Contact details

Name: Professor Cliona Kirwan

Job title: Professor of Surgical Trials and Consultant Oncoplastic Breast Surgeon

Location: Manchester University Foundation Trust

Email: cliona.kirwan@manchester.ac.uk

Specialities and research

Speciality

• Breast surgery

Sub-speciality

• Oncoplastic breast surgery

Research interests

• Cancer and thrombosis
• Surgical trials (CTIMPS and device) including de-escalation of treatment trials

Type of research

• Audit
• Device study
• CTIMP
• Clinical trials

Clinical trial experience

Chief investigator

• Thrombin Inhibition preoperatively in early breast cancer (TIP) – CTIMP window of opportunity RCT.
• T-Poetic (Thrombin Pathway in ‘PeriOperative Endocrine Treatment for Individualizing Care’): a biomarker substudy of the POETIC trial correlating stromal clotting markers with response to endocrine therapy in early breast cancer.
• Patient and public priorities for breast cancer research: a qualitative study and prioritisation exercise in the UK.

Co-investigator

• PRIMETIME (Biomarker directed avoidance of radiotherapy in early breast cancer)
• POETIC-A (Adjuvant Abemaciclib RCT in endocrine-resistant early breast cancer)
• LORIS Trial: A phase III trial of surgery versus active monitoring for low risk ductal carcinoma in situ (DCIS)
• MagTech: A cost-effectiveness study. Magtrace in sentinel node biopsy for breast cancer.

Principal investigator

• Serena-3 (Oral Selective Oestrogen Receptor Downregulator Window of Opportunity CTIMP Trial in early breast cancer).
• SMALL (RCT of vacuum excision of small low-risk breast cancers vs SOC).

Postgraduate supervision

Cliona is currently a PhD/MD supervisor.

More information

• Research profile
• Consultant profile

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