Publications
2021
Marinopoulou, E., Biga, V., Sabherwal, N., Miller, A., Desai, J., Adamson, A.D., Papalopulu, N., 2021. HES1 protein oscillations are necessary for neural stem cells to exit from quiescence. iScience 24, 103198. https://doi.org/10.1016/j.isci.2021.103198
Morris, E.L., Patton, A.P., Chesham, J.E., Crisp, A., Adamson, A., Hastings, M.H., 2021. Single-cell transcriptomics of suprachiasmatic nuclei reveal a Prokineticin-driven circadian network. EMBO J e108614. https://doi.org/10.15252/embj.2021108614
Bennett, H., Aguilar-Martinez, E., Adamson, A.D., 2021. CRISPR-mediated knock-in in the mouse embryo using long single stranded DNA donors synthesised by biotinylated PCR. Methods 191, 3–14. https://doi.org/10.1016/j.ymeth.2020.10.012
Biga, V., Hawley, J., Soto, X., Johns, E., Han, D., Bennett, H., Adamson, A.D., Kursawe, J., Glendinning, P., Manning, C.S., Papalopulu, N., 2021. A dynamic, spatially periodic, micro-pattern of HES5 underlies neurogenesis in the mouse spinal cord. Molecular Systems Biology 17, e9902. https://doi.org/10.15252/msb.20209902
Gurumurthy, C.B., O’Brien, A.R., Quadros, R.M., Adams, J., Alcaide, P., Ayabe, S., Ballard, J., Batra, S.K., Beauchamp, M.-C., Becker, K.A., Bernas, G., Brough, D., Carrillo-Salinas, F., Chan, W., Chen, H., Dawson, R., DeMambro, V., D’Hont, J., Dibb, K., Eudy, J.D., Gan, L., Gao, J., Gonzales, A., Guntur, A., Guo, H., Harms, D.W., Harrington, A., Hentges, K.E., Humphreys, N., Imai, S., Ishii, H., Iwama, M., Jonasch, E., Karolak, M., Keavney, B., Khin, N.-C., Konno, M., Kotani, Y., Kunihiro, Y., Lakshmanan, I., Larochelle, C., Lawrence, C.B., Li, L., Lindner, V., Liu, X.-D., Lopez-Castejon, G., Loudon, A., Lowe, J., Jerome-Majeweska, L., Matsusaka, T., Miura, H., Miyasaka, Y., Morpurgo, B., Motyl, K., Nabeshima, Y., Nakade, K., Nakashiba, T., Nakashima, K., Obata, Y., Ogiwara, S., Ouellet, M., Oxburgh, L., Piltz, S., Pinz, I., Ponnusamy, M.P., Ray, D., Redder, R.J., Rosen, C.J., Ross, N., Ruhe, M.T., Ryzhova, L., Salvador, A.M., Alam, S.S., Sedlacek, R., Sharma, K., Smith, C., Staes, K., Starrs, L., Sugiyama, F., Takahashi, S., Tanaka, T., Trafford, A., Uno, Y., Vanhoutte, L., Vanrockeghem, F., Willis, B.J., Wright, C.S., Yamauchi, Y., Yi, X., Yoshimi, K., Zhang, X., Zhang, Y., Ohtsuka, M., Das, S., Garry, D.J., Hochepied, T., Thomas, P., Parker-Thornburg, J., Adamson, A.D., Yoshiki, A., Schmouth, J.-F., Golovko, A., Thompson, W.R., Lloyd, K.C.K., Wood, J.A., Cowan, M., Mashimo, T., Mizuno, S., Zhu, H., Kasparek, P., Liaw, L., Miano, J.M., Burgio, G., 2021. Response to correspondence on “Reproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles: a multi-center evaluation.” Genome Biol 22, 1–4. https://doi.org/10.1186/s13059-021-02320-3
Hunter, A.L., Pelekanou, C.E., Barron, N.J., Northeast, R.C., Grudzien, M., Adamson, A.D., Downton, P., Cornfield, T., Cunningham, P.S., Billaud, J.-N., Hodson, L., Loudon, A.S., Unwin, R.D., Iqbal, M., Ray, D.W., Bechtold, D.A., 2021. Adipocyte NR1D1 dictates adipose tissue expansion during obesity. eLife 10, e63324. https://doi.org/10.7554/eLife.63324
McNamara, A.V., Awais, R., Momiji, H., Dunham, L., Featherstone, K., Harper, C.V., Adamson, A.D., Semprini, S., Jones, N.A., Spiller, D.G., Mullins, J.J., Finkenstädt, B.F., Rand, D., White, M.R.H., Davis, J.R.E., 2021. Transcription factor Pit-1 affects transcriptional timing in the dual-promoter human prolactin gene. Endocrinology. https://doi.org/10.1210/endocr/bqaa249
Thieme, F., Henschel, L., Hammond, N.L., Ishorst, N., Hausen, J., Adamson, A.D., Biedermann, A., Bowes, J., Zieger, H.K., Maj, C., Kruse, T., Buness, A., Hoischen, A., Gilissen, C., Kreusch, T., Jäger, A., Gölz, L., Braumann, B., Aldhorae, K., Rojas-Martinez, A., Krawitz, P.M., Mangold, E., Dixon, M.J., Ludwig, K.U., 2021. Extending the allelic spectrum at noncoding risk loci of orofacial clefting. Hum Mutat 42, 1066–1078. https://doi.org/10.1002/humu.24219
Preprints
Bagnall, J.S., Koch, A.A., Smyllie, N.J., Begley, N., Adamson, A., Fribourgh, J.L., Spiller, D.G., Meng, Q.-J., Partch, C.L., Strimmer, K., House, T.A., Hastings, M.H., Loudon, A.S.I., 2021. Quantification of circadian interactions and protein abundance defines a mechanism for operational stability of the circadian clock. https://doi.org/10.1101/2021.08.27.456017
Lee, B., Hoyle, C., Green, J.P., Wellens, R., Martin-Sanchez, F., Williams, D., Seoane, P.I., Bennett, H., Adamson, A., Lopez-Castejon, G., Lowe, M., Brough, D., 2021. NLRP3 activation in response to disrupted endocytic traffic. https://doi.org/10.1101/2021.09.15.460426
Jayadev, R., Morais, M.R., Ellingford, J.M., Srinivasan, S., Naylor, R.W., Lawless, C., Li, A.S., Ingham, J.F., Hastie, E., Chi, Q., Fresquet, M., Koudis, N.-M., Thomas, H.B., O’Keefe, R.T., Williams, E., Adamson, A., Stuart, H.M., Banka, S., Smedley, D., Consortium, G.E.R., Sherwood, D.R., Lennon, R., 2021. A basement membrane discovery pipeline uncovers network complexity, new regulators, and human disease associations. https://doi.org/10.1101/2021.10.25.465762
Atherton, P., Konstantinou, R., Neo, S.P., Wang, E., Balloi, E., Ptushkina, M., Bennett, H., Clark, K., Gunaratne, J., Critchley, D., Barsukov, I., Manser, E., Ballestrem, C., 2021. Tensin3 interaction with talin drives formation of fibronectin-associated fibrillar adhesions. https://doi.org/10.1101/2021.07.16.452612
Gemperle, J., Harrison, T., Flett, C., Adamson, A., Caswell, P., 2021. DExCon, DExogron, LUXon: on-demand expression control of endogenous genes reveals differential dynamics of Rab11 family members. https://doi.org/10.1101/2021.12.03.471086
Stables, J., Green, E.K., Sehgal, A., Patkar, O., Keshvari, S., Taylor, I., Ashcroft, M.E., Grabert, K., Wollscheid-Lengeling, E., Szymkowiak, S., McColl, B.W., Adamson, A., Humphreys, N.E., Mueller, W., Starobova, H., Vetter, I., Shabestari, S.K., Blurton-Jones, M.M., Summers, K.M., Irvine, K.M., Pridans, C., Hume, D.A., 2021. A kinase-dead Csf1r mutation associated with adult-onset leukoencephalopathy has a dominant-negative impact on CSF1R signaling. https://doi.org/10.1101/2021.09.29.462493
2020
Al Kindi, A., Williams, H., Matsuda, K., Alkahtani, A.M., Saville, C., Bennett, H., Alshammari, Y., Tan, S.Y., O’Neill, C., Tanaka, A., Matsuda, H., Arkwright, P.D., Pennock, J.L., 2021. Staphylococcus aureus second immunoglobulin-binding protein drives atopic dermatitis via IL-33. J Allergy Clin Immunol 147, 1354-1368.e3. https://doi.org/10.1016/j.jaci.2020.09.023
Baxter, M., Voronkov, M., Poolman, T., Galli, G., Pinali, C., Goosey, L., Knight, A., Krakowiak, K., Maidstone, R., Iqbal, M., Zi, M., Prehar, S., Cartwright, E.J., Gibbs, J., Matthews, L.C., Adamson, A.D., Humphreys, N.E., Rebelo-Guiomar, P., Minczuk, M., Bechtold, D.A., Loudon, A., Ray, D., 2020. Cardiac mitochondrial function depends on BUD23 mediated ribosome programming. Elife 9. https://doi.org/10.7554/eLife.50705
Chang, J., Garva, R., Pickard, A., Yeung, C.-Y.C., Mallikarjun, V., Swift, J., Holmes, D.F., Calverley, B., Lu, Y., Adamson, A., Raymond-Hayling, H., Jensen, O., Shearer, T., Meng, Q.J., Kadler, K.E., 2020. Circadian control of the secretory pathway maintains collagen homeostasis. Nat. Cell Biol. 22, 74–86. https://doi.org/10.1038/s41556-019-0441-z
Evans, E.L., Povstyan, O.V., De Vecchis, D., Macrae, F., Lichtenstein, L., Futers, T.S., Parsonage, G., Humphreys, N.E., Adamson, A., Kalli, A.C., Ludlow, M.J., Beech, D.J., 2020. RBCs prevent rapid PIEZO1 inactivation and expose slow deactivation as a mechanism of dehydrated hereditary stomatocytosis. Blood 136, 140–144. https://doi.org/10.1182/blood.2019004174
Grabert, K., Sehgal, A., Irvine, K.M., Wollscheid-Lengeling, E., Ozdemir, D.D., Stables, J., Luke, G.A., Ryan, M.D., Adamson, A., Humphreys, N.E., Sandrock, C.J., Rojo, R., Verkasalo, V.A., Mueller, W., Hohenstein, P., Pettit, A.R., Pridans, C., Hume, D.A., 2020. A Transgenic Line That Reports CSF1R Protein Expression Provides a Definitive Marker for the Mouse Mononuclear Phagocyte System. The Journal of Immunology. https://doi.org/10.4049/jimmunol.2000835
Green, J.P., Swanton, T., Morris, L.V., El-Sharkawy, L.Y., Cook, J., Yu, S., Beswick, J., Adamson, A.D., Humphreys, N.E., Bryce, R., Freeman, S., Lawrence, C., Brough, D., 2020. LRRC8A is essential for hypotonicity-, but not for DAMP-induced NLRP3 inflammasome activation. eLife 9, e59704. https://doi.org/10.7554/eLife.59704
Hunter, A.L., Pelekanou, C.E., Adamson, A., Downton, P., Barron, N.J., Cornfield, T., Poolman, T.M., Humphreys, N., Cunningham, P.S., Hodson, L., Loudon, A.S.I., Iqbal, M., Bechtold, D.A., Ray, D.W., 2020a. Nuclear receptor REVERBα is a state-dependent regulator of liver energy metabolism. PNAS. https://doi.org/10.1073/pnas.2005330117
Pinteaux, E., Abdulaal, W.H., Mufazalov, I.A., Humphreys, N.E., Simonsen-Jackson, M., Francis, S., Müller, W., Waisman, A., 2020. Cell-specific conditional deletion of interleukin-1 (IL-1) ligands and its receptors: a new toolbox to study the role of IL-1 in health and disease. J Mol Med (Berl) 98, 923–930. https://doi.org/10.1007/s00109-020-01928-5
Ray-Jones, H., Duffus, K., McGovern, A., Martin, P., Shi, C., Hankinson, J., Gough, O., Yarwood, A., Morris, A.P., Adamson, A., Taylor, C., Ding, J., Gaddi, V.P., Fu, Y., Gaffney, P., Orozco, G., Warren, R.B., Eyre, S., 2020. Mapping DNA interaction landscapes in psoriasis susceptibility loci highlights KLF4 as a target gene in 9q31. BMC Biol. 18, 47. https://doi.org/10.1186/s12915-020-00779-3
Yang, J., McGovern, A., Martin, P., Duffus, K., Ge, X., Zarrineh, P., Morris, A.P., Adamson, A., Fraser, P., Rattray, M., Eyre, S., 2020. Analysis of chromatin organization and gene expression in T cells identifies functional genes for rheumatoid arthritis. Nat Commun 11, 4402. https://doi.org/10.1038/s41467-020-18180-7
Yang, N., Smyllie, N.J., Morris, H., Gonçalves, C.F., Dudek, M., Pathiranage, D.R.J., Chesham, J.E., Adamson, A., Spiller, D.G., Zindy, E., Bagnall, J., Humphreys, N., Hoyland, J., Loudon, A.S.I., Hastings, M.H., Meng, Q.-J., 2020. Quantitative live imaging of Venus::BMAL1 in a mouse model reveals complex dynamics of the master circadian clock regulator. PLoS Genet. 16, e1008729. https://doi.org/10.1371/journal.pgen.1008729
Preprints
Borland, S.J., Facchi, C., Behnsen, J., Adamson, A., Humphreys, N.E., Withers, P.J., Sherratt, M.J., Francis, S.E., Brennan, K., Ashton, N., Canfield, A.E., 2020. Loss of PKCα increases arterial medial calcification in a uremic mouse model of chronic kidney disease. bioRxiv 2020.05.20.097642. https://doi.org/10.1101/2020.05.20.097642
2019
Bageghni, S.A., Hemmings, K.E., Yuldasheva, N.Y., Maqbool, A., Gamboa-Esteves, F.O., Humphreys, N.E., Jackson, M.S., Denton, C.P., Francis, S., Porter, K.E., Ainscough, J.F., Pinteaux, E., Drinkhill, M.J., Turner, N.A., 2019. Fibroblast-specific deletion of interleukin-1 receptor-1 reduces adverse cardiac remodeling following myocardial infarction. JCI Insight 5. https://doi.org/10.1172/jci.insight.125074
Binder, P., Wang, S., Radu, M., Zin, M., Collins, L., Khan, S., Li, Y., Sekeres, K., Humphreys, N., Swanton, E., Reid, A., Pu, F., Oceandy, D., Guan, K., Hille, S.S., Frey, N., Müller, O.J., Cartwright, E.J., Chernoff, J., Wang, X., Liu, W., 2019. Pak2 as a Novel Therapeutic Target for Cardioprotective Endoplasmic Reticulum Stress Response. Circ. Res. 124, 696–711. https://doi.org/10.1161/CIRCRESAHA.118.312829
Birket, M.J., Raibaud, S., Lettieri, M., Adamson, A.D., Letang, V., Cervello, P., Redon, N., Ret, G., Viale, S., Wang, B., Biton, B., Guillemot, J.-C., Mikol, V., Leonard, J.P., Hanley, N.A., Orsini, C., Itier, J.-M., 2019. A Human Stem Cell Model of Fabry Disease Implicates LIMP-2 Accumulation in Cardiomyocyte Pathology. Stem Cell Reports 13, 380–393. https://doi.org/10.1016/j.stemcr.2019.07.004
Gurumurthy, C.B., O’Brien, A.R., Quadros, R.M., Adams, J., Alcaide, P., Ayabe, S., Ballard, J., Batra, S.K., Beauchamp, M.-C., Becker, K.A., Bernas, G., Brough, D., Carrillo-Salinas, F., Chan, W., Chen, H., Dawson, R., DeMambro, V., D’Hont, J., Dibb, K.M., Eudy, J.D., Gan, L., Gao, J., Gonzales, A., Guntur, A.R., Guo, H., Harms, D.W., Harrington, A., Hentges, K.E., Humphreys, N., Imai, S., Ishii, H., Iwama, M., Jonasch, E., Karolak, M., Keavney, B., Khin, N.-C., Konno, M., Kotani, Y., Kunihiro, Y., Lakshmanan, I., Larochelle, C., Lawrence, C.B., Li, L., Lindner, V., Liu, X.-D., Lopez-Castejon, G., Loudon, A., Lowe, J., Jerome-Majewska, L.A., Matsusaka, T., Miura, H., Miyasaka, Y., Morpurgo, B., Motyl, K., Nabeshima, Y.-I., Nakade, K., Nakashiba, T., Nakashima, K., Obata, Y., Ogiwara, S., Ouellet, M., Oxburgh, L., Piltz, S., Pinz, I., Ponnusamy, M.P., Ray, D., Redder, R.J., Rosen, C.J., Ross, N., Ruhe, M.T., Ryzhova, L., Salvador, A.M., Alam, S.S., Sedlacek, R., Sharma, K., Smith, C., Staes, K., Starrs, L., Sugiyama, F., Takahashi, S., Tanaka, T., Trafford, A.W., Uno, Y., Vanhoutte, L., Vanrockeghem, F., Willis, B.J., Wright, C.S., Yamauchi, Y., Yi, X., Yoshimi, K., Zhang, X., Zhang, Y., Ohtsuka, M., Das, S., Garry, D.J., Hochepied, T., Thomas, P., Parker-Thornburg, J., Adamson, A.D., Yoshiki, A., Schmouth, J.-F., Golovko, A., Thompson, W.R., Lloyd, K.C.K., Wood, J.A., Cowan, M., Mashimo, T., Mizuno, S., Zhu, H., Kasparek, P., Liaw, L., Miano, J.M., Burgio, G., 2019. Reproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles: a multi-center evaluation. Genome Biol. 20, 171. https://doi.org/10.1186/s13059-019-1776-2
Minshawi, F., White, M.R.H., Muller, W., Humphreys, N., Jackson, D., Campbell, B.J., Adamson, A., Papoutsopoulou, S., 2019. Human TNF-Luc reporter mouse: A new model to quantify inflammatory responses. Sci Rep 9, 193. https://doi.org/10.1038/s41598-018-36969-x
Sefton, C., Davies, A., Allen, T.-J., Wray, J.R., Shoop, R., Adamson, A., Humphreys, N., Coll, A.P., White, A., Harno, E., 2019. Metabolic Abnormalities of Chronic High-Dose Glucocorticoids Are Not Mediated by Hypothalamic AgRP in Male Mice. Endocrinology 160, 964–978. https://doi.org/10.1210/en.2019-00018
Wray, J.R., Davies, A., Sefton, C., Allen, T.-J., Adamson, A., Chapman, P., Lam, B.Y.H., Yeo, G.S.H., Coll, A.P., Harno, E., White, A., 2019. Global transcriptomic analysis of the arcuate nucleus following chronic glucocorticoid treatment. Mol Metab 26, 5–17. https://doi.org/10.1016/j.molmet.2019.05.008
Preprints
Summers, K.M., Pridans, C., Wollscheid-Lengeling, E., Grabert, K., Adamson, A., Humphreys, N.E., Irvine, K.M., Hume, D.A., 2019. Complex deletion and proximal reinsertion of a 150bp regulatory sequence in the mouse Csf1r promoter mediated by CRISPR-Cas9. bioRxiv 872200. https://doi.org/10.1101/872200
2018
Bagnall, J., Boddington, C., England, H., Brignall, R., Downton, P., Alsoufi, Z., Boyd, J., Rowe, W., Bennett, A., Walker, C., Adamson, A., Patel, N.M.X., O’Cualain, R., Schmidt, L., Spiller, D.G., Jackson, D.A., Müller, W., Muldoon, M., White, M.R.H., Paszek, P., 2018. Quantitative analysis of competitive cytokine signaling predicts tissue thresholds for the propagation of macrophage activation. Sci Signal 11. https://doi.org/10.1126/scisignal.aaf3998
Harper, C.V., Woodcock, D.J., Lam, C., Garcia-Albornoz, M., Adamson, A., Ashall, L., Rowe, W., Downton, P., Schmidt, L., West, S., Spiller, D.G., Rand, D.A., White, M.R.H., 2018. Temperature regulates NF-κB dynamics and function through timing of A20 transcription. Proc. Natl. Acad. Sci. U.S.A. 115, E5243–E5249. https://doi.org/10.1073/pnas.1803609115
Mularczyk, E.J., Singh, M., Godwin, A.R.F., Galli, F., Humphreys, N., Adamson, A.D., Mironov, A., Cain, S.A., Sengle, G., Boot-Handford, R.P., Cossu, G., Kielty, C.M., Baldock, C., 2018. ADAMTS10-mediated tissue disruption in Weill-Marchesani syndrome. Hum. Mol. Genet. 27, 3675–3687. https://doi.org/10.1093/hmg/ddy276
Roostalu, U., Aldeiri, B., Albertini, A., Humphreys, N., Simonsen-Jackson, M., Wong, J.K.F., Cossu, G., 2018. Distinct Cellular Mechanisms Underlie Smooth Muscle Turnover in Vascular Development and Repair. Circ. Res. 122, 267–281. https://doi.org/10.1161/CIRCRESAHA.117.312111
Preprints
Pickard, A., Adamson, A., Lu, Y., Chang, J., Garva, R., Hodson, N., Kadler, K.E., 2018. Collagen assembly and turnover imaged with a CRISPR-Cas9 engineered Dendra2 tag (preprint). Cell Biology. https://doi.org/10.1101/331496
2017
Daniels, M.J.D., Adamson, A.D., Humphreys, N., Brough, D., 2017. CRISPR/Cas9 mediated mutation of mouse IL-1α nuclear localisation sequence abolishes expression. Scientific Reports 7, 17077. https://doi.org/10.1038/s41598-017-17387-x
Dudek, M., Yang, N., Ruckshanthi, J.P., Williams, J., Borysiewicz, E., Wang, P., Adamson, A., Li, J., Bateman, J.F., White, M.R., Boot-Handford, R.P., Hoyland, J.A., Meng, Q.-J., 2017. The intervertebral disc contains intrinsic circadian clocks that are regulated by age and cytokines and linked to degeneration. Ann. Rheum. Dis. 76, 576–584. https://doi.org/10.1136/annrheumdis-2016-209428
2016
Adamson, A., Boddington, C., Downton, P., Rowe, W., Bagnall, J., Lam, C., Maya-Mendoza, A., Schmidt, L., Harper, C.V., Spiller, D.G., Rand, D.A., Jackson, D.A., White, M.R.H., Paszek, P., 2016. Signal transduction controls heterogeneous NF-κB dynamics and target gene expression through cytokine-specific refractory states. Nat Commun 7, 12057. https://doi.org/10.1038/ncomms12057
Ankers, J.M., Awais, R., Jones, N.A., Boyd, J., Ryan, S., Adamson, A.D., Harper, C.V., Bridge, L., Spiller, D.G., Jackson, D.A., Paszek, P., Sée, V., White, M.R., 2016. Dynamic NF-κB and E2F interactions control the priority and timing of inflammatory signalling and cell proliferation. Elife 5. https://doi.org/10.7554/eLife.10473
McNamara, A.V., Adamson, A.D., Dunham, L.S.S., Semprini, S., Spiller, D.G., McNeilly, A.S., Mullins, J.J., Davis, J.R.E., White, M.R.H., 2016. Role of Estrogen Response Element in the Human Prolactin Gene: Transcriptional Response and Timing. Mol. Endocrinol. 30, 189–200. https://doi.org/10.1210/me.2015-1186
2015
Guo, B., Yang, N., Borysiewicz, E., Dudek, M., Williams, J.L., Li, J., Maywood, E.S., Adamson, A., Hastings, M.H., Bateman, J.F., White, M.R.H., Boot-Handford, R.P., Meng, Q.J., 2015. Catabolic cytokines disrupt the circadian clock and the expression of clock-controlled genes in cartilage via an NFкB-dependent pathway. Osteoarthr. Cartil. 23, 1981–1988. https://doi.org/10.1016/j.joca.2015.02.020
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