Introduction For many years proteomics type mass spec experiments were all acquired using the same basic approach, Data Directed Analysis (DDA), but now a new acquisition methodology is becoming more popular Data Independant Analysis (DIA). In this post I’ll describe...
Investigating protein purity is a tricky though valuable question. The reason why it is tricky is that there are many different ways at looking at a biological sample to see what may have gone wrong e.g... Have my proteins been post-translationally modified (e.g....
IntroductionMatch-UP posts compares mass spec systems in the BioMS facility to give you an idea of how they compare. They are fact based but there will also be chunks of opinion and experience as well so these comparisons should be considered the beginnings of...
Active fromFebruary 2020Introduction:The BioMS Facility is there to help you obtain the best possible data in a timely fashion. To do this the facility needs to have all the relevant information to ensure the correct analyses are performed and to know where your...
When comparing sample preparation methods you need to consider what success looks like. BioMS's goals for sample prep methods are as follows: Ease of use: The method must be comparatively easy to follow as this means it is more likely to be used and less likely to go...
This post follows on from a conversation with Christoph Borchers of the University of Vancouver in which he states “Accuracy is not important, precision is everything”. This is a highly provocative statement, especially in the analytical world but is he right?To begin...
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