Publications

 

2021

 

Marinopoulou, E., Biga, V., Sabherwal, N., Miller, A., Desai, J., Adamson, A.D., Papalopulu, N., 2021. HES1 protein oscillations are necessary for neural stem cells to exit from quiescence. iScience 24, 103198. https://doi.org/10.1016/j.isci.2021.103198

 

Morris, E.L., Patton, A.P., Chesham, J.E., Crisp, A., Adamson, A., Hastings, M.H., 2021. Single-cell transcriptomics of suprachiasmatic nuclei reveal a Prokineticin-driven circadian network. EMBO J e108614. https://doi.org/10.15252/embj.2021108614

 

Bennett, H., Aguilar-Martinez, E., Adamson, A.D., 2021. CRISPR-mediated knock-in in the mouse embryo using long single stranded DNA donors synthesised by biotinylated PCR. Methods 191, 3–14. https://doi.org/10.1016/j.ymeth.2020.10.012

 

Biga, V., Hawley, J., Soto, X., Johns, E., Han, D., Bennett, H., Adamson, A.D., Kursawe, J., Glendinning, P., Manning, C.S., Papalopulu, N., 2021. A dynamic, spatially periodic, micro-pattern of HES5 underlies neurogenesis in the mouse spinal cord. Molecular Systems Biology 17, e9902. https://doi.org/10.15252/msb.20209902

 

Gurumurthy, C.B., O’Brien, A.R., Quadros, R.M., Adams, J., Alcaide, P., Ayabe, S., Ballard, J., Batra, S.K., Beauchamp, M.-C., Becker, K.A., Bernas, G., Brough, D., Carrillo-Salinas, F., Chan, W., Chen, H., Dawson, R., DeMambro, V., D’Hont, J., Dibb, K., Eudy, J.D., Gan, L., Gao, J., Gonzales, A., Guntur, A., Guo, H., Harms, D.W., Harrington, A., Hentges, K.E., Humphreys, N., Imai, S., Ishii, H., Iwama, M., Jonasch, E., Karolak, M., Keavney, B., Khin, N.-C., Konno, M., Kotani, Y., Kunihiro, Y., Lakshmanan, I., Larochelle, C., Lawrence, C.B., Li, L., Lindner, V., Liu, X.-D., Lopez-Castejon, G., Loudon, A., Lowe, J., Jerome-Majeweska, L., Matsusaka, T., Miura, H., Miyasaka, Y., Morpurgo, B., Motyl, K., Nabeshima, Y., Nakade, K., Nakashiba, T., Nakashima, K., Obata, Y., Ogiwara, S., Ouellet, M., Oxburgh, L., Piltz, S., Pinz, I., Ponnusamy, M.P., Ray, D., Redder, R.J., Rosen, C.J., Ross, N., Ruhe, M.T., Ryzhova, L., Salvador, A.M., Alam, S.S., Sedlacek, R., Sharma, K., Smith, C., Staes, K., Starrs, L., Sugiyama, F., Takahashi, S., Tanaka, T., Trafford, A., Uno, Y., Vanhoutte, L., Vanrockeghem, F., Willis, B.J., Wright, C.S., Yamauchi, Y., Yi, X., Yoshimi, K., Zhang, X., Zhang, Y., Ohtsuka, M., Das, S., Garry, D.J., Hochepied, T., Thomas, P., Parker-Thornburg, J., Adamson, A.D., Yoshiki, A., Schmouth, J.-F., Golovko, A., Thompson, W.R., Lloyd, K.C.K., Wood, J.A., Cowan, M., Mashimo, T., Mizuno, S., Zhu, H., Kasparek, P., Liaw, L., Miano, J.M., Burgio, G., 2021. Response to correspondence on “Reproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles: a multi-center evaluation.” Genome Biol 22, 1–4. https://doi.org/10.1186/s13059-021-02320-3

 

Hunter, A.L., Pelekanou, C.E., Barron, N.J., Northeast, R.C., Grudzien, M., Adamson, A.D., Downton, P., Cornfield, T., Cunningham, P.S., Billaud, J.-N., Hodson, L., Loudon, A.S., Unwin, R.D., Iqbal, M., Ray, D.W., Bechtold, D.A., 2021. Adipocyte NR1D1 dictates adipose tissue expansion during obesity. eLife 10, e63324. https://doi.org/10.7554/eLife.63324

 

McNamara, A.V., Awais, R., Momiji, H., Dunham, L., Featherstone, K., Harper, C.V., Adamson, A.D., Semprini, S., Jones, N.A., Spiller, D.G., Mullins, J.J., Finkenstädt, B.F., Rand, D., White, M.R.H., Davis, J.R.E., 2021. Transcription factor Pit-1 affects transcriptional timing in the dual-promoter human prolactin gene. Endocrinology. https://doi.org/10.1210/endocr/bqaa249

 

Thieme, F., Henschel, L., Hammond, N.L., Ishorst, N., Hausen, J., Adamson, A.D., Biedermann, A., Bowes, J., Zieger, H.K., Maj, C., Kruse, T., Buness, A., Hoischen, A., Gilissen, C., Kreusch, T., Jäger, A., Gölz, L., Braumann, B., Aldhorae, K., Rojas-Martinez, A., Krawitz, P.M., Mangold, E., Dixon, M.J., Ludwig, K.U., 2021. Extending the allelic spectrum at noncoding risk loci of orofacial clefting. Hum Mutat 42, 1066–1078. https://doi.org/10.1002/humu.24219

 

Preprints

 

Bagnall, J.S., Koch, A.A., Smyllie, N.J., Begley, N., Adamson, A., Fribourgh, J.L., Spiller, D.G., Meng, Q.-J., Partch, C.L., Strimmer, K., House, T.A., Hastings, M.H., Loudon, A.S.I., 2021. Quantification of circadian interactions and protein abundance defines a mechanism for operational stability of the circadian clock. https://doi.org/10.1101/2021.08.27.456017

 

Lee, B., Hoyle, C., Green, J.P., Wellens, R., Martin-Sanchez, F., Williams, D., Seoane, P.I., Bennett, H., Adamson, A., Lopez-Castejon, G., Lowe, M., Brough, D., 2021. NLRP3 activation in response to disrupted endocytic traffic. https://doi.org/10.1101/2021.09.15.460426

 

Jayadev, R., Morais, M.R., Ellingford, J.M., Srinivasan, S., Naylor, R.W., Lawless, C., Li, A.S., Ingham, J.F., Hastie, E., Chi, Q., Fresquet, M., Koudis, N.-M., Thomas, H.B., O’Keefe, R.T., Williams, E., Adamson, A., Stuart, H.M., Banka, S., Smedley, D., Consortium, G.E.R., Sherwood, D.R., Lennon, R., 2021. A basement membrane discovery pipeline uncovers network complexity, new regulators, and human disease associations. https://doi.org/10.1101/2021.10.25.465762

 

Atherton, P., Konstantinou, R., Neo, S.P., Wang, E., Balloi, E., Ptushkina, M., Bennett, H., Clark, K., Gunaratne, J., Critchley, D., Barsukov, I., Manser, E., Ballestrem, C., 2021. Tensin3 interaction with talin drives formation of fibronectin-associated fibrillar adhesions. https://doi.org/10.1101/2021.07.16.452612

 

Gemperle, J., Harrison, T., Flett, C., Adamson, A., Caswell, P., 2021. DExCon, DExogron, LUXon: on-demand expression control of endogenous genes reveals differential dynamics of Rab11 family members. https://doi.org/10.1101/2021.12.03.471086

 

Stables, J., Green, E.K., Sehgal, A., Patkar, O., Keshvari, S., Taylor, I., Ashcroft, M.E., Grabert, K., Wollscheid-Lengeling, E., Szymkowiak, S., McColl, B.W., Adamson, A., Humphreys, N.E., Mueller, W., Starobova, H., Vetter, I., Shabestari, S.K., Blurton-Jones, M.M., Summers, K.M., Irvine, K.M., Pridans, C., Hume, D.A., 2021. A kinase-dead Csf1r mutation associated with adult-onset leukoencephalopathy has a dominant-negative impact on CSF1R signaling. https://doi.org/10.1101/2021.09.29.462493

 

 

 

2020

 

Al Kindi, A., Williams, H., Matsuda, K., Alkahtani, A.M., Saville, C., Bennett, H., Alshammari, Y., Tan, S.Y., O’Neill, C., Tanaka, A., Matsuda, H., Arkwright, P.D., Pennock, J.L., 2021. Staphylococcus aureus second immunoglobulin-binding protein drives atopic dermatitis via IL-33. J Allergy Clin Immunol 147, 1354-1368.e3. https://doi.org/10.1016/j.jaci.2020.09.023

 

Baxter, M., Voronkov, M., Poolman, T., Galli, G., Pinali, C., Goosey, L., Knight, A., Krakowiak, K., Maidstone, R., Iqbal, M., Zi, M., Prehar, S., Cartwright, E.J., Gibbs, J., Matthews, L.C., Adamson, A.D., Humphreys, N.E., Rebelo-Guiomar, P., Minczuk, M., Bechtold, D.A., Loudon, A., Ray, D., 2020. Cardiac mitochondrial function depends on BUD23 mediated ribosome programming. Elife 9. https://doi.org/10.7554/eLife.50705

 

Chang, J., Garva, R., Pickard, A., Yeung, C.-Y.C., Mallikarjun, V., Swift, J., Holmes, D.F., Calverley, B., Lu, Y., Adamson, A., Raymond-Hayling, H., Jensen, O., Shearer, T., Meng, Q.J., Kadler, K.E., 2020. Circadian control of the secretory pathway maintains collagen homeostasis. Nat. Cell Biol. 22, 74–86. https://doi.org/10.1038/s41556-019-0441-z

 

Evans, E.L., Povstyan, O.V., De Vecchis, D., Macrae, F., Lichtenstein, L., Futers, T.S., Parsonage, G., Humphreys, N.E., Adamson, A., Kalli, A.C., Ludlow, M.J., Beech, D.J., 2020. RBCs prevent rapid PIEZO1 inactivation and expose slow deactivation as a mechanism of dehydrated hereditary stomatocytosis. Blood 136, 140–144. https://doi.org/10.1182/blood.2019004174

 

Grabert, K., Sehgal, A., Irvine, K.M., Wollscheid-Lengeling, E., Ozdemir, D.D., Stables, J., Luke, G.A., Ryan, M.D., Adamson, A., Humphreys, N.E., Sandrock, C.J., Rojo, R., Verkasalo, V.A., Mueller, W., Hohenstein, P., Pettit, A.R., Pridans, C., Hume, D.A., 2020. A Transgenic Line That Reports CSF1R Protein Expression Provides a Definitive Marker for the Mouse Mononuclear Phagocyte System. The Journal of Immunology. https://doi.org/10.4049/jimmunol.2000835

 

Green, J.P., Swanton, T., Morris, L.V., El-Sharkawy, L.Y., Cook, J., Yu, S., Beswick, J., Adamson, A.D., Humphreys, N.E., Bryce, R., Freeman, S., Lawrence, C., Brough, D., 2020. LRRC8A is essential for hypotonicity-, but not for DAMP-induced NLRP3 inflammasome activation. eLife 9, e59704. https://doi.org/10.7554/eLife.59704

 

Hunter, A.L., Pelekanou, C.E., Adamson, A., Downton, P., Barron, N.J., Cornfield, T., Poolman, T.M., Humphreys, N., Cunningham, P.S., Hodson, L., Loudon, A.S.I., Iqbal, M., Bechtold, D.A., Ray, D.W., 2020a. Nuclear receptor REVERBα is a state-dependent regulator of liver energy metabolism. PNAS. https://doi.org/10.1073/pnas.2005330117

 

Pinteaux, E., Abdulaal, W.H., Mufazalov, I.A., Humphreys, N.E., Simonsen-Jackson, M., Francis, S., Müller, W., Waisman, A., 2020. Cell-specific conditional deletion of interleukin-1 (IL-1) ligands and its receptors: a new toolbox to study the role of IL-1 in health and disease. J Mol Med (Berl) 98, 923–930. https://doi.org/10.1007/s00109-020-01928-5

 

Ray-Jones, H., Duffus, K., McGovern, A., Martin, P., Shi, C., Hankinson, J., Gough, O., Yarwood, A., Morris, A.P., Adamson, A., Taylor, C., Ding, J., Gaddi, V.P., Fu, Y., Gaffney, P., Orozco, G., Warren, R.B., Eyre, S., 2020. Mapping DNA interaction landscapes in psoriasis susceptibility loci highlights KLF4 as a target gene in 9q31. BMC Biol. 18, 47. https://doi.org/10.1186/s12915-020-00779-3

 

Yang, J., McGovern, A., Martin, P., Duffus, K., Ge, X., Zarrineh, P., Morris, A.P., Adamson, A., Fraser, P., Rattray, M., Eyre, S., 2020. Analysis of chromatin organization and gene expression in T cells identifies functional genes for rheumatoid arthritis. Nat Commun 11, 4402. https://doi.org/10.1038/s41467-020-18180-7

 

Yang, N., Smyllie, N.J., Morris, H., Gonçalves, C.F., Dudek, M., Pathiranage, D.R.J., Chesham, J.E., Adamson, A., Spiller, D.G., Zindy, E., Bagnall, J., Humphreys, N., Hoyland, J., Loudon, A.S.I., Hastings, M.H., Meng, Q.-J., 2020. Quantitative live imaging of Venus::BMAL1 in a mouse model reveals complex dynamics of the master circadian clock regulator. PLoS Genet. 16, e1008729. https://doi.org/10.1371/journal.pgen.1008729

 

 

Preprints

 

Borland, S.J., Facchi, C., Behnsen, J., Adamson, A., Humphreys, N.E., Withers, P.J., Sherratt, M.J., Francis, S.E., Brennan, K., Ashton, N., Canfield, A.E., 2020. Loss of PKCα increases arterial medial calcification in a uremic mouse model of chronic kidney disease. bioRxiv 2020.05.20.097642. https://doi.org/10.1101/2020.05.20.097642

 

 

 

2019

 

Bageghni, S.A., Hemmings, K.E., Yuldasheva, N.Y., Maqbool, A., Gamboa-Esteves, F.O., Humphreys, N.E., Jackson, M.S., Denton, C.P., Francis, S., Porter, K.E., Ainscough, J.F., Pinteaux, E., Drinkhill, M.J., Turner, N.A., 2019. Fibroblast-specific deletion of interleukin-1 receptor-1 reduces adverse cardiac remodeling following myocardial infarction. JCI Insight 5. https://doi.org/10.1172/jci.insight.125074

 

Binder, P., Wang, S., Radu, M., Zin, M., Collins, L., Khan, S., Li, Y., Sekeres, K., Humphreys, N., Swanton, E., Reid, A., Pu, F., Oceandy, D., Guan, K., Hille, S.S., Frey, N., Müller, O.J., Cartwright, E.J., Chernoff, J., Wang, X., Liu, W., 2019. Pak2 as a Novel Therapeutic Target for Cardioprotective Endoplasmic Reticulum Stress Response. Circ. Res. 124, 696–711. https://doi.org/10.1161/CIRCRESAHA.118.312829

 

Birket, M.J., Raibaud, S., Lettieri, M., Adamson, A.D., Letang, V., Cervello, P., Redon, N., Ret, G., Viale, S., Wang, B., Biton, B., Guillemot, J.-C., Mikol, V., Leonard, J.P., Hanley, N.A., Orsini, C., Itier, J.-M., 2019. A Human Stem Cell Model of Fabry Disease Implicates LIMP-2 Accumulation in Cardiomyocyte Pathology. Stem Cell Reports 13, 380–393. https://doi.org/10.1016/j.stemcr.2019.07.004

 

Gurumurthy, C.B., O’Brien, A.R., Quadros, R.M., Adams, J., Alcaide, P., Ayabe, S., Ballard, J., Batra, S.K., Beauchamp, M.-C., Becker, K.A., Bernas, G., Brough, D., Carrillo-Salinas, F., Chan, W., Chen, H., Dawson, R., DeMambro, V., D’Hont, J., Dibb, K.M., Eudy, J.D., Gan, L., Gao, J., Gonzales, A., Guntur, A.R., Guo, H., Harms, D.W., Harrington, A., Hentges, K.E., Humphreys, N., Imai, S., Ishii, H., Iwama, M., Jonasch, E., Karolak, M., Keavney, B., Khin, N.-C., Konno, M., Kotani, Y., Kunihiro, Y., Lakshmanan, I., Larochelle, C., Lawrence, C.B., Li, L., Lindner, V., Liu, X.-D., Lopez-Castejon, G., Loudon, A., Lowe, J., Jerome-Majewska, L.A., Matsusaka, T., Miura, H., Miyasaka, Y., Morpurgo, B., Motyl, K., Nabeshima, Y.-I., Nakade, K., Nakashiba, T., Nakashima, K., Obata, Y., Ogiwara, S., Ouellet, M., Oxburgh, L., Piltz, S., Pinz, I., Ponnusamy, M.P., Ray, D., Redder, R.J., Rosen, C.J., Ross, N., Ruhe, M.T., Ryzhova, L., Salvador, A.M., Alam, S.S., Sedlacek, R., Sharma, K., Smith, C., Staes, K., Starrs, L., Sugiyama, F., Takahashi, S., Tanaka, T., Trafford, A.W., Uno, Y., Vanhoutte, L., Vanrockeghem, F., Willis, B.J., Wright, C.S., Yamauchi, Y., Yi, X., Yoshimi, K., Zhang, X., Zhang, Y., Ohtsuka, M., Das, S., Garry, D.J., Hochepied, T., Thomas, P., Parker-Thornburg, J., Adamson, A.D., Yoshiki, A., Schmouth, J.-F., Golovko, A., Thompson, W.R., Lloyd, K.C.K., Wood, J.A., Cowan, M., Mashimo, T., Mizuno, S., Zhu, H., Kasparek, P., Liaw, L., Miano, J.M., Burgio, G., 2019. Reproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles: a multi-center evaluation. Genome Biol. 20, 171. https://doi.org/10.1186/s13059-019-1776-2

 

Minshawi, F., White, M.R.H., Muller, W., Humphreys, N., Jackson, D., Campbell, B.J., Adamson, A., Papoutsopoulou, S., 2019. Human TNF-Luc reporter mouse: A new model to quantify inflammatory responses. Sci Rep 9, 193. https://doi.org/10.1038/s41598-018-36969-x

 

Sefton, C., Davies, A., Allen, T.-J., Wray, J.R., Shoop, R., Adamson, A., Humphreys, N., Coll, A.P., White, A., Harno, E., 2019. Metabolic Abnormalities of Chronic High-Dose Glucocorticoids Are Not Mediated by Hypothalamic AgRP in Male Mice. Endocrinology 160, 964–978. https://doi.org/10.1210/en.2019-00018

 

Wray, J.R., Davies, A., Sefton, C., Allen, T.-J., Adamson, A., Chapman, P., Lam, B.Y.H., Yeo, G.S.H., Coll, A.P., Harno, E., White, A., 2019. Global transcriptomic analysis of the arcuate nucleus following chronic glucocorticoid treatment. Mol Metab 26, 5–17. https://doi.org/10.1016/j.molmet.2019.05.008

 

Preprints

 

Summers, K.M., Pridans, C., Wollscheid-Lengeling, E., Grabert, K., Adamson, A., Humphreys, N.E., Irvine, K.M., Hume, D.A., 2019. Complex deletion and proximal reinsertion of a 150bp regulatory sequence in the mouse Csf1r promoter mediated by CRISPR-Cas9. bioRxiv 872200. https://doi.org/10.1101/872200

 

 

 

2018

 

Bagnall, J., Boddington, C., England, H., Brignall, R., Downton, P., Alsoufi, Z., Boyd, J., Rowe, W., Bennett, A., Walker, C., Adamson, A., Patel, N.M.X., O’Cualain, R., Schmidt, L., Spiller, D.G., Jackson, D.A., Müller, W., Muldoon, M., White, M.R.H., Paszek, P., 2018. Quantitative analysis of competitive cytokine signaling predicts tissue thresholds for the propagation of macrophage activation. Sci Signal 11. https://doi.org/10.1126/scisignal.aaf3998 

 

Harper, C.V., Woodcock, D.J., Lam, C., Garcia-Albornoz, M., Adamson, A., Ashall, L., Rowe, W., Downton, P., Schmidt, L., West, S., Spiller, D.G., Rand, D.A., White, M.R.H., 2018. Temperature regulates NF-κB dynamics and function through timing of A20 transcription. Proc. Natl. Acad. Sci. U.S.A. 115, E5243–E5249. https://doi.org/10.1073/pnas.1803609115

 

Mularczyk, E.J., Singh, M., Godwin, A.R.F., Galli, F., Humphreys, N., Adamson, A.D., Mironov, A., Cain, S.A., Sengle, G., Boot-Handford, R.P., Cossu, G., Kielty, C.M., Baldock, C., 2018. ADAMTS10-mediated tissue disruption in Weill-Marchesani syndrome. Hum. Mol. Genet. 27, 3675–3687. https://doi.org/10.1093/hmg/ddy276

 

Roostalu, U., Aldeiri, B., Albertini, A., Humphreys, N., Simonsen-Jackson, M., Wong, J.K.F., Cossu, G., 2018. Distinct Cellular Mechanisms Underlie Smooth Muscle Turnover in Vascular Development and Repair. Circ. Res. 122, 267–281. https://doi.org/10.1161/CIRCRESAHA.117.312111

 

Preprints

 

Pickard, A., Adamson, A., Lu, Y., Chang, J., Garva, R., Hodson, N., Kadler, K.E., 2018. Collagen assembly and turnover imaged with a CRISPR-Cas9 engineered Dendra2 tag (preprint). Cell Biology. https://doi.org/10.1101/331496

 

 

 

2017

 

Daniels, M.J.D., Adamson, A.D., Humphreys, N., Brough, D., 2017. CRISPR/Cas9 mediated mutation of mouse IL-1α nuclear localisation sequence abolishes expression. Scientific Reports 7, 17077. https://doi.org/10.1038/s41598-017-17387-x

 

Dudek, M., Yang, N., Ruckshanthi, J.P., Williams, J., Borysiewicz, E., Wang, P., Adamson, A., Li, J., Bateman, J.F., White, M.R., Boot-Handford, R.P., Hoyland, J.A., Meng, Q.-J., 2017. The intervertebral disc contains intrinsic circadian clocks that are regulated by age and cytokines and linked to degeneration. Ann. Rheum. Dis. 76, 576–584. https://doi.org/10.1136/annrheumdis-2016-209428

 

2016

 

Adamson, A., Boddington, C., Downton, P., Rowe, W., Bagnall, J., Lam, C., Maya-Mendoza, A., Schmidt, L., Harper, C.V., Spiller, D.G., Rand, D.A., Jackson, D.A., White, M.R.H., Paszek, P., 2016. Signal transduction controls heterogeneous NF-κB dynamics and target gene expression through cytokine-specific refractory states. Nat Commun 7, 12057. https://doi.org/10.1038/ncomms12057

 

Ankers, J.M., Awais, R., Jones, N.A., Boyd, J., Ryan, S., Adamson, A.D., Harper, C.V., Bridge, L., Spiller, D.G., Jackson, D.A., Paszek, P., Sée, V., White, M.R., 2016. Dynamic NF-κB and E2F interactions control the priority and timing of inflammatory signalling and cell proliferation. Elife 5. https://doi.org/10.7554/eLife.10473

 

McNamara, A.V., Adamson, A.D., Dunham, L.S.S., Semprini, S., Spiller, D.G., McNeilly, A.S., Mullins, J.J., Davis, J.R.E., White, M.R.H., 2016. Role of Estrogen Response Element in the Human Prolactin Gene: Transcriptional Response and Timing. Mol. Endocrinol. 30, 189–200. https://doi.org/10.1210/me.2015-1186

 

 

 

2015

 

Guo, B., Yang, N., Borysiewicz, E., Dudek, M., Williams, J.L., Li, J., Maywood, E.S., Adamson, A., Hastings, M.H., Bateman, J.F., White, M.R.H., Boot-Handford, R.P., Meng, Q.J., 2015. Catabolic cytokines disrupt the circadian clock and the expression of clock-controlled genes in cartilage via an NFкB-dependent pathway. Osteoarthr. Cartil. 23, 1981–1988. https://doi.org/10.1016/j.joca.2015.02.020

 

 

 

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