Publications

2020

Bennett H, Aguilar-Martinez E, Adamson A. CRISPR-mediated knock-in in the mouse embryo using long single stranded DNA donors synthesised by biotinylated PCR. Methods. 2020 Oct 21

Grabert, Kathleen, Anuj Sehgal, Katharine M. Irvine, Evi Wollscheid-Lengeling, Derya D. Ozdemir, Jennifer Stables, Garry A. Luke, Martin D. Ryan,  Antony Adamson,  Neil E. Humphreys,  Cheyenne J. Sandrock,  Rocio Rojo,  Veera A. Verkasalo,  Werner Mueller,  Peter Hohenstein,  Allison R. Pettit,  Clare Pridans,  David A. Hume.  A Transgenic Line That Reports CSF1R Protein Expression Provides a Definitive Marker for the Mouse Mononuclear Phagocyte System. Journal of Immunology. 2020 Nov 2;ji2000835. https://doi.org/10.4049/jimmunol.2000835

Arwa Al Kindi, Helen Williams, Kenshiro Matsuda, Abdullah M.Alkahtani, Charis Saville, Hayley Bennett, Yasmine Al-shammari, Soo Y. Tan, Catherine O’Neill, Akane Tanaka, Hiroshi Matsuda, Peter D. Arkwright, Joanne L. Pennock. Staphylococcus aureus Second Immunoglobulin-Binding Protein drives atopic dermatitis via IL-33, 2020. Journal of Allergy and Clinical Immunology. https://doi.org/10.1016/j.jaci.2020.09.023

Hunter, A Louise ; Pelekanou, Charlotte E ; Adamson, Antony ; Downton, Polly ; Barron, Nichola J ; Cornfield, Thomas ; Poolman, Toryn M ; Humphreys, Neil ; Cunningham, Peter S ; Hodson, Leanne ; Loudon, Andrew S I ; Iqbal, Mudassar ; Bechtold, David A ; Ray, David W. Nuclear Receptor REVERBα Is a State-Dependent Regulator of Liver Energy Metabolism. Proceedings of the National Academy of Sciences, September 23, 2020. https://doi.org/10.1073/pnas.2005330117

Evans, E. L.; Povstyan, O. V.; De Vecchis, D.; Macrae, F.; Lichtenstein, L.; Futers, T. S.; Parsonage, G.; Humphreys, N. E.; Adamson, A.; Kalli, A. C.; Ludlow, M. J.; Beech, D. J. RBCs Prevent Rapid PIEZO1 Inactivation and Expose Slow Deactivation as a Mechanism of Dehydrated Hereditary Stomatocytosis. Blood 2020, 136 (1), 140–144. https://doi.org/10.1182/blood.2019004174.

Baxter, M.; Voronkov, M.; Poolman, T.; Galli, G.; Pinali, C.; Goosey, L.; Knight, A.; Krakowiak, K.; Maidstone, R.; Iqbal, M.; Zi, M.; Prehar, S.; Cartwright, E. J.; Gibbs, J.; Matthews, L. C.; Adamson, A. D.; Humphreys, N. E.; Rebelo-Guiomar, P.; Minczuk, M.; Bechtold, D. A.; Loudon, A.; Ray, D. Cardiac Mitochondrial Function Depends on BUD23 Mediated Ribosome Programming. Elife 2020, 9. https://doi.org/10.7554/eLife.50705

Yang, J.; McGovern, A.; Martin, P.; Duffus, K.; Ge, X.; Zarrineh, P.; Morris, A. P.; Adamson, A.; Fraser, P.; Rattray, M.; Eyre, S. Analysis of Chromatin Organization and Gene Expression in T Cells Identifies Functional Genes for Rheumatoid Arthritis. Nat Commun 2020, 11 (1), 4402  https://doi.org/10.1038/s41467-020-18180-7

Ray-Jones, H.; Duffus, K.; McGovern, A.; Martin, P.; Shi, C.; Hankinson, J.; Gough, O.; Yarwood, A.; Morris, A. P.; Adamson, A.; Taylor, C.; Ding, J.; Gaddi, V. P.; Fu, Y.; Gaffney, P.; Orozco, G.; Warren, R. B.; Eyre, S. Mapping DNA Interaction Landscapes in Psoriasis Susceptibility Loci Highlights KLF4 as a Target Gene in 9q31. BMC Biol. 2020, 18 (1), 47. https://doi.org/10.1186/s12915-020-00779-3

Yang, N.; Smyllie, N. J.; Morris, H.; Gonçalves, C. F.; Dudek, M.; Pathiranage, D. R. J.; Chesham, J. E.; Adamson, A.; Spiller, D. G.; Zindy, E.; Bagnall, J.; Humphreys, N.; Hoyland, J.; Loudon, A. S. I.; Hastings, M. H.; Meng, Q.-J. Quantitative Live Imaging of Venus::BMAL1 in a Mouse Model Reveals Complex Dynamics of the Master Circadian Clock Regulator. PLoS Genet. 2020, 16 (4), e1008729. https://doi.org/10.1371/journal.pgen.1008729

Chang, J.; Garva, R.; Pickard, A.; Yeung, C.-Y. C.; Mallikarjun, V.; Swift, J.; Holmes, D. F.; Calverley, B.; Lu, Y.; Adamson, A.; Raymond-Hayling, H.; Jensen, O.; Shearer, T.; Meng, Q. J.; Kadler, K. E. Circadian Control of the Secretory Pathway Maintains Collagen Homeostasis. Nat. Cell Biol. 2020, 22 (1), 74–86. https://doi.org/10.1038/s41556-019-0441-z

Pinteaux, E.; Abdulaal, W. H.; Mufazalov, I. A.; Humphreys, N. E.; Simonsen-Jackson, M.; Francis, S.; Müller, W.; Waisman, A. Cell-Specific Conditional Deletion of Interleukin-1 (IL-1) Ligands and Its Receptors: A New Toolbox to Study the Role of IL-1 in Health and Disease. J Mol Med (Berl) 2020, 98 (7), 923–930. https://doi.org/10.1007/s00109-020-01928-5. – 

2019

Summers, K. M.; Pridans, C.; Wollscheid-Lengeling, E.; Grabert, K.; Adamson, A.; Humphreys, N. E.; Irvine, K. M.; Hume, D. A. Complex Deletion and Proximal Reinsertion of a 150bp Regulatory Sequence in the Mouse Csf1r Promoter Mediated by CRISPR-Cas9. bioRxiv 2019, 872200. https://doi.org/10.1101/872200

Wray, J. R.; Davies, A.; Sefton, C.; Allen, T.-J.; Adamson, A.; Chapman, P.; Lam, B. Y. H.; Yeo, G. S. H.; Coll, A. P.; Harno, E.; White, A. Global Transcriptomic Analysis of the Arcuate Nucleus Following Chronic Glucocorticoid Treatment. Mol Metab 2019, 26, 5–17. https://doi.org/10.1016/j.molmet.2019.05.008

Gurumurthy, C. B.; O’Brien, A. R.; Quadros, R. M.; Adams, J.; Alcaide, P.; Ayabe, S.; Ballard, J.; Batra, S. K.; Beauchamp, M.-C.; Becker, K. A.; Bernas, G.; Brough, D.; Carrillo-Salinas, F.; Chan, W.; Chen, H.; Dawson, R.; DeMambro, V.; D’Hont, J.; Dibb, K. M.; Eudy, J. D.; Gan, L.; Gao, J.; Gonzales, A.; Guntur, A. R.; Guo, H.; Harms, D. W.; Harrington, A.; Hentges, K. E.; Humphreys, N.; Imai, S.; Ishii, H.; Iwama, M.; Jonasch, E.; Karolak, M.; Keavney, B.; Khin, N.-C.; Konno, M.; Kotani, Y.; Kunihiro, Y.; Lakshmanan, I.; Larochelle, C.; Lawrence, C. B.; Li, L.; Lindner, V.; Liu, X.-D.; Lopez-Castejon, G.; Loudon, A.; Lowe, J.; Jerome-Majewska, L. A.; Matsusaka, T.; Miura, H.; Miyasaka, Y.; Morpurgo, B.; Motyl, K.; Nabeshima, Y.-I.; Nakade, K.; Nakashiba, T.; Nakashima, K.; Obata, Y.; Ogiwara, S.; Ouellet, M.; Oxburgh, L.; Piltz, S.; Pinz, I.; Ponnusamy, M. P.; Ray, D.; Redder, R. J.; Rosen, C. J.; Ross, N.; Ruhe, M. T.; Ryzhova, L.; Salvador, A. M.; Alam, S. S.; Sedlacek, R.; Sharma, K.; Smith, C.; Staes, K.; Starrs, L.; Sugiyama, F.; Takahashi, S.; Tanaka, T.; Trafford, A. W.; Uno, Y.; Vanhoutte, L.; Vanrockeghem, F.; Willis, B. J.; Wright, C. S.; Yamauchi, Y.; Yi, X.; Yoshimi, K.; Zhang, X.; Zhang, Y.; Ohtsuka, M.; Das, S.; Garry, D. J.; Hochepied, T.; Thomas, P.; Parker-Thornburg, J.; Adamson, A. D.; Yoshiki, A.; Schmouth, J.-F.; Golovko, A.; Thompson, W. R.; Lloyd, K. C. K.; Wood, J. A.; Cowan, M.; Mashimo, T.; Mizuno, S.; Zhu, H.; Kasparek, P.; Liaw, L.; Miano, J. M.; Burgio, G. Reproducibility of CRISPR-Cas9 Methods for Generation of Conditional Mouse Alleles: A Multi-Center Evaluation. Genome Biol. 2019, 20 (1), 171. https://doi.org/10.1186/s13059-019-1776-2

Birket, M. J.; Raibaud, S.; Lettieri, M.; Adamson, A. D.; Letang, V.; Cervello, P.; Redon, N.; Ret, G.; Viale, S.; Wang, B.; Biton, B.; Guillemot, J.-C.; Mikol, V.; Leonard, J. P.; Hanley, N. A.; Orsini, C.; Itier, J.-M. A Human Stem Cell Model of Fabry Disease Implicates LIMP-2 Accumulation in Cardiomyocyte Pathology. Stem Cell Reports 2019, 13 (2), 380–393. https://doi.org/10.1016/j.stemcr.2019.07.004

Bageghni, S. A.; Hemmings, K. E.; Yuldasheva, N. Y.; Maqbool, A.; Gamboa-Esteves, F. O.; Humphreys, N. E.; Jackson, M. S.; Denton, C. P.; Francis, S.; Porter, K. E.; Ainscough, J. F.; Pinteaux, E.; Drinkhill, M. J.; Turner, N. A. Fibroblast-Specific Deletion of Interleukin-1 Receptor-1 Reduces Adverse Cardiac Remodeling Following Myocardial Infarction. JCI Insight 2019, 5. https://doi.org/10.1172/jci.insight.125074

Sefton, C.; Davies, A.; Allen, T.-J.; Wray, J. R.; Shoop, R.; Adamson, A.; Humphreys, N.; Coll, A. P.; White, A.; Harno, E. Metabolic Abnormalities of Chronic High-Dose Glucocorticoids Are Not Mediated by Hypothalamic AgRP in Male Mice. Endocrinology 2019, 160 (5), 964–978. https://doi.org/10.1210/en.2019-00018

Binder, P.; Wang, S.; Radu, M.; Zin, M.; Collins, L.; Khan, S.; Li, Y.; Sekeres, K.; Humphreys, N.; Swanton, E.; Reid, A.; Pu, F.; Oceandy, D.; Guan, K.; Hille, S. S.; Frey, N.; Müller, O. J.; Cartwright, E. J.; Chernoff, J.; Wang, X.; Liu, W. Pak2 as a Novel Therapeutic Target for Cardioprotective Endoplasmic Reticulum Stress Response. Circ. Res. 2019, 124 (5), 696–711. https://doi.org/10.1161/CIRCRESAHA.118.312829.

Minshawi, F.; White, M. R. H.; Muller, W.; Humphreys, N.; Jackson, D.; Campbell, B. J.; Adamson, A*; Papoutsopoulou, S*. Human TNF-Luc Reporter Mouse: A New Model to Quantify Inflammatory Responses. Sci Rep 2019, 9 (1), 193. https://doi.org/10.1038/s41598-018-36969-x. *Joint corresponding author

 

2018

Pickard, A.; Adamson, A.; Lu, Y.; Chang, J.; Garva, R.; Hodson, N.; Kadler, K. E. Collagen Assembly and Turnover Imaged with a CRISPR-Cas9 Engineered Dendra2 Tag; BioRxiv, 2018. https://doi.org/10.1101/331496

Mularczyk, E. J.; Singh, M.; Godwin, A. R. F.; Galli, F.; Humphreys, N.; Adamson, A. D.; Mironov, A.; Cain, S. A.; Sengle, G.; Boot-Handford, R. P.; Cossu, G.; Kielty, C. M.; Baldock, C. ADAMTS10-Mediated Tissue Disruption in Weill-Marchesani Syndrome. Hum. Mol. Genet. 2018, 27 (21), 3675–3687. https://doi.org/10.1093/hmg/ddy276

Bagnall, J.; Boddington, C.; England, H.; Brignall, R.; Downton, P.; Alsoufi, Z.; Boyd, J.; Rowe, W.; Bennett, A.; Walker, C.; Adamson, A.; Patel, N. M. X.; O’Cualain, R.; Schmidt, L.; Spiller, D. G.; Jackson, D. A.; Müller, W.; Muldoon, M.; White, M. R. H.; Paszek, P. Quantitative Analysis of Competitive Cytokine Signaling Predicts Tissue Thresholds for the Propagation of Macrophage Activation. Sci Signal 2018, 11 (540). https://doi.org/10.1126/scisignal.aaf3998

Harper, C. V.; Woodcock, D. J.; Lam, C.; Garcia-Albornoz, M.; Adamson, A.; Ashall, L.; Rowe, W.; Downton, P.; Schmidt, L.; West, S.; Spiller, D. G.; Rand, D. A.; White, M. R. H. Temperature Regulates NF-ΚB Dynamics and Function through Timing of A20 Transcription. Proc. Natl. Acad. Sci. U.S.A. 2018, 115 (22), E5243–E5249. https://doi.org/10.1073/pnas.1803609115

Roostalu, U.; Aldeiri, B.; Albertini, A.; Humphreys, N.; Simonsen-Jackson, M.; Wong, J. K. F.; Cossu, G. Distinct Cellular Mechanisms Underlie Smooth Muscle Turnover in Vascular Development and Repair. Circ. Res. 2018, 122 (2), 267–281. https://doi.org/10.1161/CIRCRESAHA.117.312111.

 

2017

Daniels, M. J. D.; Adamson, A. D.; Humphreys, N.; Brough, D. CRISPR/Cas9 Mediated Mutation of Mouse IL-1α Nuclear Localisation Sequence Abolishes Expression. Scientific Reports 2017, 7 (1), 17077. https://doi.org/10.1038/s41598-017-17387-x.

Richardson, R.; Mitchell, K.; Hammond, N. L.; Mollo, M. R.; Kouwenhoven, E. N.; Wyatt, N. D.; Donaldson, I. J.; Zeef, L.; Burgis, T.; Blance, R.; van Heeringen, S. J.; Stunnenberg, H. G.; Zhou, H.; Missero, C.; Romano, R. A.; Sinha, S.; Dixon, M. J.; Dixon, J. P63 Exerts Spatio-Temporal Control of Palatal Epithelial Cell Fate to Prevent Cleft Palate. PLoS Genet. 2017, 13 (6), e1006828. https://doi.org/10.1371/journal.pgen.1006828

Dudek, M.; Yang, N.; Ruckshanthi, J. P.; Williams, J.; Borysiewicz, E.; Wang, P.; Adamson, A.; Li, J.; Bateman, J. F.; White, M. R.; Boot-Handford, R. P.; Hoyland, J. A.; Meng, Q.-J. The Intervertebral Disc Contains Intrinsic Circadian Clocks That Are Regulated by Age and Cytokines and Linked to Degeneration. Ann. Rheum. Dis. 2017, 76 (3), 576–584. https://doi.org/10.1136/annrheumdis-2016-209428

 

2016

McNamara, A. V.; Adamson, A. D.; Dunham, L. S. S.; Semprini, S.; Spiller, D. G.; McNeilly, A. S.; Mullins, J. J.; Davis, J. R. E.; White, M. R. H. Role of Estrogen Response Element in the Human Prolactin Gene: Transcriptional Response and Timing. Mol. Endocrinol. 2016, 30 (2), 189–200. https://doi.org/10.1210/me.2015-1186

Adamson, A.; Boddington, C.; Downton, P.; Rowe, W.; Bagnall, J.; Lam, C.; Maya-Mendoza, A.; Schmidt, L.; Harper, C. V.; Spiller, D. G.; Rand, D. A.; Jackson, D. A.; White, M. R. H.; Paszek, P. Signal Transduction Controls Heterogeneous NF-ΚB Dynamics and Target Gene Expression through Cytokine-Specific Refractory States. Nat Commun 2016, 7, 12057. https://doi.org/10.1038/ncomms12057

Ankers, J. M.; Awais, R.; Jones, N. A.; Boyd, J.; Ryan, S.; Adamson, A. D.; Harper, C. V.; Bridge, L.; Spiller, D. G.; Jackson, D. A.; Paszek, P.; Sée, V.; White, M. R. Dynamic NF-ΚB and E2F Interactions Control the Priority and Timing of Inflammatory Signalling and Cell Proliferation. Elife 2016, 5. https://doi.org/10.7554/eLife.10473.

 

2015

Guo, B.; Yang, N.; Borysiewicz, E.; Dudek, M.; Williams, J. L.; Li, J.; Maywood, E. S.; Adamson, A.; Hastings, M. H.; Bateman, J. F.; White, M. R. H.; Boot-Handford, R. P.; Meng, Q. J. Catabolic Cytokines Disrupt the Circadian Clock and the Expression of Clock-Controlled Genes in Cartilage via an NFкB-Dependent Pathway. Osteoarthr. Cartil. 2015, 23 (11), 1981–1988. https://doi.org/10.1016/j.joca.2015.02.020

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