221;][et_pb_row allow_player_pause=&#8221;off&#8221; parallax=&#8221;off&#8221; parallax_method=&#8221;on&#8221; parallax_1=&#8221;off&#8221; parallax_method_1=&#8221;off&#8221; make_fullwidth=&#8221;off&#8221; use_custom_width=&#8221;off&#8221; width_unit=&#8221;on&#8221; use_custom_gutter=&#8221;off&#8221; make_equal=&#8221;off&#8221; custom_padding=&#8221;3em||0.5em|&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; background_size=&#8221;initial&#8221;][et_pb_column type=&#8221;4_4&#8243;][et_pb_text admin_label=&#8221;Spacing only&#8221; _builder_version=&#8221;3.17.6&#8243;]<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row][et_pb_column type=&#8221;1_2&#8243;][et_pb_text admin_label=&#8221;Text: Intro &#8211; LHS&#8221; _builder_version=&#8221;3.17.6&#8243;]<\/p>\n<p class=\"subHeading\" id=\"intro\" style=\"color: #14516e\">Identifying predictors of response to drugs in systemic lupus erythematosus (SLE) patients.<\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_2&#8243;][et_pb_text admin_label=&#8221;Text: Intro &#8211; RHS&#8221; _builder_version=&#8221;3.17.6&#8243;]<\/p>\n<p>\nThe MASTERPLANS project (2015-2021), led by <a href=\"https:\/\/www.research.manchester.ac.uk\/portal\/ian.bruce.html\">Professor Ian Bruce<\/a>, identified groups of patients that respond well or less well to particular drugs.<\/p>\n<p>We analysed a range of datasets and biological samples and brought information from many sources together to produce formulae (algorithms) that can predict response better than in current standard of care.<\/p>\n<p>Following future research to validate our results, the ultimate aim is that care for SLE patients can be improved by putting them on the right drug, sooner.<\/p>\n<p>[\/et_pb_text][et_pb_divider _builder_version=&#8221;3.17.6&#8243; \/][et_pb_text admin_label=&#8221;Text: Jump links&#8221; _builder_version=&#8221;3.17.6&#8243;]<\/p>\n<p style=\"margin-top: -1em\"><strong>On this page:<\/strong><\/p>\n<ul>\n<li><a href=\"#papers\">Our findings<\/a><\/li>\n<li><a href=\"#ppi\">Patient and public involvement<\/a><\/li>\n<li><a href=\"#collaborators\">Partners and collaborators<\/a><\/li>\n<li><a href=\"#contact\">Contact us<\/a><\/li>\n<\/ul>\n<p>[\/et_pb_text][et_pb_text admin_label=&#8221;Spacing only&#8221; _builder_version=&#8221;3.17.6&#8243;]<\/p>\n<p>&nbsp;<\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row][et_pb_column type=&#8221;1_3&#8243;][et_pb_cta admin_label=&#8221;Content Box: Funding&#8221; url_new_window=&#8221;off&#8221; use_background_color=&#8221;on&#8221; background_color=&#8221;#7EBEC5&#8243; background_layout=&#8221;dark&#8221; text_orientation=&#8221;left&#8221; use_border_color=&#8221;off&#8221; border_color=&#8221;#ffffff&#8221; border_style=&#8221;solid&#8221; custom_button=&#8221;off&#8221; button_letter_spacing=&#8221;0&#8243; button_use_icon=&#8221;default&#8221; button_icon_placement=&#8221;right&#8221; button_on_hover=&#8221;on&#8221; button_letter_spacing_hover=&#8221;0&#8243; module_class=&#8221;content_box content_box_dark_bg&#8221; _builder_version=&#8221;3.17.6&#8243;]<\/p>\n<p style=\"text-align: center;font-size: 2em\">\u00a3 4.6m+<\/p>\n<p style=\"text-align: center\">Funded by the Medical Research Council and LUPUS UK<\/p>\n<p>[\/et_pb_cta][\/et_pb_column][et_pb_column type=&#8221;1_3&#8243;][et_pb_cta admin_label=&#8221;Content Box: Algorithms&#8221; url_new_window=&#8221;off&#8221; use_background_color=&#8221;on&#8221; background_color=&#8221;#7EBEC5&#8243; background_layout=&#8221;dark&#8221; text_orientation=&#8221;left&#8221; use_border_color=&#8221;off&#8221; border_color=&#8221;#ffffff&#8221; border_style=&#8221;solid&#8221; custom_button=&#8221;off&#8221; button_letter_spacing=&#8221;0&#8243; button_use_icon=&#8221;default&#8221; button_icon_placement=&#8221;right&#8221; button_on_hover=&#8221;on&#8221; button_letter_spacing_hover=&#8221;0&#8243; module_class=&#8221;content_box content_box_dark_bg&#8221; _builder_version=&#8221;3.17.6&#8243;]<\/p>\n<p style=\"text-align: center;font-size: 2em\">3<\/p>\n<p style=\"text-align: center\">Algorithms predicting response to rituximab, belimumab and mycophenolate<\/p>\n<p>[\/et_pb_cta][\/et_pb_column][et_pb_column type=&#8221;1_3&#8243;][et_pb_cta admin_label=&#8221;Content Box: Sub-projects&#8221; url_new_window=&#8221;off&#8221; use_background_color=&#8221;on&#8221; background_color=&#8221;#7EBEC5&#8243; background_layout=&#8221;dark&#8221; text_orientation=&#8221;left&#8221; use_border_color=&#8221;off&#8221; border_color=&#8221;#ffffff&#8221; border_style=&#8221;solid&#8221; custom_button=&#8221;off&#8221; button_letter_spacing=&#8221;0&#8243; button_use_icon=&#8221;default&#8221; button_icon_placement=&#8221;right&#8221; button_on_hover=&#8221;on&#8221; button_letter_spacing_hover=&#8221;0&#8243; module_class=&#8221;content_box content_box_dark_bg&#8221; _builder_version=&#8221;3.17.6&#8243;]<\/p>\n<p style=\"text-align: center;font-size: 2em\">32<\/p>\n<p style=\"text-align: center\">Sub-projects and 30 early career researchers<\/p>\n<p>[\/et_pb_cta][\/et_pb_column][\/et_pb_row][et_pb_row][et_pb_column type=&#8221;4_4&#8243;][et_pb_text admin_label=&#8221;Spacing only&#8221; _builder_version=&#8221;3.17.6&#8243;]<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>[\/et_pb_text][et_pb_text admin_label=&#8221;Title: Papers, reports and resources&#8221; _builder_version=&#8221;3.17.6&#8243;]<\/p>\n<h2 id=\"papers\">Our findings<\/h2>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row][et_pb_column type=&#8221;1_2&#8243;][et_pb_text admin_label=&#8221;Text: Papers, reports and resources &#8211; LHS&#8221; _builder_version=&#8221;3.17.6&#8243;]<\/p>\n<p class=\"subHeading\" style=\"color: #14516e\">See the latest publications and findings from the MASTERPLANS project.<\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_2&#8243;][et_pb_text admin_label=&#8221;Text: Papers&#8221; _builder_version=&#8221;3.17.6&#8243;]<\/p>\n<h3>Papers<\/h3>\n<p>All of our publications can be found on the University&#8217;s Research Explorer.<\/p>\n<p>[\/et_pb_text][et_pb_button admin_label=&#8221;Button: Publications&#8221; _builder_version=&#8221;3.17.6&#8243; button_text=&#8221;View publications&#8221; button_url=&#8221;https:\/\/www.research.manchester.ac.uk\/portal\/en\/projects\/maximising-sle-therapeutic-potential-by-application-of-novel-and-systematic-approaches-masterplans(acc869dd-428c-4147-9175-b99234f603d1).html&#8221; \/][et_pb_text admin_label=&#8221;Text: Reports and resources &#8211; RHS&#8221; _builder_version=&#8221;3.17.6&#8243;]<\/p>\n<h3>Patient involvement resources<\/h3>\n<ul>\n<li><a href=\"https:\/\/documents.manchester.ac.uk\/display.aspx?DocID=53264\">PPI strategy and implementation plan (PDF)<\/a><\/li>\n<li><a href=\"https:\/\/documents.manchester.ac.uk\/display.aspx?DocID=53262\">Lay report on PPI impact (PDF)<\/a><\/li>\n<li>Information for patient collaborators:\n<ul>\n<li><a href=\"https:\/\/documents.manchester.ac.uk\/display.aspx?DocID=53267\">PPI reward and recognition (PDF)<\/a><\/li>\n<li><a href=\"https:\/\/documents.manchester.ac.uk\/display.aspx?DocID=53265\">Opportunities for patient collaborators (PDF)<\/a><\/li>\n<li><a href=\"https:\/\/documents.manchester.ac.uk\/display.aspx?DocID=53263\">MASTERPLANS committees (PDF)<\/a><\/li>\n<li><a href=\"https:\/\/documents.manchester.ac.uk\/display.aspx?DocID=53258\">Data protection statement for PPI (PDF)<\/a><\/li>\n<li><a href=\"https:\/\/documents.manchester.ac.uk\/display.aspx?DocID=53266\">PPI confidentiality undertaking (PDF)<\/a><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h3>Resources for future SLE studies<\/h3>\n<p>The PLANS study, a sub-project of MASTERPLANS, was an exemplar of how to collect multiple biological samples for several distant project partners.<\/p>\n<p>Download standard operating procedures for:<\/p>\n<ul>\n<li><a href=\"https:\/\/documents.manchester.ac.uk\/display.aspx?DocID=53252\">Blood and urine collection\u00a0(PDF)<\/a><\/li>\n<li><a href=\"https:\/\/documents.manchester.ac.uk\/display.aspx?DocID=53255\">Skin sample collection (PDF)<\/a><\/li>\n<li><a href=\"https:\/\/documents.manchester.ac.uk\/display.aspx?DocID=53253\">Sample processing at hubs (PDF)<\/a><\/li>\n<\/ul>\n<p>PLANS closed prematurely because of recruitment difficulties, an issue that causes many lupus studies to close early. We conducted a lessons learnt review:<\/p>\n<ul>\n<li><a href=\"https:\/\/documents.manchester.ac.uk\/display.aspx?DocID=53249\">PLANS lessons learnt (PDF)<\/a><\/li>\n<\/ul>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row][et_pb_column type=&#8221;4_4&#8243;][et_pb_text admin_label=&#8221;Spacing &amp; back to top&#8221; _builder_version=&#8221;3.17.6&#8243;]<\/p>\n<p><a href=\"#intro\">&lt; Back to top<\/a>\u00a0<\/p>\n<p>[\/et_pb_text][et_pb_image admin_label=&#8221;Image: Purple butterflies&#8221; _builder_version=&#8221;3.17.6&#8243; src=&#8221;https:\/\/sites.manchester.ac.uk\/masterplans\/wp-content\/uploads\/sites\/288\/2021\/02\/lupus-purple-butterflies.jpg&#8221; \/][et_pb_text admin_label=&#8221;Spacing only&#8221; _builder_version=&#8221;3.17.6&#8243;]<\/p>\n<p>\n&nbsp;<\/p>\n<p>[\/et_pb_text][et_pb_text admin_label=&#8221;Title: Patient and public involvement&#8221; _builder_version=&#8221;3.17.6&#8243;]<\/p>\n<h2 id=\"ppi\">Patient and public involvement<\/h2>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row][et_pb_column type=&#8221;1_2&#8243;][et_pb_text admin_label=&#8221;Text: Patient and public involvement &#8211; LHS&#8221; _builder_version=&#8221;3.17.6&#8243;]<\/p>\n<p class=\"subHeading\" style=\"color: #14516e\">MASTERPLANS is an exemplar of good patient and public involvement (PPI) practice in a large multi-disciplinary basic science project.<\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_2&#8243;][et_pb_text admin_label=&#8221;Text: Patient and public involvement &#8211; RHS&#8221; _builder_version=&#8221;3.17.6&#8243;]<\/p>\n<p>Our very active PPI group was embedded throughout MASTERPLANS, contributing to:<\/p>\n<ul>\n<li>the grant application process;<\/li>\n<li>PPI planning;<\/li>\n<li>project planning and oversight through committee membership;<\/li>\n<li>design of the PLANS study and research governance;<\/li>\n<li>commenting on emerging results including the algorithms;<\/li>\n<li>communications to the patient community;<\/li>\n<li>evaluation of the impact of PPI in MASTERPLANS.<\/li>\n<\/ul>\n<p>For more information, see our PPI resources linked in the <a title=\"https:\/\/sites.manchester.ac.uk\/masterplans\/#papers\" href=\"https:\/\/sites.manchester.ac.uk\/masterplans\/#papers\" target=\"_blank\" rel=\"noopener noreferrer\">section above<\/a>.<\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row][et_pb_column type=&#8221;4_4&#8243;][et_pb_text admin_label=&#8221;Spacing &amp; back to top&#8221; _builder_version=&#8221;3.17.6&#8243;]<\/p>\n<p><a href=\"#intro\">&lt; Back to top<\/a>\u00a0<\/p>\n<p>[\/et_pb_text][et_pb_divider _builder_version=&#8221;3.17.6&#8243; \/][et_pb_text admin_label=&#8221;Text: Patient partner quote&#8221; _builder_version=&#8221;3.17.6&#8243;]<\/p>\n<div style=\"width: 18%;float: left\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-1455 alignleft\" src=\"https:\/\/sites.manchester.ac.uk\/masterplans\/wp-content\/uploads\/sites\/288\/2021\/02\/lupus-purple-butterflies-sml.jpg\" alt=\"Three purple butterflies.\" width=\"150\" height=\"146\" \/><\/div>\n<div style=\"width: 82%;float: left\">\n<p style=\"font-weight: 500;color: #28a0d8;font-size: 1.25em\">\u201cThe participation of patients in clinical trials and studies has led to some amazing breakthroughs in the treatment of serious illnesses. Involvement in research can be very rewarding, educational and, from my experience, can give you a sense of purpose and control at a time when you feel very helpless. Lupus is a devastating and cruel disease and we are in desperate need of faster, more effective treatments not only for ourselves but for future generations. Research is vital in giving us a better chance of beating it.\u201d<\/p>\n<p><strong>Patient collaborator<\/strong> \/ MASTERPLANS<\/p>\n<\/div>\n<div style=\"clear: both\"><\/div>\n<p>[\/et_pb_text][et_pb_divider _builder_version=&#8221;3.17.6&#8243; \/][et_pb_text admin_label=&#8221;Spacing only&#8221; _builder_version=&#8221;3.17.6&#8243;]<\/p>\n<p>\n&nbsp;<\/p>\n<p>[\/et_pb_text][et_pb_text admin_label=&#8221;Title: Partners and patient collaborators&#8221; _builder_version=&#8221;3.17.6&#8243;]<\/p>\n<h2 id=\"collaborators\">Partners and collaborators<\/h2>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row][et_pb_column type=&#8221;1_2&#8243;][et_pb_text admin_label=&#8221;Text: Partners and patient collaborators &#8211; LHS&#8221; _builder_version=&#8221;3.17.6&#8243;]<\/p>\n<p class=\"subHeading\" style=\"color: #14516e\">Ten academic and ten industry partners worked in collaboration with 18 patients and carers on the project.<\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_2&#8243;][et_pb_accordion admin_label=&#8221;Accordion: Partners and patient collaborators&#8221; _builder_version=&#8221;3.17.6&#8243;][et_pb_accordion_item _builder_version=&#8221;3.17.6&#8243; title=&#8221;Academic&#8221;]<\/p>\n<ul>\n<li>The University of Manchester\n<ul>\n<li>Centre for Epidemiology<\/li>\n<li>Health eResearch Centre<\/li>\n<li>Health Economics<\/li>\n<\/ul>\n<\/li>\n<li>University of Bath<\/li>\n<li>University of Birmingham<\/li>\n<li>University of Cambridge<\/li>\n<li>MRC Biostatistics Unit, Cambridge<\/li>\n<li>Imperial College London<\/li>\n<li>King\u2019s College London<\/li>\n<li>University of Liverpool<\/li>\n<li>University of Leeds<\/li>\n<li>University College London<\/li>\n<\/ul>\n<p>[\/et_pb_accordion_item][et_pb_accordion_item _builder_version=&#8221;3.17.6&#8243; title=&#8221;Industry&#8221;]<\/p>\n<ul>\n<li>Aeirtec Limited<\/li>\n<li>Aurinia Pharmaceuticals Inc.<\/li>\n<li>Epistem Limited<\/li>\n<li>Genentech, Inc.<\/li>\n<li>GlaxoSmithKline plc<\/li>\n<li>Imagen Therapeutics Ltd.<\/li>\n<li>Medimmune Limited<\/li>\n<li>Myriad RBM, Inc.<\/li>\n<li>Pfizer Limited<\/li>\n<li>UCB Pharma S.A.<\/li>\n<\/ul>\n<p>[\/et_pb_accordion_item][et_pb_accordion_item _builder_version=&#8221;3.17.6&#8243; title=&#8221;Patient collaborators&#8221;]<\/p>\n<p>18 lupus patients and carers made up the MASTERPLANS patient and public involvement group.<\/p>\n<p>[\/et_pb_accordion_item][\/et_pb_accordion][\/et_pb_column][\/et_pb_row][et_pb_row][et_pb_column type=&#8221;4_4&#8243;][et_pb_text admin_label=&#8221;Spacing &amp; back to top&#8221; _builder_version=&#8221;3.17.6&#8243;]<\/p>\n<p><a href=\"#intro\">&lt; Back to top<\/a>\u00a0<\/p>\n<p>[\/et_pb_text][et_pb_divider _builder_version=&#8221;3.17.6&#8243; \/][et_pb_text admin_label=&#8221;Text: Ian Bruce quote&#8221; _builder_version=&#8221;3.17.6&#8243;]<\/p>\n<div style=\"width: 18%;float: left\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-1460\" src=\"https:\/\/sites.manchester.ac.uk\/masterplans\/wp-content\/uploads\/sites\/288\/2021\/02\/ian-bruce.jpg\" alt=\"Professor Ian Bruce\" width=\"150\" height=\"150\" \/><\/div>\n<div style=\"width: 82%;float: left\">\n<p style=\"font-weight: 500;color: #28a0d8;font-size: 1.25em\">\u201cMASTERPLANS brought together clinical academics, researchers, industry and patients from across the lupus community, working towards a common goal of improving the lives of lupus patients. This has built a legacy of collaboration to support further lupus research in future years.\u201d<\/p>\n<p><strong>Professor Ian Bruce<\/strong> \/ Principal Investigator, The University of Manchester<\/p>\n<\/div>\n<div style=\"clear: both\"><\/div>\n<p>[\/et_pb_text][et_pb_divider _builder_version=&#8221;3.17.6&#8243; \/][et_pb_text admin_label=&#8221;Spacing only&#8221; _builder_version=&#8221;3.17.6&#8243;]<\/p>\n<p>\n&nbsp;<\/p>\n<p>[\/et_pb_text][et_pb_text admin_label=&#8221;Title: Contact us&#8221; _builder_version=&#8221;3.17.6&#8243;]<\/p>\n<h2 id=\"contact\">Contact us<\/h2>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row][et_pb_column type=&#8221;1_2&#8243;][et_pb_text admin_label=&#8221;Text: Contact us &#8211; LHS&#8221; _builder_version=&#8221;3.17.6&#8243;]<\/p>\n<p class=\"subHeading\" style=\"color: #14516e\">Get in touch if you have any questions.<\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_2&#8243;][et_pb_text admin_label=&#8221;Text: Contact us &#8211; RHS&#8221; _builder_version=&#8221;3.17.6&#8243;]<\/p>\n<p>\nEmail: <a href=\"mailto:masterplans@manchester.ac.uk\">masterplans@manchester.ac.uk<\/a><\/p>\n<p><strong>Centre for Epidemiology Versus Arthritis<\/strong><br \/>Second floor, Stopford Building<br \/>The University of Manchester<br \/>Oxford Road<br \/>Manchester<br \/>M13 9PT<\/p>\n<p>&nbsp;<br \/><strong>Find us<\/strong><\/p>\n<p>Our building is number 79 on the\u00a0<a href=\"http:\/\/www.manchester.ac.uk\/discover\/maps\/\">campus map<\/a>.<\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row][et_pb_column type=&#8221;4_4&#8243;][et_pb_text admin_label=&#8221;Spacing &amp; back to top&#8221; _builder_version=&#8221;3.17.6&#8243;]<\/p>\n<p><a href=\"#intro\">&lt; Back to top<\/a>\u00a0<\/p>\n<p>[\/et_pb_text][et_pb_divider _builder_version=&#8221;3.17.6&#8243; \/][et_pb_text admin_label=&#8221;Spacing only&#8221; _builder_version=&#8221;3.17.6&#8243;]<\/p>\n<p>&nbsp;<\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row][et_pb_column type=&#8221;1_3&#8243;][et_pb_image admin_label=&#8221;Image: MASTERPLANS logo&#8221; _builder_version=&#8221;3.17.6&#8243; src=&#8221;https:\/\/sites.manchester.ac.uk\/masterplans\/wp-content\/uploads\/sites\/288\/2021\/02\/masterplans-logo.jpg&#8221; \/][\/et_pb_column][et_pb_column type=&#8221;1_3&#8243;][et_pb_image admin_label=&#8221;Image:Lupus logo&#8221; _builder_version=&#8221;3.17.6&#8243; src=&#8221;https:\/\/sites.manchester.ac.uk\/masterplans\/wp-content\/uploads\/sites\/288\/2021\/02\/lupus.jpg&#8221; \/][\/et_pb_column][et_pb_column type=&#8221;1_3&#8243;][et_pb_image admin_label=&#8221;Image: MRC logo&#8221; _builder_version=&#8221;3.17.6&#8243; src=&#8221;https:\/\/sites.manchester.ac.uk\/masterplans\/wp-content\/uploads\/sites\/288\/2021\/02\/mrc-logo.png&#8221; \/][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section bb_built=&#8221;1&#8243; admin_label=&#8221;Connect Title&#8221; custom_padding=&#8221;0px||0px|&#8221; _builder_version=&#8221;3.0.90&#8243; background_color=&#8221;#1d1d1d&#8221; module_class=&#8221;footer-section&#8221; prev_background_color=&#8221;#ffffff&#8221; global_module=&#8221;380&#8243;][et_pb_row admin_label=&#8221;row&#8221; global_parent=&#8221;380&#8243; locked=&#8221;off&#8221; allow_player_pause=&#8221;off&#8221; parallax=&#8221;off&#8221; parallax_method=&#8221;on&#8221; parallax_1=&#8221;off&#8221; parallax_method_1=&#8221;off&#8221; parallax_2=&#8221;off&#8221; parallax_method_2=&#8221;off&#8221; parallax_3=&#8221;off&#8221; parallax_method_3=&#8221;off&#8221; make_fullwidth=&#8221;off&#8221; use_custom_width=&#8221;off&#8221; width_unit=&#8221;on&#8221; use_custom_gutter=&#8221;off&#8221; make_equal=&#8221;off&#8221; module_id=&#8221;footer-row&#8221; _builder_version=&#8221;3.0.89&#8243;][et_pb_column type=&#8221;1_3&#8243;][et_pb_text admin_label=&#8221;Contact Us Title&#8221; global_parent=&#8221;380&#8243; background_layout=&#8221;dark&#8221; text_text_color=&#8221;#ffffff&#8221; parent_locked=&#8221;off&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; background_size=&#8221;initial&#8221;]<\/p>\n<h4>Contact Us<\/h4>\n<p>[\/et_pb_text][et_pb_text admin_label=&#8221;Contact Us&#8221; global_parent=&#8221;380&#8243; text_text_color=&#8221;#aaaaaa&#8221; parent_locked=&#8221;off&#8221; background_layout=&#8221;light&#8221; text_orientation=&#8221;left&#8221; use_border_color=&#8221;off&#8221; border_color=&#8221;#ffffff&#8221; border_style=&#8221;solid&#8221; module_class=&#8221;contact-us&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; background_size=&#8221;initial&#8221;]<\/p>\n<p>+44 (0) 161 306 6000<\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_3&#8243;][et_pb_text admin_label=&#8221;Find Us Title&#8221; global_parent=&#8221;380&#8243; background_layout=&#8221;dark&#8221; text_text_color=&#8221;#ffffff&#8221; parent_locked=&#8221;off&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; background_size=&#8221;initial&#8221;]<\/p>\n<h4>Find Us<\/h4>\n<p>[\/et_pb_text][et_pb_text admin_label=&#8221;Address&#8221; global_parent=&#8221;380&#8243; background_layout=&#8221;dark&#8221; text_orientation=&#8221;left&#8221; use_border_color=&#8221;off&#8221; border_color=&#8221;#ffffff&#8221; border_style=&#8221;solid&#8221; module_id=&#8221;address&#8221; parent_locked=&#8221;off&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; background_size=&#8221;initial&#8221;]<\/p>\n<p><a href=\"http:\/\/www.manchester.ac.uk\/discover\/maps\/interactive-map\/\">The University of Manchester<br \/>Oxford Rd<br \/>Manchester<br \/>M13 9PL<br \/>UK<\/a><\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_3&#8243;][et_pb_text admin_label=&#8221;Connect Title&#8221; global_parent=&#8221;380&#8243; background_layout=&#8221;dark&#8221; text_text_color=&#8221;#ffffff&#8221; parent_locked=&#8221;off&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; background_size=&#8221;initial&#8221;]<\/p>\n<h4>Connect With Us<\/h4>\n<p>[\/et_pb_text][et_pb_code admin_label=&#8221;Social Media&#8221; global_parent=&#8221;380&#8243; parent_locked=&#8221;off&#8221; _builder_version=&#8221;3.17.6&#8243;]<\/p>\n<ul class=\"inlineList footer-socialIcons\"><!-- [et_pb_line_break_holder] --><\/p>\n<li><!-- [et_pb_line_break_holder] --> <a href=\"https:\/\/www.facebook.com\/TheUniversityOfManchester\"><!-- [et_pb_line_break_holder] --> <img loading=\"lazy\" decoding=\"async\" src=\"\/\/assets.manchester.ac.uk\/phase1\/templates\/images\/icon-facebook-50.png\" alt=\"Facebook page for The University of Manchester\" width=\"40\" height=\"40\" \/><!-- [et_pb_line_break_holder] --> <\/a><!-- [et_pb_line_break_holder] --><\/li>\n<p><!-- [et_pb_line_break_holder] --><\/p>\n<li><!-- [et_pb_line_break_holder] --> <a href=\"https:\/\/twitter.com\/OfficialUoM\"><!-- [et_pb_line_break_holder] --> <img loading=\"lazy\" decoding=\"async\" src=\"\/\/assets.manchester.ac.uk\/phase1\/templates\/images\/icon-twitter-50.png\" alt=\"Twitter page for The University of Manchester\" width=\"40\" height=\"40\" \/><!-- [et_pb_line_break_holder] --> <\/a><!-- [et_pb_line_break_holder] --><\/li>\n<p><!-- [et_pb_line_break_holder] --><\/p>\n<li><!-- [et_pb_line_break_holder] --> <a href=\"http:\/\/www.youtube.com\/universitymanchester\"><!-- [et_pb_line_break_holder] --> <img loading=\"lazy\" decoding=\"async\" src=\"\/\/assets.manchester.ac.uk\/phase1\/templates\/images\/icon-youtube-50.png\" alt=\"YouTube page for The University of Manchester\" width=\"40\" height=\"40\" \/><!-- [et_pb_line_break_holder] --> <\/a><!-- [et_pb_line_break_holder] --><\/li>\n<p><!-- [et_pb_line_break_holder] --><\/p>\n<li><!-- [et_pb_line_break_holder] --> <a href=\"https:\/\/instagram.com\/officialuom\/\"><!-- [et_pb_line_break_holder] --> <!-- [et_pb_line_break_holder] --> <img loading=\"lazy\" decoding=\"async\" src=\"\/\/assets.manchester.ac.uk\/phase1\/templates\/images\/icon-instagram-50.svg\" alt=\"Instagram page for The University of Manchester\" width=\"40\" height=\"40\" \/><!-- [et_pb_line_break_holder] --> <\/a><!-- [et_pb_line_break_holder] --><\/li>\n<p><!-- [et_pb_line_break_holder] --><\/ul>\n<p>[\/et_pb_code][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>MAximizing Sle ThERapeutic PotentiaL by Application of Novel and Stratified approaches &nbsp; &nbsp; <div class=\"et_pb_row et_pb_row_0 et_pb_row_empty\">\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t<\/div> Identifying predictors of response to drugs in systemic lupus erythematosus (SLE) patients. The MASTERPLANS project (2015-2021), led by Professor Ian Bruce, identified groups of patients that respond well or less well to particular drugs. We analysed a range of datasets and [&hellip;]<\/p>\n","protected":false},"author":4,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","_exactmetrics_skip_tracking":false,"footnotes":""},"class_list":["post-1423","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/sites.manchester.ac.uk\/masterplans\/wp-json\/wp\/v2\/pages\/1423","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.manchester.ac.uk\/masterplans\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sites.manchester.ac.uk\/masterplans\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sites.manchester.ac.uk\/masterplans\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.manchester.ac.uk\/masterplans\/wp-json\/wp\/v2\/comments?post=1423"}],"version-history":[{"count":31,"href":"https:\/\/sites.manchester.ac.uk\/masterplans\/wp-json\/wp\/v2\/pages\/1423\/revisions"}],"predecessor-version":[{"id":1478,"href":"https:\/\/sites.manchester.ac.uk\/masterplans\/wp-json\/wp\/v2\/pages\/1423\/revisions\/1478"}],"wp:attachment":[{"href":"https:\/\/sites.manchester.ac.uk\/masterplans\/wp-json\/wp\/v2\/media?parent=1423"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}